Double Cross Magnetic Wall Decoupling for Quadrature Transceiver RF Array Coils using Common-Mode Differential-mode Resonators

In contrast to linearly polarized RF coil arrays, quadrature transceiver coil arrays are capable of improving signal-to-noise ratio (SNR), spatial resolution and parallel imaging performance. Owing to a reduced excitation power, low specific absorption rate can be also obtained using quadrature RF coils. However, due to the complex nature of their structure and their electromagnetic proprieties, it is challenging to achieve sufficient electromagnetic decoupling while designing multichannel quadrature RF coil arrays, particularly at ultrahigh fields. In this work, we proposed a double cross magnetic wall decoupling for quadrature transceiver RF arrays and implemented the decoupling method on common-mode differential mode quadrature (CMDM) quadrature transceiver arrays at ultrahigh field of 7T. The proposed magnetic decoupling wall comprised of two intrinsic decoupled loops is used to reduce the mutual coupling between all the multi-mode current present in the quadrature CMDM array. The decoupling network has no physical connection with the CMDMs' coils giving leverage over size adjustable RF arrays. In order to validate the feasibility of the proposed cross magnetic decoupling wall, systematic studies on the decoupling performance based on the impedance of two intrinsic loops are numerically performed. A pair of quadrature transceiver CMDMs is constructed along with the proposed decoupling network and their scattering matrix is characterized using a network analyzer. The measured results show all the current modes coupling are concurrently suppressed using the proposed cross magnetic wall. Moreover, field distribution, and SNR intensity are numerically obtained for a well-decoupled 8-channel quadrature knee-coil array.Comment: 9 pages, 10 Figure

Design and Simulation of Coils for High Field Magnetic Resonance Imaging and Spectroscopy

The growing availability of high-field magnetic resonance (MR) scanners has reignited interest in the in vivo investigation of metabolics in the body. In particular, multinuclear MR spectroscopy (MRS) data reveal physiological details inaccessible to typical proton (1H) scans. Carbon-13 (13C) MRS studies draw considerable appeal owing to the enhanced chemical shift range of metabolites that may be interrogated to elucidate disease metabolism and progression. To achieve the theoretical signal-to-noise (SNR) gains at high B0 fields, however, J-coupling from 1H-13C chemical bonds must be mitigated by transmitting radiofrequency (RF) proton-decoupling pulses. This irradiated RF power is substantial and intensifies with increased decoupling bandwidth as well as B0 field strength. The preferred 13C MRS experiment, applying broadband proton decoupling, thus presents considerable challenges at 7 T. Localized tissue heating is a paramount concern for all high-field studies, with strict Specific Absorption Rate (SAR) limits in place to ensure patient safety. Transmit coils must operate within these power guidelines without sacrificing image and spectral quality. Consequently, RF coils transmitting proton-decoupling pulses must be expressly designed for power efficiency as well as B1 field homogeneity. This dissertation presents innovations in high-field RF coil development that collectively improved the homogeneity, efficiency, and safety of high field 13C MRS. A review of electromagnetic (EM) theory guided a full-wave modeling study of coplanar shielding geometries to delineate design parameters for coil transmit efficiency. Next, a novel RF coil technique for achieving B1 homogeneity, dubbed forced current excitation (FCE), was examined and a coplanar-shielded FCE coil was implemented for proton decoupling of the breast at 7 T. To perform a series of simulation studies gauging SAR in the prone breast, software was developed to fuse a suite of anatomically-derived heterogeneous breast phantoms, spanning the standard four tissue density classifications, with existing whole-body voxel models. The effects of tissue density on SAR were presented and guidance for simulating the worst-case scenario was outlined. Finally, for improving capabilities of multinuclear coils during proton coil transmit, a high-power trap circuit was designed and tested, ultimately enabling isolation of 13C coil elements during broadband proton decoupling pulses. Together, this work advanced the hardware capabilities of high-field multinuclear spectroscopy with immediate applicability for performing broadband proton-decoupled 13C MRS in the breast at 7 T

Forced Current Excitation in Selectable Field of View Coils for 7T MRI and MRS

High field magnetic resonance imaging (MRI) provides improved signal-to-noise ratio (SNR) which can be translated to higher image resolution or reduced scan time. 7 Tesla (T) breast imaging and 7 T spine imaging are of clinical value, but they are challenging for several reasons: A bilateral breast coil requires the use of closely-spaced elements that are subject to severe mutual coupling which leads to uncontrollable current distribution and non-uniform field pattern; A spine coil at 7T requires a large field of view (FOV) in the z direction and good RF penetration into the human body. Additionally, the ability to switch FOV without the use of expensive high power RF amplifiers is desired in both applications. This capability would allow reconfigurable power distribution and avoid unnecessary heat deposition into human body. Forced-Current Excitation (FCE) is a transmission line-based method that maintains equal current distribution across an array, alleviating mutual coupling effects and allowing current/field replication across a large FOV. At the same time, the nature of this method enables selectable FOV with the inclusion of PIN diodes and a controller. In this doctoral work, the theory of FCE is explained in detail, along with its benefits and drawbacks. Electromagnetic simulation considerations of FCE-driven coils are also discussed. Two FCE-driven coils were designed and implemented: a switchable bilateral/unilateral 7T breast coil, and a segmented dipole for spine imaging at 7T with reconfigurable length. For the breast coil, shielded loop elements were used to form a volume coil, whereas for the spine coil, a segmented dipole was chosen as the final design due to improved RF penetration. Electromagnetic simulations were performed to assist the design of the two coils as well as to predict the SAR (specific absorption rate) generated in the phantom. The coils were evaluated on bench and through MRI experiments in different configurations to validate the design. The switchable breast coil provides uniform excitation in both unilateral and bilateral mode. In unilateral mode, the signal in the contralateral breast is successfully suppressed and higher power is concentrated into the breast of interest; The segmented dipole was compared to a regular dipole with the same length used for 7T spine imaging. The segmented dipole shows a large FOV in the long mode. In the short mode, the residual signal from other part of the dipole is successfully suppressed. The ability to switch FOV and reconfigure the power distribution improves the B1 generated with unit specific absorption rate towards the edge of the dipole, compared to the regular dipole

Forced Current Excitation in Selectable Field of View Coils for 7T MRI and MRS

High field magnetic resonance imaging (MRI) provides improved signal-to-noise ratio (SNR) which can be translated to higher image resolution or reduced scan time. 7 Tesla (T) breast imaging and 7 T spine imaging are of clinical value, but they are challenging for several reasons: A bilateral breast coil requires the use of closely-spaced elements that are subject to severe mutual coupling which leads to uncontrollable current distribution and non-uniform field pattern; A spine coil at 7T requires a large field of view (FOV) in the z direction and good RF penetration into the human body. Additionally, the ability to switch FOV without the use of expensive high power RF amplifiers is desired in both applications. This capability would allow reconfigurable power distribution and avoid unnecessary heat deposition into human body. Forced-Current Excitation (FCE) is a transmission line-based method that maintains equal current distribution across an array, alleviating mutual coupling effects and allowing current/field replication across a large FOV. At the same time, the nature of this method enables selectable FOV with the inclusion of PIN diodes and a controller. In this doctoral work, the theory of FCE is explained in detail, along with its benefits and drawbacks. Electromagnetic simulation considerations of FCE-driven coils are also discussed. Two FCE-driven coils were designed and implemented: a switchable bilateral/unilateral 7T breast coil, and a segmented dipole for spine imaging at 7T with reconfigurable length. For the breast coil, shielded loop elements were used to form a volume coil, whereas for the spine coil, a segmented dipole was chosen as the final design due to improved RF penetration. Electromagnetic simulations were performed to assist the design of the two coils as well as to predict the SAR (specific absorption rate) generated in the phantom. The coils were evaluated on bench and through MRI experiments in different configurations to validate the design. The switchable breast coil provides uniform excitation in both unilateral and bilateral mode. In unilateral mode, the signal in the contralateral breast is successfully suppressed and higher power is concentrated into the breast of interest; The segmented dipole was compared to a regular dipole with the same length used for 7T spine imaging. The segmented dipole shows a large FOV in the long mode. In the short mode, the residual signal from other part of the dipole is successfully suppressed. The ability to switch FOV and reconfigure the power distribution improves the B1 generated with unit specific absorption rate towards the edge of the dipole, compared to the regular dipole

DYNAMIC 31P MRS WITH A 1 TELSA EXTREMITY SCANNER

^31P MRS offers unique non‐invasive access to investigate the in vivo metabolism and is a significant advancement in the understanding and treating of many disease processes. The challenge of in vivo dynamic ^31P MRS mainly originates from the relatively low concentration of phosphorus and the requirement of static magnetic field’s high homogeneity to distinguish the chemical shift of the peaks. Hence, conventional ^31P MRS is usually done in the high field / ultrahigh field whole-body MRI system equipped with multiple channels Bօ shimming coil. On the other hand, extremity NMR scanners which usually have low (<0.5T) or medium (0.5-1T) field strength are often available for a relatively low cost. Those limitations make high temporal resolution dynamic ^31P MRS difficulty using conventional NMR signal acquisition technology in extremity NMR scanners. We propose here using a four-element coil receive-only array and a transmit-only birdcage to investigate the possibility of dynamic ^31P MRS in a 1T ONI extremity scanner. NMR phased array simultaneously acquires multiple channels’ signal from non-interacting receive coils array and subsequently combines the data. In the condition of a poor shimming magnet, another improvement of spectral peak linewidth by replacing single channels coil with multiple smaller channels coils is also studied. A legible spectral is obtained from in vivo volunteers with 4-16 averages, which gives us 16s-64s temporal resolution. The array coil combined SNR is found to be 1.8 times better than using a single loop as a receive coil of the same overall size, and linewidth is improved from 0.72 to 0.45 ppm. This platform shows the potential for monitoring ^31P in vivo metabolism with meaningful temporal resolution in an easy instrument outside of the hospital environment

Application of Parallel Imaging to Murine Magnetic Resonance Imaging

The use of parallel imaging techniques for image acceleration is now common in clinical magnetic resonance imaging (MRI). There has been limited work, however, in translating the parallel imaging techniques to routine animal imaging. This dissertation describes foundational level work to enable parallel imaging of mice on a 4.7 Tesla/40 cm bore research scanner. Reducing the size of the hardware setup associated with typical parallel imaging was an integral part of achieving the work, as animal scanners are typically small-bore systems. To that end, an array element design is described that inherently decouples from a homogenous transmit field, potentially allowing for elimination of typically necessary active detuning switches. The unbalanced feed of this "dual-plane pair" element also eliminates the need for baluns in this case. The use of the element design in a 10-channel adjustable array coil for mouse imaging is presented, styled as a human cardiac top-bottom half-rack design. The design and construction of the homogenous transmit birdcage coil used is also described, one of the necessary components to eliminating the active detuning networks on the array elements. In addition, the design of a compact, modular multi-channel isolation preamplifier board is described, removing the preamplifiers from the elements and saving space in the bore. Several additions/improvements to existing laboratory infrastructure needed for parallel imaging of live mice are also described, including readying an animal preparation area and developing the ability to maintain isoflurane anesthesia delivery during scanning. In addition, the ability to trigger the MRI scanner to the ECG and respiratory signals from the mouse in order to achieve images free from physiological motion artifacts is described. The imaging results from the compact 10-channel mouse array coils are presented, and the challenges associated with the work are described, including difficulty achieving sample-loss dominance and signal-to-noise ratio (SNR) limitations. In conclusion, in vivo imaging of mice with cardiac and respiratory gating has been demonstrated. Compact array coils tailored for mice have been studied and potential future work and design improvements for our lab in this area are discussed

A Method Of Moments Approach for the Design Of RF Coils for MRI

Magnetic Resonance Imaging (MRI) is a widely used soft-tissue imaging modality that has evolved over the past several years into a powerful and versatile medical diagnostic tool capable of providing in-vivo diagnostic images of human and animal anatomies. Current research efforts in MRI system design are driven by the need to obtain detailed high resolution images with improved image signal-to-noise ratio (SNR) at a given magnetic field strength. Invariably, this requirement demands the development of high performance MRI radio frequency (RF) coils. However, the complexities and stringent requirements of modern clinical MRI systems necessitate the development of new modeling methodologies for the design of high performance RF coils. This dissertation addresses this need by developing a distinct Method of Moments (MoM) modeling approach suitable for the simulation of RF coils loaded with biological tissues. The unique implementation utilizes two distinct basis functions in order to collectively describe the surface current density on the RF coil, and the sum of the volume current density and the displacement current density in the associated biological tissue. By selecting basis functions with similar properties to the actual physical quantities they describe, we avoided spurious solutions normally associated with MoM based implementations. The validity of our modeling method was confirmed by comparisons with analytical solutions as well as physical measurements, yielding good agreement. Furthermore, we applied the MoM based modeling method in the design and development of a novel 4-channel receive-only RF coil for breast imaging in a clinical 1.5T system. The new coil design was inspired by the multi-channel array concept, where multiple conducting strips were arranged in an anatomically conforming profile with the intention of improving sensitivity and SNR. In addition, the coil structure featured an open breast coil concept in order to facilitate MRI-guided biopsy and patient comfort. A comparison of simulation results and actual physical measurements from the prototype RF coil demonstrated good agreement with one another. Also, imaging tests were conducted on a pair of MRI phantoms as well as on a human patient after obtaining proper authorization. The tests revealed good magnetic field homogeneity and a high SNR in the region of interest. In addition, performance comparisons between the prototype 4-channel RF coil and existing high end clinical 4-channel RF breast coils indicated an achievement of superior SNR in conjunction with very good magnetic field homogeneity. Currently, the prototype 4-channel RF coil has outperformed all existing high end clinical 4-channel RF coils used in comparison studies

High Impedance Detector Arrays for Magnetic Resonance

Resonant inductive coupling is commonly seen as an undesired fundamental phenomenon emergent in densely packed resonant structures, such as nuclear magnetic resonance phased array detectors. The need to mitigate coupling imposes rigid constraints on the detector design, impeding performance and limiting the scope of magnetic resonance experiments. Here we introduce a high impedance detector design, which can cloak itself from electrodynamic interactions with neighboring elements. We verify experimentally that the high impedance detectors do not suffer from signal-to-noise degradation mechanisms observed with traditional low impedance elements. Using this new-found robustness, we demonstrate an adaptive wearable detector array for magnetic resonance imaging of the hand. The unique properties of the detector glove reveal new pathways to study the biomechanics of soft tissues, and exemplify the enabling potential of high-impedance detectors for a wide range of demanding applications that are not well suited to traditional coil designs.Comment: 16 pages, 12 figures, videos available upon reques

DYNAMIC 31P MRS WITH A 1 TELSA EXTREMITY SCANNER

^31P MRS offers unique non‐invasive access to investigate the in vivo metabolism and is a significant advancement in the understanding and treating of many disease processes. The challenge of in vivo dynamic ^31P MRS mainly originates from the relatively low concentration of phosphorus and the requirement of static magnetic field’s high homogeneity to distinguish the chemical shift of the peaks. Hence, conventional ^31P MRS is usually done in the high field / ultrahigh field whole-body MRI system equipped with multiple channels Bօ shimming coil. On the other hand, extremity NMR scanners which usually have low (<0.5T) or medium (0.5-1T) field strength are often available for a relatively low cost. Those limitations make high temporal resolution dynamic ^31P MRS difficulty using conventional NMR signal acquisition technology in extremity NMR scanners. We propose here using a four-element coil receive-only array and a transmit-only birdcage to investigate the possibility of dynamic ^31P MRS in a 1T ONI extremity scanner. NMR phased array simultaneously acquires multiple channels’ signal from non-interacting receive coils array and subsequently combines the data. In the condition of a poor shimming magnet, another improvement of spectral peak linewidth by replacing single channels coil with multiple smaller channels coils is also studied. A legible spectral is obtained from in vivo volunteers with 4-16 averages, which gives us 16s-64s temporal resolution. The array coil combined SNR is found to be 1.8 times better than using a single loop as a receive coil of the same overall size, and linewidth is improved from 0.72 to 0.45 ppm. This platform shows the potential for monitoring ^31P in vivo metabolism with meaningful temporal resolution in an easy instrument outside of the hospital environment

Multiple resonant multiconductor transmission line resonator design using circulant block matrix algebra

The purpose of this dissertation is to provide a theoretical model to design RF coils using multiconductor transmission line (MTL) structures for MRI applications. In this research, an MTL structure is represented as a multiport network using its port admittance matrix. Resonant conditions and closed-form solutions for different port resonant modes are calculated by solving the eigenvalue problem of port admittance matrix using block matrix algebra. A mathematical proof to show that the solution of the characteristic equation of the port admittance matrix is equivalent to solving the source side input impedance is presented. The proof is derived by writing the transmission chain parameter matrix of an MTL structure, and mathematically manipulating the chain parameter matrix to produce a solution to the characteristic equation of the port admittance matrix. A port admittance matrix can be formulated to take one of the forms depending on the type of MTL structure: a circulant matrix, or a circulant block matrix (CB), or a block circulant circulant block matrix (BCCB). A circulant matrix can be diagonalized by a simple Fourier matrix, and a BCCB matrix can be diagonalized by using matrices formed from Kronecker products of Fourier matrices. For a CB matrix, instead of diagonalizing to compute the eigenvalues, a powerful technique called “reduced dimension method� can be used. In the reduced dimension method, the eigenvalues of a circulant block matrix are computed as a set of the eigenvalues of matrices of reduced dimension. The required reduced dimension matrices are created using a combination of the polynomial representor of a circulant matrix and a permutation matrix. A detailed mathematical formulation of the reduced dimension method is presented in this thesis. With the application of the reduced dimension method for a 2n+1 MTL structure, the computation of eigenvalues for a 4n X 4n port admittance matrix is simplified to the computation of eigenvalues of 2n matrices of size 2 X 2. In addition to reduced computations, the model also facilitates analytical formulations for coil resonant conditions. To demonstrate the effectiveness of the proposed methods (2n port model and reduced dimension method), a two-step approach was adopted. First, a standard published RF coil was analyzed using the proposed models. The obtained resonant conditions are then compared with the published values and are verified by full-wave numerical simulations. Second, two new dual tuned coils, a surface coil design using the 2n port model, and a volume coil design using the reduced dimensions method are proposed, constructed, and bench tested. Their validation was carried out by employing 3D EM simulations as well as undertaking MR imaging on clinical scanners. Imaging experiments were conducted on phantoms, and the investigations indicate that the RF coils achieve good performance characteristics and a high signal-to-noise ratio in the regions of interest