Impact of Ear Occlusion on In-Ear Sounds Generated by Intra-oral Behaviors

We conducted a case study with one volunteer and a recording setup to detect sounds induced by the actions: jaw clenching, tooth grinding, reading, eating, and drinking. The setup consisted of two in-ear microphones, where the left ear was semi-occluded with a commercially available earpiece and the right ear was occluded with a mouldable silicon ear piece. Investigations in the time and frequency domains demonstrated that for behaviors such as eating, tooth grinding, and reading, sounds could be recorded with both sensors. For jaw clenching, however, occluding the ear with a mouldable piece was necessary to enable its detection. This can be attributed to the fact that the mouldable ear piece sealed the ear canal and isolated it from the environment, resulting in a detectable change in pressure. In conclusion, our work suggests that detecting behaviors such as eating, grinding, reading with a semi-occluded ear is possible, whereas, behaviors such as clenching require the complete occlusion of the ear if the activity should be easily detectable. Nevertheless, the latter approach may limit real-world applicability because it hinders the hearing capabilities.</p

Goddard Visiting Scientist Program for the Space and Earth Sciences Directorate

Progress reports of the Visiting Scientist Program covering the period from 1 Jul. - 30 Sep. 1992 are included. Topics covered include space science and earth science. Other topics covered include cosmic rays, magnetic clouds, solar wind, satellite data, high resolution radiometer, and microwave scattering

The design and implementation of a purely digital stereo-photogrammetric system on the IBM 3090 multi-user mainframe computer

This thesis is concerned with an investigation into the possibilities of implementing various aspects of a purely digital stereo-photogrammetric (DSP) system on the IBM 3090 150E mainframe multi-user computer. The main aspects discussed within the context of this thesis are:-i) Mathematical modelling of the process of formation of digital images in the space and frequency domains.ii) Experiments on improving the pictorial quality of digital aerial photos using Inverse and Wiener filters.iii) Devising and implementing an approach for the automatic sub-pixel measurement of cross-type fiducial marks for the inner orientation, using the Gradient operator and image modelling least squares (IML) approach.iv) Devising and implementing a method for the digital rectification of overlapping aerial photos and the formation of the stereo-model.v) Design and implementation of a digital stereo-photogrammetric system (DSP) and the generation of a DTM using visual measurement.vi) Investigating the feasibility of stereo-viewing of binary images and the possibility of performing measurements on such images.vii) Implementing a method for the automatic generation of a DTM using a one-dimensional image correlation along epipolar lines and experimentally optimizing the size of the correlation window.viii) Assessment of the accuracy of the DTM data generated both by the DSP and the automatic correlation method.ix) Vectorization of the rectification and correlation programs to achieve higher speed-up factors in the computational process

43rd Rocky Mountain Conference on Analytical Chemistry

Final program, abstracts, and information about the 43rd annual meeting of the Rocky Mountain Conference on Analytical Chemistry, co-sponsored by the Colorado Section of the American Chemical Society and the Rocky Mountain Section of the Society for Applied Spectroscopy. Held in Denver, Colorado, July 29 - August 2, 2001

[¹⁸F]fluorination of biorelevant arylboronic acid pinacol ester scaffolds synthesized by convergence techniques

Aim: The development of small molecules through convergent multicomponent reactions (MCR) has been boosted during the last decade due to the ability to synthesize, virtually without any side-products, numerous small drug-like molecules with several degrees of structural diversity.(1) The association of positron emission tomography (PET) labeling techniques in line with the “one-pot” development of biologically active compounds has the potential to become relevant not only for the evaluation and characterization of those MCR products through molecular imaging, but also to increase the library of radiotracers available. Therefore, since the [18F]fluorination of arylboronic acid pinacol ester derivatives tolerates electron-poor and electro-rich arenes and various functional groups,(2) the main goal of this research work was to achieve the 18F-radiolabeling of several different molecules synthesized through MCR. Materials and Methods: [18F]Fluorination of boronic acid pinacol esters was first extensively optimized using a benzaldehyde derivative in relation to the ideal amount of Cu(II) catalyst and precursor to be used, as well as the reaction solvent. Radiochemical conversion (RCC) yields were assessed by TLC-SG. The optimized radiolabeling conditions were subsequently applied to several structurally different MCR scaffolds comprising biologically relevant pharmacophores (e.g. β-lactam, morpholine, tetrazole, oxazole) that were synthesized to specifically contain a boronic acid pinacol ester group. Results: Radiolabeling with fluorine-18 was achieved with volumes (800 μl) and activities (≤ 2 GBq) compatible with most radiochemistry techniques and modules. In summary, an increase in the quantities of precursor or Cu(II) catalyst lead to higher conversion yields. An optimal amount of precursor (0.06 mmol) and Cu(OTf)2(py)4 (0.04 mmol) was defined for further reactions, with DMA being a preferential solvent over DMF. RCC yields from 15% to 76%, depending on the scaffold, were reproducibly achieved. Interestingly, it was noticed that the structure of the scaffolds, beyond the arylboronic acid, exerts some influence in the final RCC, with electron-withdrawing groups in the para position apparently enhancing the radiolabeling yield. Conclusion: The developed method with high RCC and reproducibility has the potential to be applied in line with MCR and also has a possibility to be incorporated in a later stage of this convergent “one-pot” synthesis strategy. Further studies are currently ongoing to apply this radiolabeling concept to fluorine-containing approved drugs whose boronic acid pinacol ester precursors can be synthesized through MCR (e.g. atorvastatin)

A Method for Global-Scale Archiving of Imaging Data Based on QTM Pixels

A global multi-resolution image data model and a feasible solution for its seamless management and archiving remain a challenging vision. The traditional methods of the raster pixel data structure based on the idea of map projections are effective to support local or small-scale areas. However, if this structure is applied to large-scale or whole global image archiving, some significant drawbacks are unavoidable, such as data discontinuity (or overlapping), geometric distortions, etc. To overcome these deficiencies, in this paper the Quaternary Triangular Mesh (QTM) (Dutton, 1989), as a continuous, hierarchal quadtree data structure with uniform grids on a sphere, is proposed for global-scale seamless image archiving. First, the mapping relation between raster image pixels and QTM pixels is approached based on the QTM subdivision and Quaternary coding scheme (Bartholdi & Goldsman, 2001), and a corresponding algorithm of QTM pixel grey level calculation is also developed. Then, the storage structure of global-scale image archiving based on QTM pixels is presented in detail. In the end, an experiment is described using the 1km resolution NOAA data for China, comparing the differences in pixel grey levels between original image pixels and QTM pixels. The result indicates that the QTM pixel data structure can keep global-scale images seamless, and the accuracy of transformation from the imaging pixel to the QTM pixel is a loss of less than 2 grey levels for 94.5% of all pixels, the loss from 2 to 4 is 1.9%, the loss from 4 to 10 is 2%, and the rest is 1.6%. The results are good and acceptable

Exploring the Unknown: Selected Documents in the History of the US Civilian Space Program

One of the most important developments of the twentieth century has been the movement of humanity into space with machines and people. The underpinnings of that movement -why it took the shape it did; which individuals and organizations were involved; what factors drove a particular choice of scientific objectives and technologies to be used; and the political, economic, managerial, and international contexts in which the events of the space age unfolded- are all important ingredients of this epoch transition from an earthbound to spacefaring people. This desire to understand the development of spaceflight in the United States sparked this documentary history series. 'Exploring the Unknown' is a multi-volume series containing a selection of key documents in history of the U.S. civil space program. This current volume, Volume III, focusing on the use of space for practical applications, prints 112 key documents on the history of satellite communications, remote sensing of earth, and space as an investment in economic growth, edited for ease of use. Each is introduced by a headnote providing context, bibliographical information, and background information necessary to understanding the document