40,275 research outputs found
A universal approach for drainage basins
Drainage basins are essential to Geohydrology and Biodiversity. Defining
those regions in a simple, robust and efficient way is a constant challenge in
Earth Science. Here, we introduce a model to delineate multiple drainage basins
through an extension of the Invasion Percolation-Based Algorithm (IPBA). In
order to prove the potential of our approach, we apply it to real and
artificial datasets. We observe that the perimeter and area distributions of
basins and anti-basins display long tails extending over several orders of
magnitude and following approximately power-law behaviors. Moreover, the
exponents of these power laws depend on spatial correlations and are invariant
under the landscape orientation, not only for terrestrial, but lunar and
martian landscapes. The terrestrial and martian results are statistically
identical, which suggests that a hypothetical martian river would present
similarity to the terrestrial rivers. Finally, we propose a theoretical value
for the Hack's exponent based on the fractal dimension of watersheds,
. We measure for Earth, which is close to
our estimation of . Our study suggests that Hack's law can
have its origin purely in the maximum and minimum lines of the landscapes.Comment: 20 pages, 6 Figures, and 1 Tabl
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An Empirical Study of the Effectiveness of 'Forcing Diversity' Based on a Large Population of Diverse Programs
Use of diverse software components is a viable defence against common-mode failures in redundant softwarebased systems. Various forms of "Diversity-Seeking Decisions" (âDSDsâ) can be applied to the process of developing, or procuring, redundant components, to improve the chances of the resulting components not failing on the same demands. An open question is how effective these decisions, and their combinations, are for achieving large enough reliability gains. Using a large population of software programs, we studied experimentally the effectiveness of specific "DSDs" (and their combinations) mandating differences between redundant components. Some of these combinations produced much better improvements in system probability of failure per demand (PFD) than "uncontrolled" diversity did. Yet, our findings suggest that the gains from such "DSDs" vary significantly between them and between the application problems studied. The relationship between DSDs and system PFD is complex and does not allow for simple universal rules
(e.g. "the more diversity the better") to apply
Adaptive development and maintenance of user-centric software systems
A software system cannot be developed without considering the various facets of its environment. Stakeholders â including the users that play a central role â have their needs, expectations, and perceptions of a system. Organisational and technical aspects of the environment are constantly changing. The ability to adapt a software system and its requirements to its environment throughout its
full lifecycle is of paramount importance in a constantly changing environment. The continuous involvement of users is as important as the constant evaluation of the system and the observation of evolving environments. We present a methodology for adaptive software systems development and
maintenance. We draw upon a diverse range of accepted methods including participatory design, software architecture, and evolutionary design. Our focus is on user-centred software systems
A methodological comparison between energy and environmental performance evaluation
The European Union is working on strategies in order to increase the energy efficiency of buildings. A useful solution is to identify the energy performance of buildings through the Energy Performance Certificate (EPC), as it provides information for the comparison of buildings with different architectural typology, shape, design technology and geographic location. However, this tool does not assess the real energy consumption of the building and does not always take into account its impact on the environment. In this work, two different types of analysis were carried out: one based only on the energy efficiency and the other one based on the environmental impact. Those analyses were applied on a standard building, set in three different Italian locations, with the purpose of obtaining cross-related information. After the evaluation of the results, interventions on some parameters (walls insulation, windows frame, filler gas in the insulated glazing) have been identified in order to improve the energy behavior of the building with an acceptable environmental impact. The aim of this paper is to propose a methodology that integrates the EPC with green building rating systems, leading to a more conscious choice of retrofit interventions as a compromise between energy performances and environmental impact
Computing Substrates and Life
Alive matter distinguishes itself from inanimate matter by actively maintaining a high degree of inhomogenous organisation. Information processing is quintessential to this capability. The present paper inquires into the degree to which the information processing aspect of living systems can be abstracted from the physical medium of its implementation. Information processing serving to sustain the complex organisation of a living system faces both the harsh reality of real-time requirements and severe constraints on energy and material that can be expended on the task. This issue is of interest for the potential scope of Artificial Life and its interaction with Synthetic Biology. It is pertinent also for information technology. With regard to the latter aspect, the use of a living cell in a robot control architecture is considered
An improved Plasmodium cynomolgi genome assembly reveals an unexpected methyltransferase gene expansion.
Background: Plasmodium cynomolgi, a non-human primate malaria parasite species, has been an important model parasite since its discovery in 1907. Similarities in the biology of P. cynomolgi to the closely related, but less tractable, human malaria parasite P. vivax make it the model parasite of choice for liver biology and vaccine studies pertinent to P. vivax malaria. Molecular and genome-scale studies of P. cynomolgi have relied on the current reference genome sequence, which remains highly fragmented with 1,649 unassigned scaffolds and little representation of the subtelomeres.
Methods: Using long-read sequence data (Pacific Biosciences SMRT technology), we assembled and annotated a new reference genome sequence, PcyM, sourced from an Indian rhesus monkey. We compare the newly assembled genome sequence with those of several other Plasmodium species, including a re-annotated P. coatneyi assembly.
Results: The new PcyM genome assembly is of significantly higher quality than the existing reference, comprising only 56 pieces, no gaps and an improved average gene length. Detailed manual curation has ensured a comprehensive annotation of the genome with 6,632 genes, nearly 1,000 more than previously attributed to P. cynomolgi. The new assembly also has an improved representation of the subtelomeric regions, which account for nearly 40% of the sequence. Within the subtelomeres, we identified more than 1300 Plasmodium interspersed repeat (pir) genes, as well as a striking expansion of 36 methyltransferase pseudogenes that originated from a single copy on chromosome 9.
Conclusions: The manually curated PcyM reference genome sequence is an important new resource for the malaria research community. The high quality and contiguity of the data have enabled the discovery of a novel expansion of methyltransferase in the subtelomeres, and illustrates the new comparative genomics capabilities that are being unlocked by complete reference genomes
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