Stereodivergent Total Syntheses of Chaetominine-Type Alkaloids, Radical Cascade Cyclization for the Syntheses of Imidazo-Fused Heteroaromatics and the Syntheses of the Analogs of 2-Carboxyl-6-HydroxyOctahydroIndole Unit

Abstract

含氮化合物存在于大部分的天然产物和药物分子中，对于含氮化合物的全合成以及方法学研究一直是有机化学的研究热点。本论文对氮杂环化合物全合成以及合成方法学进行了研究。 发展了一种立体多样性不对称合成(-)-aniquinazolineD推测结构、(-)-isochaetominineC和(+)-14-epi-isochaetominineC的策略，并利用此策略用于完成所有8个2，3位顺式的(-)-isochaetominineC立体异构体，(-)-isochaetomininesA、B和(-)-isochaetominine推测结构的全合成。通过全合成研究，天然(-)-pseudofischeri...The nitrogen-containing compounds are important as natural products and pharmaceuticals and the development of efficient methods for their preparation is highly desriable. First, a stereodivergent and enatioselective method has been developed for the total syntheses of chaetominine-type alkaloids including the proposed structures of (-)-pseudofischerine, (-)-aniquinazoline D and (-)-isochaetomini...学位：理学博士院系专业：化学化工学院_有机化学学号：2052012015354