Rhodium-Catalyzed Enantioselective 1,6-Addition of Arylboronic Acids to Enynamides: Asymmetric Synthesis of Axially Chiral Allenylsilanes

Abstract

Rhodium-catalyzed asymmetric 1,6-addition of arylboronic acids to β-alkynyl acrylamides substituted with a silyl group on the alkyne terminus took place to give high yields of axially chiral allenylsilanes with 94−99% enantioselectivity, which was realized by use of a rhodium/chiral diene complex