Dish Stirling solar receiver program

A technology demonstration of a Dish Stirling solar thermal electric system can be accomplished earlier and at a much lower cost than previous planning had indicated by employing technical solutions that allow already existing hardware, with minimum modifications, to be integrated into a total system with a minimum of development. The DSSR operates with a modified United Stirling p-40 engine/alternator and the JPL Test Bed Concentrator as a completely integrated solar thermal electric system having a design output of 25 kWe. The system is augmented by fossil fuel combustion which ensures a continuous electrical output under all environmental conditions. Technical and economic studies by government and industry in the United States and abroad identify the Dish Stirling solar electric system as the most appropriate, efficient and economical method for conversion of solar energy to electricity in applications when the electrical demand is 10 MWe and less

Portland Daily Press: November 27, 1900

https://digitalmaine.com/pdp_1900/1281/thumbnail.jp

Aerospace Medicine and Biology: a Continuing Bibliography with Indexes (supplement 330)

This bibliography lists 156 reports, articles, and other documents introduced into the NASA Scientific and Technical Information System during November 1989. Subject coverage includes: aerospace medicine and psychology, life support system and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance

State of New Hampshire. Reports, 1911-1912, volume III.- Biennial

Sometimes issued both annually and biennially; Each vol. contains the reports of various departments of the government of the state of New Hampshire; Includes attorneys general\u27s opinion

Report of the Secretary of War; being part of the message and documents communicated to the two Houses of Congress at the beginning of the second session of the Fifty-second Congress, 1892

Annual Message to Congress with Documents; Pres. Harrison. 6 Dec. HED 1, 52-2, v1-22 , 16378p. [3076-3097] Cession of the Cherokee Strip and other Indian lands to the U.S.; policy of allotment and education; Choctaw and Chickasaw title to lands occupied by other tribes; annual report of the Sec. of War (Serials 3077-3084); annual report of the Sec. of Interior (Serials 3087-3094); annual report of the Gen. Land Office (Serial 3087) ; annual report of the CIA (Serial 3088); etc

A Mechanistic Investigation of the Relationship Between Extramural Vascular Invasion (EMVI) and CpG Island Methylator Phenotype (CIMP) in Rectal Cancer

Colorectal cancer (CRC) is the third most frequent cancer and the second leading cause of cancer death worldwide. Each year, one million people will develop CRC, and 40-50% will die within five years. Furthermore, rectal and distal sigmoid cancers are known to present at a later stage and have a poorer prognosis than other colonic cancers. Rectal cancers that demonstrate pathological extramural vascular invasion (EMVI-positive) are known to have a poorer prognosis than those that do not (EMIV-negative), and EMVI has is acknowledged as an important risk factor for systemic recurrence, local recurrence and death. Additionally, EMVI status influences the need for pre- and post-operative chemoradiation (CRT); which may influence survival outcomes. Aberrant DNA methylation is emerging as a carcinogenic mechanism and potential biomarker in colorectal cancer. This study investigates the association between hypermethylation and EMVI in vivo and in vitro. Firstly, the in vivo associations between hypermethylation, EMVI, and clinical and histopathological outcomes are examined. Secondly, an investigation of the effects of demethylation on invasive colorectal cell lines in vitro aims to illuminate the genetic and cellular mechanisms that underlie methylation-dependent pathological cellular behaviour. Finally, highlighted biologic mechanisms are investigated in vivo to discover if there is an association with EMVI and survival outcomes. By these means the axis of association between hypermethylation, EMVI, and clinical outcomes is investigated. The investigation is conducted within the framework of consensus molecular subtyping in colorectal cancer, and in concordance with current methodologies of assessing DNA methylation status. The primary findings demonstrate that EMVI is associated with hypermethylation in vivo, but that there is no direct correlation between hypermethylation and disease-free (DFS) or overall survival (OS). In vitro, demethylation of hypermethylated colorectal cancer cells, by means of established demethylating agent 5-azacytidine and putative demethylator RRx-001, reduces their propensity to migrate and invade. Demethylation in vitro is also associated with changes in the expression of the metalloproteinases involved in the metabolism of the basement membrane and the epithelial-to-mesenchymal transition and tumour metastasis, notably MMP2 and TIMP2. Changes in expression were confirmed at transcriptomal and proteomic levels in response to demethylation. In vivo, MMP2 expression was shown to be statistically significantly associated with EMVI, DFS, and OS, and was also independently predictive of EMVI, raising the possibility that it could act as a diagnostic and predictive biomarker in rectal cancers. These findings indicate a mechanistic association between hypermethylation and EMVI, mediated by methylation-dependent expression of metalloproteinases. Metalloproteinase expression, specifically MMP2, may act as a potential biomarker for EMVI and correlates to survival outcomes in rectal cancer

Report of the Secretary of the Interior, being part of the message and documents communicated to the two Houses of Congress at the beginning of the second session of the Fiftieth Congress : Annual Report of the Commissioner of Indian Affairs, 1888

Annual Message to Congress with Documents; Pres. Cleveland. 3 Dec. HED 1, 50-2, v1-16. 14426p. [2626-2633] Indian management; railroads through reservations; Apaches held as prisoners; allotments of land in severalty; education; reduction of the Sioux reservation; annual report of the Sec. of War (Serials 2628-2633); annual report of the Sec. of Interior (Serials 2636-2641); annual report of the Gen. Land Office (Serial 2636); annual report of the CIA (Serial 2637); etc

OGO program summary

An overview of the OGO program is presented. Brief descriptions of the six OGO spacecraft, and the experiments on each are included