With large amounts of nanotoxicology studies delivering contradicting results and a complex, moving
regulatory framework, potential risks surrounding nanotechnology appear complex and confusing. Many
researchers and workers in different sectors are dealing with nanomaterials on a day-to-day basis, and have a
requirement to define their assessment/management needs. This paper describes an industry-tailored
strategy for risk assessment of nanomaterials and nano-enabled products, which builds on recent research
outcomes. The approach focuses on the creation of a risk profile for a given nanomaterial (e.g., determine
which materials and/or process operation pose greater risk, where these risks occur in the lifecycle, and the
impact of these risks on society), using state-of-the-art safety assessment approaches/tools (ECETOC TRA,
Stoffenmanager Nano and ISO/TS 12901-2:2014). The developed nanosafety strategy takes into account
cross-sectoral industrial needs and includes (i) Information Gathering: Identification of nanomaterials and
hazards by a demand-driven questionnaire and on-site company visits in the context of human and
ecosystem exposures, considering all companies/parties/downstream users involved along the value chain;
(ii) Hazard Assessment: Collection of all relevant and available information on the intrinsic properties of the
substance (e.g., peerreviewed (eco)toxicological data, material safety data sheets), as well as identification of
actual recommendations and benchmark limits for the different nano-objects in the scope of this projects;
(iii) Exposure Assessment: Definition of industry-specific and application-specific exposure scenarios taking
into account operational conditions and risk management measures; (iv) Risk Characterisation: Classification
of the risk potential by making use of exposure estimation models (i.e., comparing estimated exposure
levels with threshold levels); (v) Refined Risk Characterisation and Exposure Monitoring: Selection of
individual exposure scenarios for exposure monitoring following the OECD Harmonized Tiered Approach
to refine risk assessment; (vi) Risk Mitigation Strategies: Development of risk mitigation actions focusing on
risk prevention.This work was supported by ongoing
projects that received funding
from the European Union’s Horizon
2020 research and innovation programme
under grant agreement no
646155 (INSPIRED), grant agreement
no 646296 (Hi-Response)
and grant agreement no 691095
(NANOGENTOOLS)
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