Diastereoselective Control Through Hydrogen Bonding in the Aziridination of the Chiral Allylic Alcohols by Acetoxyaminoquinazolinone
Abstract
A high diastereoselectivity (up to >99:1) is found for the aziridinations of chiral allylic alcohols with acetoxyaminoquinazolinone (Q-NHOAc). The selectivity is explained in terms of hydrogen bonding between the hydroxy functionality of the allylic alcohol and the remote carbonyl group of the quinazolinone- Dataset
- Dataset
- Biochemistry
- Cell Biology
- Genetics
- Pharmacology
- Biotechnology
- Evolutionary Biology
- Immunology
- Cancer
- Mental Health
- Chemical Sciences not elsewhere classified
- quinazolinone
- diastereoselectivity
- selectivity
- Chiral Allylic Alcohols
- AcetoxyaminoquinazolinoneA
- Aziridination
- Diastereoselective Control
- Hydrogen Bonding
- aziridination
- term
- carbonyl group
- allylic alcohol
- hydroxy functionality
- acetoxyaminoquinazolinone
- chiral allylic alcohols
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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