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Additional file 5: of Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

By Tong Liu (107783), Xin Zhang (35492), Lutao Du (332082), Yunshan Wang (286067), Xiaoming Liu (47653), Hui Tian (322212), Lili Wang (104605), Peilong Li (755143), Yinghui Zhao (5803646), Weili Duan (781336), Yujiao Xie (2745448), Zhaowei Sun (6486410) and Chuanxin Wang (332087)

Abstract

Figure S2. related to Fig. 2. miR-128-3p expression in CRC cell lines and its effect on oxaliplatin resistance. A. Migration and invasion ability of HT29OxR cells transfected with Lv-128 and Ctrl were assessed with a Transwell assay. B. Motility ability of HT29OxR cells transfected with Lv-128 and Ctrl were assessed by wound healing assays. C. Accumulation of Pt in HT29OxR cells transfected with Lv-128 or Ctrl following exposure to 30 μM oxaliplatin treatment for 24 h. D. Total Pt-DNA adduct levels in HT29OxR cells transfected with Lv-128 or Ctrl following exposure to 30 μM oxaliplatin treatment for 24 h. E. The immunofluorescence analysis of nuclear foci for γ-H2AX expression induced by oxaliplatin in HT29OxR cells transfected with Lv-128 or Ctrl after 24 h` oxaliplatin exposure (30 μM). Scale bars, 10 μm. F. RT-qPCR assay was performed to detect the miR-128-3p expression in FHC cells transfected with Lv-128 or Ctrl. (TIF 1535 kb

Topics: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, miR-218-3p, Exosome, Colorectal cancer, Chemoresistance, Epithelial-mesenchymal transition, Drug efflux
Year: 2019
DOI identifier: 10.6084/m9.figshare.7867100.v1
OAI identifier: oai:figshare.com:article/7867100
Provided by: FigShare
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