Synthesis and antibacterial evaluation of nitrogen containing novel heterocyclic chalcones

Abstract

<p>Thirteen different novel heterocyclic chalcones were synthesized using cycloaddition and Claisen–Schmidt condensation reactions. These newly synthesized compounds were characterized by their spectral studies and structure of (<i>E</i>)-3-(4-methoxyphenyl)-1-(5-methyl-1-(pyridin-3-yl)-1<i>H</i>-1,2,3-triazol-4-yl)prop-2-en-1-one (<b>4h</b>) was also evidenced by single crystal X-ray studies. These compounds were evaluated for antibacterial activities against seven bacterial strains <i>in vitro</i>. Compounds <b>4b</b> and <b>4c</b> containing 4-fluoro and 4-chloro groups have shown remarkable inhibition as showed by the standard drug ciprofloxacin against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, respectively. Another compound <b>4k</b> containing 3,4,5-trimethoxy group also showed similar activity against both these strains. Beside these three potential compounds <b>4b, 4c, 4k</b>, one more compound <b>4g</b> containing 4-methyl group showed equivalent inhibition as that of standard drug against <i>E. coli.</i> These categories of compounds are therefore good candidates for developing new effective antibacterial in future.</p