Model of the structure of MSPβ/RON Sema complex.

Abstract

<p>Arg689 and the location of the α/β cleavage site are highlighted in magenta color. The molecular surfaces are shown in transparent colors. The model was built by super positioning the crystal structures of MSPβ <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027269#pone.0027269-Carafoli1" target="_blank">[22]</a> (PDB entry 1ASU) and RON-Sema-PSI (Chao and Herzberg, unpublished) on the crystal structure of the HGFβ/MET-Sema-PSI complex <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027269#pone.0027269-Stamos1" target="_blank">[29]</a> (PDB entry 1SHY). In this model, Arg689 is not directly involved in the RON/MSP interface.</p