Automatic Heart Sounds Segmentation based on the Correlation Coefficients Matrix for Similar Cardiac Cycles Identification

This paper proposes a novel automatic heart sounds segmentation method for deployment in heart valve defect diagnosis. The method is based on the correlation coefficients matrix, calculated between all the heart cycles for similarity identification. Firstly, fundamental heart sounds (S1 and S2) in the presence of extra gallop sounds such as S3 and/or S4 and murmurs are localized with more accuracy. Secondly, two similarity-based filtering approaches (using time and time-frequency domains, respectively) for correlated heart cycles identification are proposed and evaluated in the context of professional clinical auscultated heart sounds of adult patients. Results show the superiority of the novel time-frequency method proposed here particularly in the presence of extra gallop sounds

Prediction of Cardiovascular Diseases by Integrating Electrocardiogram (ECG) and Phonocardiogram (PCG) Multi-Modal Features using Hidden Semi Morkov Model

Because the health care field generates a large amount of data, we must employ modern ways to handle this data in order to give effective outcomes and make successful decisions based on data. Heart diseases are the major cause of mortality worldwide, accounting for 1/3th of all fatalities. Cardiovascular disease detection can be accomplished by the detection of disturbance in cardiac signals, one of which is known as phonocardiography. The aim of this project is for using machine learning to categorize cardiac illness based on electrocardiogram (ECG) and phonocardiogram (PCG) readings. The investigation began with signal preprocessing, which included cutting and normalizing the signal, and was accompanied by a continuous wavelet transformation utilizing a mother wavelet analytic morlet. The results of the decomposition are shown using a scalogram, and the outcomes are predicted using the Hidden semi morkov model (HSMM). In the first phase, we submit the dataset file and choose an algorithm to run on the chosen dataset. The accuracy of each selected method is then predicted, along with a graph, and a modal is built for the one with the max frequency by training the dataset to it. In the following step, input for each cardiac parameter is provided, and the sick stage of the heart is predicted based on the modal created. We then take measures based on the patient's condition. When compared to current approaches, the suggested HSMM has 0.952 sensitivity, 0.92 specificity, 0.94 F-score, 0.91 ACC, and 0.96 AUC

Automatic analysis and classification of cardiac acoustic signals for long term monitoring

Objective: Cardiovascular diseases are the leading cause of death worldwide resulting in over 17.9 million deaths each year. Most of these diseases are preventable and treatable, but their progression and outcomes are significantly more positive with early-stage diagnosis and proper disease management. Among the approaches available to assist with the task of early-stage diagnosis and management of cardiac conditions, automatic analysis of auscultatory recordings is one of the most promising ones, since it could be particularly suitable for ambulatory/wearable monitoring. Thus, proper investigation of abnormalities present in cardiac acoustic signals can provide vital clinical information to assist long term monitoring. Cardiac acoustic signals, however, are very susceptible to noise and artifacts, and their characteristics vary largely with the recording conditions which makes the analysis challenging. Additionally, there are challenges in the steps used for automatic analysis and classification of cardiac acoustic signals. Broadly, these steps are the segmentation, feature extraction and subsequent classification of recorded signals using selected features. This thesis presents approaches using novel features with the aim to assist the automatic early-stage detection of cardiovascular diseases with improved performance, using cardiac acoustic signals collected in real-world conditions. Methods: Cardiac auscultatory recordings were studied to identify potential features to help in the classification of recordings from subjects with and without cardiac diseases. The diseases considered in this study for the identification of the symptoms and characteristics are the valvular heart diseases due to stenosis and regurgitation, atrial fibrillation, and splitting of fundamental heart sounds leading to additional lub/dub sounds in the systole or diastole interval of a cardiac cycle. The localisation of cardiac sounds of interest was performed using an adaptive wavelet-based filtering in combination with the Shannon energy envelope and prior information of fundamental heart sounds. This is a prerequisite step for the feature extraction and subsequent classification of recordings, leading to a more precise diagnosis. Localised segments of S1 and S2 sounds, and artifacts, were used to extract a set of perceptual and statistical features using wavelet transform, homomorphic filtering, Hilbert transform and mel-scale filtering, which were then fed to train an ensemble classifier to interpret S1 and S2 sounds. Once sound peaks of interest were identified, features extracted from these peaks, together with the features used for the identification of S1 and S2 sounds, were used to develop an algorithm to classify recorded signals. Overall, 99 features were extracted and statistically analysed using neighborhood component analysis (NCA) to identify the features which showed the greatest ability in classifying recordings. Selected features were then fed to train an ensemble classifier to classify abnormal recordings, and hyperparameters were optimized to evaluate the performance of the trained classifier. Thus, a machine learning-based approach for the automatic identification and classification of S1 and S2, and normal and abnormal recordings, in real-world noisy recordings using a novel feature set is presented. The validity of the proposed algorithm was tested using acoustic signals recorded in real-world, non-controlled environments at four auscultation sites (aortic valve, tricuspid valve, mitral valve, and pulmonary valve), from the subjects with and without cardiac diseases; together with recordings from the three large public databases. The performance metrics of the methodology in relation to classification accuracy (CA), sensitivity (SE), precision (P+), and F1 score, were evaluated. Results: This thesis proposes four different algorithms to automatically classify fundamental heart sounds – S1 and S2; normal fundamental sounds and abnormal additional lub/dub sounds recordings; normal and abnormal recordings; and recordings with heart valve disorders, namely the mitral stenosis (MS), mitral regurgitation (MR), mitral valve prolapse (MVP), aortic stenosis (AS) and murmurs, using cardiac acoustic signals. The results obtained from these algorithms were as follows: • The algorithm to classify S1 and S2 sounds achieved an average SE of 91.59% and 89.78%, and F1 score of 90.65% and 89.42%, in classifying S1 and S2, respectively. 87 features were extracted and statistically studied to identify the top 14 features which showed the best capabilities in classifying S1 and S2, and artifacts. The analysis showed that the most relevant features were those extracted using Maximum Overlap Discrete Wavelet Transform (MODWT) and Hilbert transform. • The algorithm to classify normal fundamental heart sounds and abnormal additional lub/dub sounds in the systole or diastole intervals of a cardiac cycle, achieved an average SE of 89.15%, P+ of 89.71%, F1 of 89.41%, and CA of 95.11% using the test dataset from the PASCAL database. The top 10 features that achieved the highest weights in classifying these recordings were also identified. • Normal and abnormal classification of recordings using the proposed algorithm achieved a mean CA of 94.172%, and SE of 92.38%, in classifying recordings from the different databases. Among the top 10 acoustic features identified, the deterministic energy of the sound peaks of interest and the instantaneous frequency extracted using the Hilbert Huang-transform, achieved the highest weights. • The machine learning-based approach proposed to classify recordings of heart valve disorders (AS, MS, MR, and MVP) achieved an average CA of 98.26% and SE of 95.83%. 99 acoustic features were extracted and their abilities to differentiate these abnormalities were examined using weights obtained from the neighborhood component analysis (NCA). The top 10 features which showed the greatest abilities in classifying these abnormalities using recordings from the different databases were also identified. The achieved results demonstrate the ability of the algorithms to automatically identify and classify cardiac sounds. This work provides the basis for measurements of many useful clinical attributes of cardiac acoustic signals and can potentially help in monitoring the overall cardiac health for longer duration. The work presented in this thesis is the first-of-its-kind to validate the results using both, normal and pathological cardiac acoustic signals, recorded for a long continuous duration of 5 minutes at four different auscultation sites in non-controlled real-world conditions.Open Acces

A Robust Interpretable Deep Learning Classifier for Heart Anomaly Detection Without Segmentation

Traditionally, abnormal heart sound classification is framed as a three-stage process. The first stage involves segmenting the phonocardiogram to detect fundamental heart sounds; after which features are extracted and classification is performed. Some researchers in the field argue the segmentation step is an unwanted computational burden, whereas others embrace it as a prior step to feature extraction. When comparing accuracies achieved by studies that have segmented heart sounds before analysis with those who have overlooked that step, the question of whether to segment heart sounds before feature extraction is still open. In this study, we explicitly examine the importance of heart sound segmentation as a prior step for heart sound classification, and then seek to apply the obtained insights to propose a robust classifier for abnormal heart sound detection. Furthermore, recognizing the pressing need for explainable Artificial Intelligence (AI) models in the medical domain, we also unveil hidden representations learned by the classifier using model interpretation techniques. Experimental results demonstrate that the segmentation plays an essential role in abnormal heart sound classification. Our new classifier is also shown to be robust, stable and most importantly, explainable, with an accuracy of almost 100% on the widely used PhysioNet dataset

Machine Learning and IoT Applied to Cardiovascular Diseases Identification through Heart Sounds: A Literature Review

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Extraction and Assessment of Diagnosis-Relevant Features for Heart Murmur Classification [post-print]

This paper presents a heart murmur detection and multi-class classification approach via machine learning. We extracted heart sound and murmur features that are of diagnostic importance and developed additional 16 features that are not perceivable by human ears but are valuable to improve murmur classification accuracy. We examined and compared the classification performance of supervised machine learning with k-nearest neighbor (KNN) and support vector machine (SVM) algorithms. We put together a test repertoire having more than 450 heart sound and murmur episodes to evaluate the performance of murmur classification using cross-validation of 80–20 and 90–10 splits. As clearly demonstrated in our evaluation, the specific set of features chosen in our study resulted in accurate classification consistently exceeding 90% for both classifiers

An audio processing pipeline for acquiring diagnostic quality heart sounds via mobile phone

Recently, heart sound signals captured using mobile phones have been employed to develop data-driven heart disease detection systems. Such signals are generally captured in person by trained clinicians who can determine if the recorded heart sounds are of diagnosable quality. However, mobile phones have the potential to support heart health diagnostics, even where access to trained medical professionals is limited. To adopt mobile phones as self-diagnostic tools for the masses, we would need to have a mechanism to automatically establish that heart sounds recorded by non-expert users in uncontrolled conditions have the required quality for diagnostic purposes. This paper proposes a quality assessment and enhancement pipeline for heart sounds captured using mobile phones. The pipeline analyzes a heart sound and determines if it has the required quality for diagnostic tasks. Also, in cases where the quality of the captured signal is below the required threshold, the pipeline can improve the quality by applying quality enhancement algorithms. Using this pipeline, we can also provide feedback to users regarding the cause of low-quality signal capture and guide them towards a successful one. We conducted a survey of a group of thirteen clinicians with auscultation skills and experience. The results of this survey were used to inform and validate the proposed quality assessment and enhancement pipeline. We observed a high level of agreement between the survey results and fundamental design decisions within the proposed pipeline. Also, the results indicate that the proposed pipeline can reduce our dependency on trained clinicians for capture of diagnosable heart sounds