Locally adaptive image denoising by a statistical multiresolution criterion

We demonstrate how one can choose the smoothing parameter in image denoising by a statistical multiresolution criterion, both globally and locally. Using inhomogeneous diffusion and total variation regularization as examples for localized regularization schemes, we present an efficient method for locally adaptive image denoising. As expected, the smoothing parameter serves as an edge detector in this framework. Numerical examples illustrate the usefulness of our approach. We also present an application in confocal microscopy

Identification of partial differential equation models for a class of multiscale spatio-temporal dynamical systems

In this paper, the identification of a class of multiscale spatio-temporal dynamical sys-tems, which incorporate multiple spatial scales, from observations is studied. The proposed approach is a combination of Adams integration and an orthogonal least squares algorithm, in which the multiscale operators are expanded, using polynomials as basis functions, and the spatial derivatives are estimated by finite difference methods. The coefficients of the polynomials can vary with respect to the space domain to represent the feature of multiple scales involved in the system dynamics and are approximated using a B-spline wavelet multi-resolution analysis (MRA). The resulting identified models of the spatio-temporal evolution form a system of partial differential equations with different spatial scales. Examples are provided to demonstrate the efficiency of the proposed method

Identification of time-varying systems using multiresolution wavelet models

Identification of linear and nonlinear time-varying systems is investigated and a new wavelet model identification algorithm is introduced. By expanding each time-varying coefficient using a multiresolution wavelet expansion, the time-varying problem is reduced to a time invariant problem and the identification reduces to regressor selection and parameter estimation. Several examples are included to illustrate the application of the new algorithm

Time-varying parametric modelling and time-dependent spectral characterisation with applications to EEG signals using multi-wavelets

A new time-varying autoregressive (TVAR) modelling approach is proposed for nonstationary signal processing and analysis, with application to EEG data modelling and power spectral estimation. In the new parametric modelling framework, the time-dependent coefficients of the TVAR model are represented using a novel multi-wavelet decomposition scheme. The time-varying modelling problem is then reduced to regression selection and parameter estimation, which can be effectively resolved by using a forward orthogonal regression algorithm. Two examples, one for an artificial signal and another for an EEG signal, are given to show the effectiveness and applicability of the new TVAR modelling method

Fully-Automatic Multiresolution Idealization for Filtered Ion Channel Recordings: Flickering Event Detection

We propose a new model-free segmentation method, JULES, which combines recent statistical multiresolution techniques with local deconvolution for idealization of ion channel recordings. The multiresolution criterion takes into account scales down to the sampling rate enabling the detection of flickering events, i.e., events on small temporal scales, even below the filter frequency. For such small scales the deconvolution step allows for a precise determination of dwell times and, in particular, of amplitude levels, a task which is not possible with common thresholding methods. This is confirmed theoretically and in a comprehensive simulation study. In addition, JULES can be applied as a preprocessing method for a refined hidden Markov analysis. Our new methodolodgy allows us to show that gramicidin A flickering events have the same amplitude as the slow gating events. JULES is available as an R function jules in the package clampSeg

A black-box model for neurons

We explore the identification of neuronal voltage traces by artificial neural networks based on wavelets (Wavenet). More precisely, we apply a modification in the representation of dynamical systems by Wavenet which decreases the number of used functions; this approach combines localized and global scope functions (unlike Wavenet, which uses localized functions only). As a proof-of-concept, we focus on the identification of voltage traces obtained by simulation of a paradigmatic neuron model, the Morris-Lecar model. We show that, after training our artificial network with biologically plausible input currents, the network is able to identify the neuron's behaviour with high accuracy, thus obtaining a black box that can be then used for predictive goals. Interestingly, the interval of input currents used for training, ranging from stimuli for which the neuron is quiescent to stimuli that elicit spikes, shows the ability of our network to identify abrupt changes in the bifurcation diagram, from almost linear input-output relationships to highly nonlinear ones. These findings open new avenues to investigate the identification of other neuron models and to provide heuristic models for real neurons by stimulating them in closed-loop experiments, that is, using the dynamic-clamp, a well-known electrophysiology technique.Peer ReviewedPostprint (author's final draft