High-performance detection of epilepsy in seizure-free EEG recordings: A novel machine learning approach using very specific epileptic EEG sub-bands

We applied machine learning to diagnose epilepsy based on the fine-graded spectral analysis of seizure-free (resting state) EEG recordings. Despite using unspecific agglomerated EEG spectra, our fine-graded spectral analysis specifically identified the two EEG resting state sub-bands differentiating healthy people from epileptics (1.5-2 Hz and 11-12.5 Hz). The rigorous evaluation of completely unseen data of 100 EEG recordings (50 belonging to epileptics and the other 50 to healthy people) shows that the approach works successfully, achieving an outstanding accuracy of 99 percent, which significantly outperforms the current benchmark of 70% to 95% by a panel of up to three experienced neurologists. Our epilepsy diagnosis classifier can be implemented in modern EEG analysis devices, especially in intensive care units where early diagnosis and appropriate treatment are decisive in life and death scenarios and where physicians’ error rates are particularly high. Our approach is accurate, robust, fast, and cost-efficient and substantially contributes to Information Systems research in healthcare. The approach is also of high practical and theoretical relevance

How to Conduct Rigorous Supervised Machine Learning in Information Systems Research: The Supervised Machine Learning Reportcard [in press]

Within the last decade, the application of supervised machine learning (SML) has become increasingly popular in the field of information systems (IS) research. Although the choices among different data preprocessing techniques, as well as different algorithms and their individual implementations, are fundamental building blocks of SML results, their documentation—and therefore reproducibility—is inconsistent across published IS research papers. This may be quite understandable, since the goals and motivations for SML applications vary and since the field has been rapidly evolving within IS. For the IS research community, however, this poses a big challenge, because even with full access to the data neither a complete evaluation of the SML approaches nor a replication of the research results is possible. Therefore, this article aims to provide the IS community with guidelines for comprehensively and rigorously conducting, as well as documenting, SML research: First, we review the literature concerning steps and SML process frameworks to extract relevant problem characteristics and relevant choices to be made in the application of SML. Second, we integrate these into a comprehensive “Supervised Machine Learning Reportcard (SMLR)” as an artifact to be used in future SML endeavors. Third, we apply this reportcard to a set of 121 relevant articles published in renowned IS outlets between 2010 and 2018 and demonstrate how and where the documentation of current IS research articles can be improved. Thus, this work should contribute to a more complete and rigorous application and documentation of SML approaches, thereby enabling a deeper evaluation and reproducibility / replication of results in IS research

A Data-analytical System to Predict Therapy Success for Obese Children

Childhood obesity is an increasingly pervasive problem. Traditional therapy programs are time- and cost-intensive. Furthermore, success of therapy is often not guaranteed. Typically, success of therapies is determined by comparison of body mass index (BM

Validation of design artefacts for blockchain-enabled precision healthcare as a service.

Healthcare systems around the globe are currently experiencing a rapid wave of digital disruption. Current research in applying emerging technologies such as Big Data (BD), Artificial Intelligence (AI), Machine Learning (ML), Deep Learning (DL), Augmented Reality (AR), Virtual Reality (VR), Digital Twin (DT), Wearable Sensor (WS), Blockchain (BC) and Smart Contracts (SC) in contact tracing, tracking, drug discovery, care support and delivery, vaccine distribution, management, and delivery. These disruptive innovations have made it feasible for the healthcare industry to provide personalised digital health solutions and services to the people and ensure sustainability in healthcare. Precision Healthcare (PHC) is a new inclusion in digital healthcare that can support personalised needs. It focuses on supporting and providing precise healthcare delivery. Despite such potential, recent studies show that PHC is ineffectual due to the lower patient adoption in the system. Anecdotal evidence shows that people are refraining from adopting PHC due to distrust. This thesis presents a BC-enabled PHC ecosystem that addresses ongoing issues and challenges regarding low opt-in. The designed ecosystem also incorporates emerging information technologies that are potential to address the need for user-centricity, data privacy and security, accountability, transparency, interoperability, and scalability for a sustainable PHC ecosystem. The research adopts Soft System Methodology (SSM) to construct and validate the design artefact and sub-artefacts of the proposed PHC ecosystem that addresses the low opt-in problem. Following a comprehensive view of the scholarly literature, which resulted in a draft set of design principles and rules, eighteen design refinement interviews were conducted to develop the artefact and sub-artefacts for design specifications. The artefact and sub-artefacts were validated through a design validation workshop, where the designed ecosystem was presented to a Delphi panel of twenty-two health industry actors. The key research finding was that there is a need for data-driven, secure, transparent, scalable, individualised healthcare services to achieve sustainability in healthcare. It includes explainable AI, data standards for biosensor devices, affordable BC solutions for storage, privacy and security policy, interoperability, and usercentricity, which prompts further research and industry application. The proposed ecosystem is potentially effective in growing trust, influencing patients in active engagement with real-world implementation, and contributing to sustainability in healthcare