3D statistical shape analysis of the face in Apert syndrome

Timely diagnosis of craniofacial syndromes as well as adequate timing and choice of surgical technique are essential for proper care management. Statistical shape models and machine learning approaches are playing an increasing role in Medicine and have proven its usefulness. Frameworks that automate processes have become more popular. The use of 2D photographs for automated syndromic identification has shown its potential with the Face2Gene application. Yet, using 3D shape information without texture has not been studied in such depth. Moreover, the use of these models to understand shape change during growth and its applicability for surgical outcome measurements have not been analysed at length. This thesis presents a framework using state-of-the-art machine learning and computer vision algorithms to explore possibilities for automated syndrome identification based on shape information only. The purpose of this was to enhance understanding of the natural development of the Apert syndromic face and its abnormality as compared to a normative group. An additional method was used to objectify changes as result of facial bipartition distraction, a common surgical correction technique, providing information on the successfulness and on inadequacies in terms of facial normalisation. Growth curves were constructed to further quantify facial abnormalities in Apert syndrome over time along with 3D shape models for intuitive visualisation of the shape variations. Post-operative models were built and compared with age-matched normative data to understand where normalisation is coming short. The findings in this thesis provide markers for future translational research and may accelerate the adoption of the next generation diagnostics and surgical planning tools to further supplement the clinical decision-making process and ultimately to improve patients’ quality of life

Feature Extraction Methods for Character Recognition

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To Draw or Not to Draw: Recognizing Stroke-Hover Intent in Gesture-Free Bare-Hand Mid-Air Drawing Tasks

Over the past several decades, technological advancements have introduced new modes of communication with the computers, introducing a shift from traditional mouse and keyboard interfaces. While touch based interactions are abundantly being used today, latest developments in computer vision, body tracking stereo cameras, and augmented and virtual reality have now enabled communicating with the computers using spatial input in the physical 3D space. These techniques are now being integrated into several design critical tasks like sketching, modeling, etc. through sophisticated methodologies and use of specialized instrumented devices. One of the prime challenges in design research is to make this spatial interaction with the computer as intuitive as possible for the users. Drawing curves in mid-air with fingers, is a fundamental task with applications to 3D sketching, geometric modeling, handwriting recognition, and authentication. Sketching in general, is a crucial mode for effective idea communication between designers. Mid-air curve input is typically accomplished through instrumented controllers, specific hand postures, or pre-defined hand gestures, in presence of depth and motion sensing cameras. The user may use any of these modalities to express the intention to start or stop sketching. However, apart from suffering with issues like lack of robustness, the use of such gestures, specific postures, or the necessity of instrumented controllers for design specific tasks further result in an additional cognitive load on the user. To address the problems associated with different mid-air curve input modalities, the presented research discusses the design, development, and evaluation of data driven models for intent recognition in non-instrumented, gesture-free, bare-hand mid-air drawing tasks. The research is motivated by a behavioral study that demonstrates the need for such an approach due to the lack of robustness and intuitiveness while using hand postures and instrumented devices. The main objective is to study how users move during mid-air sketching, develop qualitative insights regarding such movements, and consequently implement a computational approach to determine when the user intends to draw in mid-air without the use of an explicit mechanism (such as an instrumented controller or a specified hand-posture). By recording the user’s hand trajectory, the idea is to simply classify this point as either hover or stroke. The resulting model allows for the classification of points on the user’s spatial trajectory. Drawing inspiration from the way users sketch in mid-air, this research first specifies the necessity for an alternate approach for processing bare hand mid-air curves in a continuous fashion. Further, this research presents a novel drawing intent recognition work flow for every recorded drawing point, using three different approaches. We begin with recording mid-air drawing data and developing a classification model based on the extracted geometric properties of the recorded data. The main goal behind developing this model is to identify drawing intent from critical geometric and temporal features. In the second approach, we explore the variations in prediction quality of the model by improving the dimensionality of data used as mid-air curve input. Finally, in the third approach, we seek to understand the drawing intention from mid-air curves using sophisticated dimensionality reduction neural networks such as autoencoders. Finally, the broad level implications of this research are discussed, with potential development areas in the design and research of mid-air interactions

Fused mechanomyography and inertial measurement for human-robot interface

Human-Machine Interfaces (HMI) are the technology through which we interact with the ever-increasing quantity of smart devices surrounding us. The fundamental goal of an HMI is to facilitate robot control through uniting a human operator as the supervisor with a machine as the task executor. Sensors, actuators, and onboard intelligence have not reached the point where robotic manipulators may function with complete autonomy and therefore some form of HMI is still necessary in unstructured environments. These may include environments where direct human action is undesirable or infeasible, and situations where a robot must assist and/or interface with people. Contemporary literature has introduced concepts such as body-worn mechanical devices, instrumented gloves, inertial or electromagnetic motion tracking sensors on the arms, head, or legs, electroencephalographic (EEG) brain activity sensors, electromyographic (EMG) muscular activity sensors and camera-based (vision) interfaces to recognize hand gestures and/or track arm motions for assessment of operator intent and generation of robotic control signals. While these developments offer a wealth of future potential their utility has been largely restricted to laboratory demonstrations in controlled environments due to issues such as lack of portability and robustness and an inability to extract operator intent for both arm and hand motion. Wearable physiological sensors hold particular promise for capture of human intent/command. EMG-based gesture recognition systems in particular have received significant attention in recent literature. As wearable pervasive devices, they offer benefits over camera or physical input systems in that they neither inhibit the user physically nor constrain the user to a location where the sensors are deployed. Despite these benefits, EMG alone has yet to demonstrate the capacity to recognize both gross movement (e.g. arm motion) and finer grasping (e.g. hand movement). As such, many researchers have proposed fusing muscle activity (EMG) and motion tracking e.g. (inertial measurement) to combine arm motion and grasp intent as HMI input for manipulator control. However, such work has arguably reached a plateau since EMG suffers from interference from environmental factors which cause signal degradation over time, demands an electrical connection with the skin, and has not demonstrated the capacity to function out of controlled environments for long periods of time. This thesis proposes a new form of gesture-based interface utilising a novel combination of inertial measurement units (IMUs) and mechanomyography sensors (MMGs). The modular system permits numerous configurations of IMU to derive body kinematics in real-time and uses this to convert arm movements into control signals. Additionally, bands containing six mechanomyography sensors were used to observe muscular contractions in the forearm which are generated using specific hand motions. This combination of continuous and discrete control signals allows a large variety of smart devices to be controlled. Several methods of pattern recognition were implemented to provide accurate decoding of the mechanomyographic information, including Linear Discriminant Analysis and Support Vector Machines. Based on these techniques, accuracies of 94.5% and 94.6% respectively were achieved for 12 gesture classification. In real-time tests, accuracies of 95.6% were achieved in 5 gesture classification. It has previously been noted that MMG sensors are susceptible to motion induced interference. The thesis also established that arm pose also changes the measured signal. This thesis introduces a new method of fusing of IMU and MMG to provide a classification that is robust to both of these sources of interference. Additionally, an improvement in orientation estimation, and a new orientation estimation algorithm are proposed. These improvements to the robustness of the system provide the first solution that is able to reliably track both motion and muscle activity for extended periods of time for HMI outside a clinical environment. Application in robot teleoperation in both real-world and virtual environments were explored. With multiple degrees of freedom, robot teleoperation provides an ideal test platform for HMI devices, since it requires a combination of continuous and discrete control signals. The field of prosthetics also represents a unique challenge for HMI applications. In an ideal situation, the sensor suite should be capable of detecting the muscular activity in the residual limb which is naturally indicative of intent to perform a specific hand pose and trigger this post in the prosthetic device. Dynamic environmental conditions within a socket such as skin impedance have delayed the translation of gesture control systems into prosthetic devices, however mechanomyography sensors are unaffected by such issues. There is huge potential for a system like this to be utilised as a controller as ubiquitous computing systems become more prevalent, and as the desire for a simple, universal interface increases. Such systems have the potential to impact significantly on the quality of life of prosthetic users and others.Open Acces