Efficient fetal-maternal ECG signal separation from two channel maternal abdominal ECG via diffusion-based channel selection

There is a need for affordable, widely deployable maternal-fetal ECG monitors to improve maternal and fetal health during pregnancy and delivery. Based on the diffusion-based channel selection, here we present the mathematical formalism and clinical validation of an algorithm capable of accurate separation of maternal and fetal ECG from a two channel signal acquired over maternal abdomen

Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components

This study presents a systematic comparison of different approaches to the automated selection of the principal components (PC) which optimise the detection of maternal and fetal heart beats from non-invasive maternal abdominal recordings. A public database of 75 4-channel non-invasive maternal abdominal recordings was used for training the algorithm. Four methods were developed and assessed to determine the optimal PC: (1) power spectral distribution, (2) root mean square, (3) sample entropy, and (4) QRS template. The sensitivity of the performance of the algorithm to large-amplitude noise removal (by wavelet de-noising) and maternal beat cancellation methods were also assessed. The accuracy of maternal and fetal beat detection was assessed against reference annotations and quantified using the detection accuracy score F1 [2*PPV*Se / (PPV + Se)], sensitivity (Se), and positive predictive value (PPV). The best performing implementation was assessed on a test dataset of 100 recordings and the agreement between the computed and the reference fetal heart rate (fHR) and fetal RR (fRR) time series quantified. The best performance for detecting maternal beats (F1 99.3%, Se 99.0%, PPV 99.7%) was obtained when using the QRS template method to select the optimal maternal PC and applying wavelet de-noising. The best performance for detecting fetal beats (F1 89.8%, Se 89.3%, PPV 90.5%) was obtained when the optimal fetal PC was selected using the sample entropy method and utilising a fixed-length time window for the cancellation of the maternal beats. The performance on the test dataset was 142.7 beats2/min2 for fHR and 19.9 ms for fRR, ranking respectively 14 and 17 (out of 29) when compared to the other algorithms presented at the Physionet Challenge 2013

Algorithms for information extraction and signal annotation on long-term biosignals using clustering techniques

Dissertação para obtenção do Grau de Mestre em Engenharia BiomédicaOne of the biggest challenges when analysing data is to extract information from it, especially if we dealing with very large sized data, which brings a new set of barriers to be overcome. The extracted information can be used to aid physicians in their diagnosis since biosignals often carry vital information on the subjects. In this research work, we present a signal-independent algorithm with two main goals: perform events detection in biosignals and, with those events, extract information using a set of distance measures which will be used as input to a parallel version of the k-means clustering algorithm. The first goal is achieved by using two different approaches. Events can be found based on peaks detection through an adaptive threshold defined as the signal’s root mean square (RMS) or by morphological analysis through the computation of the signal’s meanwave. The final goal is achieved by dividing the distance measures into n parts and by performing k-means individually. In order to improve speed performance, parallel computing techniques were applied. For this study, a set of different types of signals was acquired and annotated by our algorithm. By visual inspection, the L1 and L2 Minkowski distances returned an output that allowed clustering signals’ cycles with an efficiency of 97:5% and 97:3%, respectively. Using the meanwave distance, our algorithm achieved an accuracy of 97:4%. For the downloaded ECGs from the Physionet databases, the developed algorithm detected 638 out of 644 manually annotated events provided by physicians. The fact that this algorithm can be applied to long-term raw biosignals and without requiring any prior information about them makes it an important contribution in biosignals’ information extraction and annotation