5 research outputs found
Stacked Penalized Logistic Regression for Selecting Views in Multi-View Learning
In biomedical research, many different types of patient data can be
collected, such as various types of omics data and medical imaging modalities.
Applying multi-view learning to these different sources of information can
increase the accuracy of medical classification models compared with
single-view procedures. However, collecting biomedical data can be expensive
and/or burdening for patients, so that it is important to reduce the amount of
required data collection. It is therefore necessary to develop multi-view
learning methods which can accurately identify those views that are most
important for prediction. In recent years, several biomedical studies have used
an approach known as multi-view stacking (MVS), where a model is trained on
each view separately and the resulting predictions are combined through
stacking. In these studies, MVS has been shown to increase classification
accuracy. However, the MVS framework can also be used for selecting a subset of
important views. To study the view selection potential of MVS, we develop a
special case called stacked penalized logistic regression (StaPLR). Compared
with existing view-selection methods, StaPLR can make use of faster
optimization algorithms and is easily parallelized. We show that nonnegativity
constraints on the parameters of the function which combines the views play an
important role in preventing unimportant views from entering the model. We
investigate the performance of StaPLR through simulations, and consider two
real data examples. We compare the performance of StaPLR with an existing view
selection method called the group lasso and observe that, in terms of view
selection, StaPLR is often more conservative and has a consistently lower false
positive rate.Comment: 26 pages, 9 figures. Accepted manuscrip
Analyzing hierarchical multi-view MRI data with StaPLR: An application to Alzheimer's disease classification
Multi-view data refers to a setting where features are divided into feature
sets, for example because they correspond to different sources. Stacked
penalized logistic regression (StaPLR) is a recently introduced method that can
be used for classification and automatically selecting the views that are most
important for prediction. We introduce an extension of this method to a setting
where the data has a hierarchical multi-view structure. We also introduce a new
view importance measure for StaPLR, which allows us to compare the importance
of views at any level of the hierarchy. We apply our extended StaPLR algorithm
to Alzheimer's disease classification where different MRI measures have been
calculated from three scan types: structural MRI, diffusion-weighted MRI, and
resting-state fMRI. StaPLR can identify which scan types and which derived MRI
measures are most important for classification, and it outperforms elastic net
regression in classification performance.Comment: 36 pages, 9 figures. Accepted manuscrip
Analyzing hierarchical multi-view MRI data with StaPLR: an application to Alzheimer's disease classification
Multivariate analysis of psychological dat
Analyzing hierarchical multi-view MRI Data With StaPLR An Application to Alzheimer's disease classification: an application to Alzheimer's disease classification
Multi-view data refers to a setting where features are divided into feature sets, for example because they correspond to different sources. Stacked penalized logistic regression (StaPLR) is a recently introduced method that can be used for classification and automatically selecting the views that are most important for prediction. We introduce an extension of this method to a setting where the data has a hierarchical multi-view structure. We also introduce a new view importance measure for StaPLR, which allows us to compare the importance of views at any level of the hierarchy. We apply our extended StaPLR algorithm to Alzheimer's disease classification where different MRI measures have been calculated from three scan types: structural MRI, diffusion-weighted MRI, and resting-state fMRI. StaPLR can identify which scan types and which derived MRI measures are most important for classification, and it outperforms elastic net regression in classification performance. Horizon 2020(H2020)101041064Multivariate analysis of psychological dat
A case study of stacked multi-view learning in dementia research
Classification of different types of dementia commonly involves examination from several perspectives, e.g., medical images, neuropsychological tests, etc. Thus, dementia classification should lend itself to so-called multi-view learning. Instead of simply combining several views, we use stacking to make the most of the information from the various views (PET scans, MMSE, CERAD and demographic variables). In the paper, we not only show the performance of stacked multi-view learning on classifying dementia data, we also try to explain the factors contributing to its performance. More specifically, we show that the correlation of views on the base and the meta level should be within certain ranges to facilitate successful stacked multi-view learning