Polycaprolactone
(PCL) was reported a long time ago; however, its
biomedical applications has not been extensively investigated in comparison
with poly(lactide-<i>co</i>-glycolide) (PLGA) due to its
too slow degradation profile. Here, we are reporting an oxalate-connected
oligocaprolactone multiblock copolymer (PCL-OX) as a fast degradable
PCL while maintaining its crystalline properties and low melting point
of PCL. The in vivo application of the paclitaxel-loaded PCL-OX microspheres
provided a steady plasma drug concentration of 6–9 μg/mL
over 28 days, similar to that of the PLGA microspheres. Both PCL and
PLGA microspheres were completely cleared two months after in vivo
implantation. The PCL-OX microspheres showed a similar tissue compatibility
to that of PLGA microspheres in the subcutaneous layer of rats. These
findings suggest that PCL-OX is a useful biomaterial that solves the
slow degradation problems of PCL and, thus, may find uses in other
biomedical applications as an alternative to PLGA
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.