Schematic representation of PRDM9 domains and allelic variation in <i>Pan</i>.

Abstract

<p>The top block depicts alleles identified in this study. The second block shows the additional alleles characterized by Auton et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039064#pone.0039064-Auton1" target="_blank">[36]</a>. The four alleles common to both studies are shown in the top block, with the number of occurrences and the corresponding (sub-)species given in square brackets. Pp  =  <i>Pan paniscus,</i> Ptv  =  <i>P. troglodytes verus</i>, Ptt  =  <i>P. t. troglodytes</i>, Pts  =  <i>P. t. schweinfurthii</i>. Different ZnF repeats are coded by letters and repeats marked with a * differ from those with the same letter code by one, two, or three synonymous substitutions. The underlying nucleotide sequence, as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039064#pone-0039064-g002" target="_blank">Figure 2</a>, of O* is n or zg, D* represents q, A* is zf and U* represents w. Colors correspond to the AA residue combination at positions −1, 3 and 6 of the ZnFs, as given in the legend. Residue position 2, which also plays a role in DNA binding is fixed (serine) and therefore not shown. Human allele A is depicted for reference.</p