21,683 research outputs found
A comparison study on algorithms of detecting long forms for short forms in biomedical text
<p>Abstract</p> <p>Motivation</p> <p>With more and more research dedicated to literature mining in the biomedical domain, more and more systems are available for people to choose from when building literature mining applications. In this study, we focus on one specific kind of literature mining task, i.e., detecting definitions of acronyms, abbreviations, and symbols in biomedical text. We denote acronyms, abbreviations, and symbols as short forms (SFs) and their corresponding definitions as long forms (LFs). The study was designed to answer the following questions; i) how well a system performs in detecting LFs from novel text, ii) what the coverage is for various terminological knowledge bases in including SFs as synonyms of their LFs, and iii) how to combine results from various SF knowledge bases.</p> <p>Method</p> <p>We evaluated the following three publicly available detection systems in detecting LFs for SFs: i) a handcrafted pattern/rule based system by Ao and Takagi, ALICE, ii) a machine learning system by Chang et al., and iii) a simple alignment-based program by Schwartz and Hearst. In addition, we investigated the conceptual coverage of two terminological knowledge bases: i) the UMLS (the Unified Medical Language System), and ii) the BioThesaurus (a thesaurus of names for all UniProt protein records). We also implemented a web interface that provides a virtual integration of various SF knowledge bases.</p> <p>Results</p> <p>We found that detection systems agree with each other on most cases, and the existing terminological knowledge bases have a good coverage of synonymous relationship for frequently defined LFs. The web interface allows people to detect SF definitions from text and to search several SF knowledge bases.</p> <p>Availability</p> <p>The web site is <url>http://gauss.dbb.georgetown.edu/liblab/SFThesaurus</url>.</p
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BADREX: In situ expansion and coreference of biomedical abbreviations using dynamic regular expressions
BADREX uses dynamically generated regular expressions to annotate term definitionâterm abbreviation pairs, and corefers unpaired acronyms and abbreviations back to their initial definition in the text. Against the Medstract corpus BADREX achieves precision and recall of 98% and 97%, and against a much larger corpus, 90% and 85%, respectively. BADREX yields improved performance over previous approaches, requires no training data and allows runtime customisation of its input parameters. BADREX is freely available from https://github.com/philgooch/BADREX-Biomedical-Abbreviation- Expander as a plugin for the General Architecture for Text Engineering (GATE) framework and is licensed under the GPLv3
Towards cross-lingual alerting for bursty epidemic events
Background: Online news reports are increasingly becoming a source for event
based early warning systems that detect natural disasters. Harnessing the
massive volume of information available from multilingual newswire presents as
many challenges as opportunities due to the patterns of reporting complex
spatiotemporal events. Results: In this article we study the problem of
utilising correlated event reports across languages. We track the evolution of
16 disease outbreaks using 5 temporal aberration detection algorithms on
text-mined events classified according to disease and outbreak country. Using
ProMED reports as a silver standard, comparative analysis of news data for 13
languages over a 129 day trial period showed improved sensitivity, F1 and
timeliness across most models using cross-lingual events. We report a detailed
case study analysis for Cholera in Angola 2010 which highlights the challenges
faced in correlating news events with the silver standard. Conclusions: The
results show that automated health surveillance using multilingual text mining
has the potential to turn low value news into high value alerts if informed
choices are used to govern the selection of models and data sources. An
implementation of the C2 alerting algorithm using multilingual news is
available at the BioCaster portal http://born.nii.ac.jp/?page=globalroundup
What's unusual in online disease outbreak news?
Background: Accurate and timely detection of public health events of
international concern is necessary to help support risk assessment and response
and save lives. Novel event-based methods that use the World Wide Web as a
signal source offer potential to extend health surveillance into areas where
traditional indicator networks are lacking. In this paper we address the issue
of systematically evaluating online health news to support automatic alerting
using daily disease-country counts text mined from real world data using
BioCaster. For 18 data sets produced by BioCaster, we compare 5 aberration
detection algorithms (EARS C2, C3, W2, F-statistic and EWMA) for performance
against expert moderated ProMED-mail postings. Results: We report sensitivity,
specificity, positive predictive value (PPV), negative predictive value (NPV),
mean alerts/100 days and F1, at 95% confidence interval (CI) for 287
ProMED-mail postings on 18 outbreaks across 14 countries over a 366 day period.
Results indicate that W2 had the best F1 with a slight benefit for day of week
effect over C2. In drill down analysis we indicate issues arising from the
granular choice of country-level modeling, sudden drops in reporting due to day
of week effects and reporting bias. Automatic alerting has been implemented in
BioCaster available from http://born.nii.ac.jp. Conclusions: Online health news
alerts have the potential to enhance manual analytical methods by increasing
throughput, timeliness and detection rates. Systematic evaluation of health
news aberrations is necessary to push forward our understanding of the complex
relationship between news report volumes and case numbers and to select the
best performing features and algorithms
Chi-square-based scoring function for categorization of MEDLINE citations
Objectives: Text categorization has been used in biomedical informatics for
identifying documents containing relevant topics of interest. We developed a
simple method that uses a chi-square-based scoring function to determine the
likelihood of MEDLINE citations containing genetic relevant topic. Methods: Our
procedure requires construction of a genetic and a nongenetic domain document
corpus. We used MeSH descriptors assigned to MEDLINE citations for this
categorization task. We compared frequencies of MeSH descriptors between two
corpora applying chi-square test. A MeSH descriptor was considered to be a
positive indicator if its relative observed frequency in the genetic domain
corpus was greater than its relative observed frequency in the nongenetic
domain corpus. The output of the proposed method is a list of scores for all
the citations, with the highest score given to those citations containing MeSH
descriptors typical for the genetic domain. Results: Validation was done on a
set of 734 manually annotated MEDLINE citations. It achieved predictive
accuracy of 0.87 with 0.69 recall and 0.64 precision. We evaluated the method
by comparing it to three machine learning algorithms (support vector machines,
decision trees, na\"ive Bayes). Although the differences were not statistically
significantly different, results showed that our chi-square scoring performs as
good as compared machine learning algorithms. Conclusions: We suggest that the
chi-square scoring is an effective solution to help categorize MEDLINE
citations. The algorithm is implemented in the BITOLA literature-based
discovery support system as a preprocessor for gene symbol disambiguation
process.Comment: 34 pages, 2 figure
BIOADI: a machine learning approach to identifying abbreviations and definitions in biological literature
BACKGROUND: To automatically process large quantities of biological literature for knowledge discovery and information curation, text mining tools are becoming essential. Abbreviation recognition is related to NER and can be considered as a pair recognition task of a terminology and its corresponding abbreviation from free text. The successful identification of abbreviation and its corresponding definition is not only a prerequisite to index terms of text databases to produce articles of related interests, but also a building block to improve existing gene mention tagging and gene normalization tools. RESULTS: Our approach to abbreviation recognition (AR) is based on machine-learning, which exploits a novel set of rich features to learn rules from training data. Tested on the AB3P corpus, our system demonstrated a F-score of 89.90% with 95.86% precision at 84.64% recall, higher than the result achieved by the existing best AR performance system. We also annotated a new corpus of 1200 PubMed abstracts which was derived from BioCreative II gene normalization corpus. On our annotated corpus, our system achieved a F-score of 86.20% with 93.52% precision at 79.95% recall, which also outperforms all tested systems. CONCLUSION: By applying our system to extract all short form-long form pairs from all available PubMed abstracts, we have constructed BIOADI. Mining BIOADI reveals many interesting trends of bio-medical research. Besides, we also provide an off-line AR software in the download section on http://bioagent.iis.sinica.edu.tw/BIOADI/
A Survey on Deep Learning in Medical Image Analysis
Deep learning algorithms, in particular convolutional networks, have rapidly
become a methodology of choice for analyzing medical images. This paper reviews
the major deep learning concepts pertinent to medical image analysis and
summarizes over 300 contributions to the field, most of which appeared in the
last year. We survey the use of deep learning for image classification, object
detection, segmentation, registration, and other tasks and provide concise
overviews of studies per application area. Open challenges and directions for
future research are discussed.Comment: Revised survey includes expanded discussion section and reworked
introductory section on common deep architectures. Added missed papers from
before Feb 1st 201
The biomedical abbreviation recognition and resolution (BARR) track: Benchmarking, evaluation and importance of abbreviation recognition systems applied to Spanish biomedical abstracts
Healthcare professionals are generating a substantial volume of clinical data in narrative form. As healthcare providers are confronted with serious time constraints, they frequently use telegraphic phrases, domain-specific abbreviations and shorthand notes. Efficient clinical text processing tools need to cope with the recognition and resolution of abbreviations, a task that has been extensively studied for English documents. Despite the outstanding number of clinical documents written worldwide in Spanish, only a marginal amount of studies has been published on this subject. In clinical texts, as opposed to the medical literature, abbreviations are generally used without their definitions or expanded forms. The aim of the first Biomedical Abbreviation Recognition and Resolution (BARR) track, posed at the IberEval 2017 evaluation campaign, was to assess and promote the development of systems for generating a sense inventory of medical abbreviations. The BARR track required the detection of mentions of abbreviations or short forms and their corresponding long forms or definitions from Spanish medical abstracts. For this track, the organizers provided the BARR medical document collection, the BARR corpus of manually annotated abstracts labelled by domain experts and the BARR-Markyt evaluation platform. A total of 7 teams submitted 25 runs for the two BARR subtasks: (a) the identification of mentions of abbreviations and their definitions and (b) the correct detection of short form-long form pairs. Here we describe the BARR track setting, the obtained results and the methodologies used by participating systems. The BARR task summary, corpus, resources and evaluation tool for testing systems beyond this campaign are available at: http://temu.inab.org
.We acknowledge the Encomienda MINETAD-CNIO/OTG Sanidad Plan TL and Open-Minted (654021) H2020 project for funding.Postprint (published version
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