Phosphorylation of CENP-A on serine 7 does not control centromere function

CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic centromeres via its CENP-A targeting domain and either one of its terminal regions. In humans, several post-translational modifications occur on CENP-A, but their role in centromere function remains controversial. One of these modifications of CENP-A, phosphorylation on serine 7, has been proposed to control centromere assembly and function. Here, using gene targeting at both endogenous CENP-A alleles and gene replacement in human cells, we demonstrate that a CENP-A variant that cannot be phosphorylated at serine 7 maintains correct CENP-C recruitment, faithful chromosome segregation and long-term cell viability. Thus, we conclude that phosphorylation of CENP-A on serine 7 is dispensable to maintain correct centromere dynamics and function

Deaf Catholic Newsletter, Spring 2018

A newsletter published for Deaf Catholics in Philadelphia, P

Regina grahamii

Number of pages=40Geological SciencesIntegrative Biolog

The Bulletin: Sidney Kimmel Medical College at Thomas Jefferson University, Volume 67, Issue 1, Winter 2018

This issue includes: Dean\u27s Column Findings: Living Electrodes may change neurological device design Ch-ch-ch-changes: Jefferson\u27s realignment of departments and programs The Difference Alumni Make: A message from Elizabeth Dale A Fighting Chance: Harrisburg\u27s boxing scene has an unlikely ally in cardiologist Andrew Foy, MD \u2708 Alumni Weekend 2017 Jefferson Gala: Gathering to celebrate our shared success Time Capsule The Shot Doc: Meet Herb Magee, head coach of Jefferson\u27s men\u27s basketball team, the Rams Going the Distance: Students bring compassion into the clinic in Nicaragua\u27s remote mountains On Campus Stephanie Moleski, MD \u2705: Jefferson doctor moves from board room to exam room Class Notes In Memoriam By the Number

Republican Monsters: The Cultural Construction of American Positivist Criminology, 1767-1920

This dissertation examines the history of and cultural influences on positivist criminology in the United States. From Benjamin Rush to the present day, the U.S. has produced an extensive corpus of empirical and theoretical studies that seeks to discern an objective, scientifically-grounded basis for criminal behavior. American positivist criminology has drawn on numerous subfields and theories, including rational choice / economic theory, biology, and psychology, but in all cases, maintains that a purely scientific explanation of offending is possible. This study proceeds from the perspective that divisions between scientific and non-scientific thought are untenable. Drawing on scholarship in literary criticism and sociology, I argue that positivist criminology confronts an inherent contradiction in purporting to develop a purely scientific account of phenomena that are defined by the moral and cultural sentiments of a society. I thus hypothesize that positivist criminology is in fact reliant on the irrational and fictive cultural tropes and images of crime that it claims to exorcize. The dissertation proceeds by reviewing the literature on the history of criminology, developing a set of functional types or tropes for character analysis, and then examining four separate periods in the development of scientific criminology: eighteenth century studies of rational action, nineteenth century studies of defective reasoning, early twentieth century studies of race and crime, and the development of scientifically informed criminalistics programs. Each of these cases captures a different period and focus in the development of scientific criminology. In threading continuity between these cases, I show how criminological positivism is consistently reliant on culturally informed tropes and characters to render itself sensible and coherent

The Importance of Cognitive Screening to Promote Clinical Decision-Making Skills

Description: Research has revealed decreased cognitive function to be associated with mobility deficits and increased fall risk. The role of the physical therapist as the Movement Specialist of the patient-centered team should include screening for cognitive dysfunction in an effort to promote clinical decision-making and early intervention. The presentation will discuss cognitive changes associated with aging to improve understanding of normal aging, mild and major neurocognitive disorder. The presentation will identify tools commonly used for cognitive screening and assist participants in the selection process. Participants will analyze sample screening findings necessary for clinical decision-making skills. The presentation will recognize the clinical significance for cognitive screening by the physical therapist to promote patient-centered care/management and early intervention. In conclusion, the presentation will encourage educational opportunities for early exposure of cognitive screening by Student Physical Therapists (SPT) enrolled in Doctor of Physical Therapy (DPT) programs to prepare for clinical internship or post-graduation. Participant Outcomes: Outcome 1: Understand cognitive changes associated with aging including normal aging, mild, and major neurocognitive disorder. Outcome 2: Identify tools commonly used for cognitive screening and analyze findings to promote clinical decision-making skills by the physical therapist. Outcome 3: Discuss the clinical significance for cognitive screening by the physical therapist for patient-centered care/management and early interventio

Osteological Evidence of Possible Tuberculosis from the Early Medieval Age (6th–11th Century), Northern Italy

We discuss the probable presence of tuberculosis in non-adults of a medieval rural com- munity in northern Italy with a biocultural perspective. Before birth, mother and child have a closely interconnected relationship, as suggested by the role of microchimerism on maternal health. To better understand maternal–child health and related stress factors, paleopathology has investigated the potential of this relationship in recent years. Diseases with environmental development factors such as infections depend on and are strongly affected by maternal control variables such as, for example, breastfeeding and the growth environment. This article presents ISZ2, the second possible case of childhood tuberculosis identified in northeastern Italy through recent paleopathological criteria. The subject is of primary importance as it not only represents a direct testimony of this infectious disease otherwise known only from historical sources, but also increases our knowledge on the state of health of infants in this area, which to date are scarcely analyze