Título: In primum librum Magistri Sententiarum, Disputationes grauissimae abstrusos quaestionum Theologicarum sensus enodantes

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Downregulated serum 14, 15-epoxyeicosatrienoic acid is associated with abdominal aortic calcification in patients with primary aldosteronism

Patients with primary aldosteronism (PA) have increased risk of target-organ damage, among which vascular calcification is an important indicator of cardiovascular mortality. 14, 15-Epoxyeicosatrienoic acid (14, 15-EET) has been shown to have beneficial effects in vascular remodeling. However, whether 14, 15-EET associates with vascular calcification in PA is unknown. Thus, we aimed to investigate the association between 14, 15-EET and abdominal aortic calcification (AAC) in patients with PA. Sixty-nine patients with PA and 69 controls with essential hypertension, matched for age, sex, and blood pressure, were studied. 14, 15-Dihydroxyeicosatrienoic acid (14, 15-DHET), the inactive metabolite from 14, 15-EET, was estimated to reflect serum 14, 15-EET levels. AAC was assessed by computed tomographic scanning. Compared with matched controls, the AAC prevalence was almost 1-fold higher in patients with PA (27 [39.1%] versus 14 [20.3%]; P=0.023), accompanied by significantly higher serum 14, 15-DHET levels (7.18±4.98 versus 3.50±2.07 ng/mL; P<0.001). Plasma aldosterone concentration was positively associated with 14, 15-DHET (β=0.444; P<0.001). Multivariable logistic analysis revealed that lower 14, 15-DHET was an independent risk factor for AAC in PA (odds ratio, 1.371; 95% confidence interval, 1.145–1.640; P<0.001), especially in young patients with mild hypertension and normal body mass index. In conclusion, PA patients exibited more severe AAC, accompanied by higher serum 14, 15-DHET levels. On the contrary, decreased 14, 15-EET was significantly associated with AAC prevalence in PA patients, especially in those at low cardiovascular risk

Dilucidationum et declamationum tropologicarum in Esaiam prophetam libri quindecim : tomis tribus diuisi...: tomus primus

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Dilucidationum et declamationum tropologicarum in Esaiam prophetam libri quindecim : tomis tribus diuisi...: tomus tertius

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Two Step Filament Eruption During 14-15 March 2015

We present here an interesting two-step filament eruption during 14-15 March 2015. The filament was located in NOAA AR 12297 and associated with a halo Coronal Mass Ejection (CME). We use observations from the Atmospheric Imaging Assembly (AIA) and Heliospheric Magnetic Imager (HMI) instruments onboard the Solar Dynamics Observatory (SDO), and from the Solar and Heliospheric Observatory (SOHO) Large Angle and Spectrometric Coronagraph (LASCO). We also use H-alpha data from the Global Oscillation Network Group (GONG) telescope and the Kanzelhoehe Solar Observatory. The filament shows a first step eruption on 14 March 2015 and it stops its rise at a projected altitude ~ 125 Mm on the solar disk. It remains at this height for ~ 12 hrs. Finally it eruptes on 15 March 2015 and produced a halo CME. We also find jet activity in the active region during both days, which could help the filament de-stabilization and eruption. The decay index is calculated to understand this two-step eruption. The eruption could be due to the presence of successive instability-stability-instability zones as the filament is rising.Comment: 11 pages, 7 figures, accepted for the publication in Solar Physic