Ethylene in Organic Synthesis: A New Route to Anticholenergic Pyrrolidinoindolines, and Other Molecules with All Carbon-Quaternary Centers via Asymmetric Hydrovinylation
Abstract
The asymmetric hydrovinylation (1 mol % Ni-cat., 1 atm, ethylene, >98% ee) products from 1-methylenetetralines are readily converted into 3,3-disubstituted oxindoles and subsequently to pyrrolidinoindolines. These hydrovinylation products are also useful for the syntheses of enantiopure benzomorphans- Dataset
- Dataset
- Biochemistry
- Microbiology
- Pharmacology
- Biotechnology
- Ecology
- Sociology
- Immunology
- Developmental Biology
- Plant Biology
- Environmental Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Ethylene
- ee
- Organic Synthesis
- Other Molecules
- pyrrolidinoindoline
- Asymmetric HydrovinylationThe
- ethylene
- Center
- oxindole
- hydrovinylation products
- mol
- methylenetetraline
- disubstituted
- New Route
- Anticholenergic Pyrrolidinoindolines
- synthese
- enantiopure benzomorphans
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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