Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review article, we report and discuss the three most relevant methodologies for extremely miniaturised implantable neurostimulator: ultrasound coupling, inductive coupling and capacitive coupling. For each powering method, the discussion starts describing the physical working principle. In particular, we focus on the challenges given by the miniaturisation of the implanted integrated circuits and the related ad-hoc solutions for wireless power transfer. Then, we present recent developments and progresses in wireless power transfer for biomedical applications. Last, we compare each technique based on key performance indicators to highlight the most relevant and innovative solutions suitable for neurostimulation, with the gaze turned towards miniaturisation

A design technique for optimizing resonant coils and the energy transfer of inductive links.

Power transfer efficiency (PTE) is a key performance parameter in development work on resonant inductive power transfer (IPT) systems. Geometrically optimizing the transmitter (Tx) and receiver (Rx) coil pair is a way of improving the IPT system's efficiency. In this article, a new figure-of-merit (FoM) is proposed to find an optimum coil geometry which maximizes the PTE. The employed FoM parameter, called the 'strong coupling factor' (Pscf), is defined such that its value indicates how strongly the Tx and Rx coils are linked together. Considering the IPT application and its physical size constraints, a proper selection method for identifying the numerical value of Pscf is essential for optimal coil geometry design. This article presents an iterative algorithm to assist in the selection of the most favorable Pscf value which provides maximized PTE for the designed optimum coil geometry. Design examples of two nominal IPT systems at frequencies of 415 and 0.1 MHz are used to investigate the design algorithm. Theoretical calculations show the optimum geometry designed for the IPT system operating at 415 MHz, with coupling coefficient (K) of 0.2, can achieve maximum PTE of 85.70%. Measurements presented from a practical Tx/Rx coil pair in the IPT link operating at 0.1 MHz, with K=0.05, show a PTE of 83.10% against a calculated PTE of 84.11% validating the design process.This article is an expanded version from the IEEE Wireless Power Week, London, U.K., June 17–20, 2019

Design of Wireless Power Transfer and Data Telemetry System for Biomedical Applications

With the advancement of biomedical instrumentation technologies sensor based remote healthcare monitoring system is gaining more attention day by day. In this system wearable and implantable sensors are placed outside or inside of the human body. Certain sensors are needed to be placed inside the human body to acquire the information on the vital physiological phenomena such as glucose, lactate, pH, oxygen, etc. These implantable sensors have associated circuits for sensor signal processing and data transmission. Powering the circuit is always a crucial design issue. Batteries cannot be used in implantable sensors which can come in contact with the blood resulting in serious health risks. An alternate approach is to supply power wirelessly for tether-less and battery- less operation of the circuits.Inductive power transfer is the most common method of wireless power transfer to the implantable sensors. For good inductive coupling, the inductors should have high inductance and high quality factor. But the physical dimensions of the implanted inductors cannot be large due to a number of biomedical constraints. Therefore, there is a need for small sized and high inductance, high quality factor inductors for implantable sensor applications. In this work, design of a multi-spiral solenoidal printed circuit board (PCB) inductor for biomedical application is presented. The targeted frequency for power transfer is 13.56 MHz which is within the license-free industrial, scientific and medical (ISM) band. A figure of merit based optimization technique has been utilized to optimize the PCB inductors. Similar principal is applied to design on-chip inductor which could be a potential solution for further miniaturization of the implantable system. For layered human tissue the optimum frequency of power transfer is 1 GHz for smaller coil size. For this reason, design and optimization of multi-spiral solenoidal integrated inductors for 1 GHz frequency is proposed. Finally, it is demonstrated that the proposed inductors exhibit a better overall performance in comparison with the conventional inductors for biomedical applications

A design technique for geometric optimisation of resonant coil sizes in low to mid frequency inductive power transmission systems.

Wireless power transfer (WPT) is a well-established method of energising electrically-powered devices. Among the different available WPT techniques, Resonant Inductive Power Transfer (RIPT) has been adapted for use in a wide range of applications. The primary reason is the relatively higher Power Transfer Efficiency (PTE) that RIPT can provide. RIPT systems operate on the principle of magnetic resonance coupling between a Transmitter (Tx) and a Receiver (Rx) coil. Maximising the PTE is a key driver for improving the performance of RIPT systems. In a RIPT link the PTE is influenced by three factors: (i) inductive linkage between the Tx and Rx, (ii) terminating circuitry of Tx and Rx sides and (iii) the Tx/Rx coil's geometrical size. In considering these impacting factors, different techniques to improve PTE have been extensively presented in the literature and are comprehensively reviewed in this thesis. The research work undertaken focuses on the geometrical optimisation of Tx/Rx coils to help maximise PTE in RIPT systems for operation over low- and mid-frequency bands (i.e. between few kHz to several MHz). Conventional methods for maximising PTE require defining various design parameters (i.e. figure-of-merits), which assist in finding the optimum Air-Cored Coil (ACC) geometry. However, traditional techniques for working with Figure-of-Merit (FoM) parameters are very time-consuming and process-demanding. In this thesis, the number of required FoMs have been reduced to one and incorporated into a process that will accelerate production of the optimum geometry design. A unique FoM parameter (i.e. Pscf) is developed by consolidating the PTE's impacting factors. Considering the RIPT application and its physical size constraints, a proper selection method for identifying the numerical value of Pscf is investigated. A novel iterative algorithm has been developed to assist in selection of the most favourable Pscf value, which provides the optimum ACC geometry. Theoretical design examples of two RIPT systems - operating at 10 kHz (low-frequency band) and 300 kHz (mid-frequency band) - are used to investigate the functionality of the ACC design approach, for which successful results are achieved. The novel iterative algorithm is also experimentally validated by developing four prototyped Tx/Rx ACC pairs, with real-world applications, which operate over low- and mid-frequency bands: 1:06 MHz, 100 kHz, 50 kHz, 15 kHz. For the designed ACC geometries, maximum PTEs of 85:63% at 1:06 MHz, 83:10% at 100 kHz, 72:85% at 50 kHz and 34:57% at 15 kHz are practically measured in bench top tests. The measured PTE values are in close correlation (within 14%) with the calculated PTEs at these frequency ranges, and thus validate the novel ACC design procedure. The RIPT system's maximum achievable PTE can be further increased by adding ferrite cores to the Tx/Rx ACC pair. In this thesis, an advanced iterative algorithm is also presented to support the design of geometrically optimised coil pairs employing ferrite cores. The advanced iterative algorithm is an extension of the initial work on optimising ACC geometries. Optimum Ferrite-Cored Coil (FCC) geometries, produced using the advanced iterative algorithm, for RIPT systems operating at 10 kHz and 300 kHz have been investigated. In comparing the FCC and ACC geometries designed for these frequencies, it is demonstrated that RIPT systems with ferrite cores reduce the ACC's geometrical size and additionally improve PTE. To validate the performance of the advanced FCC design algorithm over low- and mid-frequency bands, two RIPT systems are physically constructed for operation at 15 kHz (low-frequency) and 50 kHz (mid-frequency). For the prototyped RIPT systems, maximum PTEs of 45:16% at 50 kHz and 50:74% at 15 kHz are practically measured. The calculated and physically measured PTE values are within 2% difference; hence validating the advanced FCC design process

Wireless Power Transfer Techniques for Implantable Medical Devices:A Review

Wireless power transfer (WPT) systems have become increasingly suitable solutions for the electrical powering of advanced multifunctional micro-electronic devices such as those found in current biomedical implants. The design and implementation of high power transfer efficiency WPT systems are, however, challenging. The size of the WPT system, the separation distance between the outside environment and location of the implanted medical device inside the body, the operating frequency and tissue safety due to power dissipation are key parameters to consider in the design of WPT systems. This article provides a systematic review of the wide range of WPT systems that have been investigated over the last two decades to improve overall system performance. The various strategies implemented to transfer wireless power in implantable medical devices (IMDs) were reviewed, which includes capacitive coupling, inductive coupling, magnetic resonance coupling and, more recently, acoustic and optical powering methods. The strengths and limitations of all these techniques are benchmarked against each other and particular emphasis is placed on comparing the implanted receiver size, the WPT distance, power transfer efficiency and tissue safety presented by the resulting systems. Necessary improvements and trends of each WPT techniques are also indicated per specific IMD

A Novel Power-Efficient Wireless Multi-channel Recording System for the Telemonitoring of Electroencephalography (EEG)

This research introduces the development of a novel EEG recording system that is modular, batteryless, and wireless (untethered) with the supporting theoretical foundation in wireless communications and related design elements and circuitry. Its modular construct overcomes the EEG scaling problem and makes it easier for reconfiguring the hardware design in terms of the number and placement of electrodes and type of standard EEG system contemplated for use. In this development, portability, lightweight, and applicability to other clinical applications that rely on EEG data are sought. Due to printer tolerance, the 3D printed cap consists of 61 electrode placements. This recording capacity can however extend from 21 (as in the international 10-20 systems) up to 61 EEG channels at sample rates ranging from 250 to 1000 Hz and the transfer of the raw EEG signal using a standard allocated frequency as a data carrier. The main objectives of this dissertation are to (1) eliminate the need for heavy mounted batteries, (2) overcome the requirement for bulky power systems, and (3) avoid the use of data cables to untether the EEG system from the subject for a more practical and less restrictive setting. Unpredictability and temporal variations of the EEG input make developing a battery-free and cable-free EEG reading device challenging. Professional high-quality and high-resolution analog front ends are required to capture non-stationary EEG signals at microvolt levels. The primary components of the proposed setup are the wireless power transmission unit, which consists of a power amplifier, highly efficient resonant-inductive link, rectification, regulation, and power management units, as well as the analog front end, which consists of an analog to digital converter, pre-amplification unit, filtering unit, host microprocessor, and the wireless communication unit. These must all be compatible with the rest of the system and must use the least amount of power possible while minimizing the presence of noise and the attenuation of the recorded signal A highly efficient resonant-inductive coupling link is developed to decrease power transmission dissipation. Magnetized materials were utilized to steer electromagnetic flux and decrease route and medium loss while transmitting the required energy with low dissipation. Signal pre-amplification is handled by the front-end active electrodes. Standard bio-amplifier design approaches are combined to accomplish this purpose, and a thorough investigation of the optimum ADC, microcontroller, and transceiver units has been carried out. We can minimize overall system weight and power consumption by employing battery-less and cable-free EEG readout system designs, consequently giving patients more comfort and freedom of movement. Similarly, the solutions are designed to match the performance of medical-grade equipment. The captured electrical impulses using the proposed setup can be stored for various uses, including classification, prediction, 3D source localization, and for monitoring and diagnosing different brain disorders. All the proposed designs and supporting mathematical derivations were validated through empirical and software-simulated experiments. Many of the proposed designs, including the 3D head cap, the wireless power transmission unit, and the pre-amplification unit, are already fabricated, and the schematic circuits and simulation results were based on Spice, Altium, and high-frequency structure simulator (HFSS) software. The fully integrated head cap to be fabricated would require embedding the active electrodes into the 3D headset and applying current technological advances to miniaturize some of the design elements developed in this dissertation

A Multi-Dimensional Analysis of a Novel Approach for Wireless Stimulation

The elimination of integrated batteries in biomedical implants holds great promise for improving health outcomes in patients with implantable devices. However, despite extensive research in wireless power transfer, achieving efficient power transfer and effective operational range have remained a hindering challenge within anatomical constraints. Objective : We hereby demonstrate an intravascular wireless and batteryless microscale stimulator, designed for (1) low power dissipation via intermittent transmission and (2) reduced fixation mechanical burden via deployment to the anterior cardiac vein (ACV, ∼3.8 mm in diameter). Methods : We introduced a unique coil design circumferentially confined to a 3 mm diameter hollow-cylinder that was driven by a novel transmitter-based control architecture with improved power efficiency. Results : We examined wireless capacity using heterogenous bovine tissue, demonstrating >5 V stimulation threshold with up to 20 mm transmitter-receiver displacement and 20° of misalignment. Feasibility for human use was validated using Finite Element Method (FEM) simulation of the cardiac cycle, guided by pacer phantom-integrated Magnetic Resonance Images (MRI). Conclusion : This system design thus enabled sufficient wireless power transfer in the face of extensive stimulator miniaturization. Significance : Our successful feasibility studies demonstrated the capacity for minimally invasive deployment and low-risk fixation

A Multi-Dimensional Analysis of a Novel Approach for Wireless Stimulation

The elimination of integrated batteries in biomedical implants holds great promise for improving health outcomes in patients with implantable devices. However, despite extensive research in wireless power transfer, achieving efficient power transfer and effective operational range have remained a hindering challenge within anatomical constraints. Objective : We hereby demonstrate an intravascular wireless and batteryless microscale stimulator, designed for (1) low power dissipation via intermittent transmission and (2) reduced fixation mechanical burden via deployment to the anterior cardiac vein (ACV, ∼3.8 mm in diameter). Methods : We introduced a unique coil design circumferentially confined to a 3 mm diameter hollow-cylinder that was driven by a novel transmitter-based control architecture with improved power efficiency. Results : We examined wireless capacity using heterogenous bovine tissue, demonstrating >5 V stimulation threshold with up to 20 mm transmitter-receiver displacement and 20° of misalignment. Feasibility for human use was validated using Finite Element Method (FEM) simulation of the cardiac cycle, guided by pacer phantom-integrated Magnetic Resonance Images (MRI). Conclusion : This system design thus enabled sufficient wireless power transfer in the face of extensive stimulator miniaturization. Significance : Our successful feasibility studies demonstrated the capacity for minimally invasive deployment and low-risk fixation