Modafinil treatment prevents METH-induced increase of pro-apoptotic and decrease of anti-apoptotic markers in the striatum.

Abstract

<p>Expression of pro-apoptotic BAX (A) and anti-apoptotic Bcl2 (B) proteins in the striatum, measured by Western blot analyses. Striata were obtained 16 hours after VEH, MOD, METH or M+M treatments (n = 5−9).Values represent mean ± SEM (% of control). One-way ANOVA followed by Fisher’s LSD. different letters: p<0.05.</p