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Glucose tolerance in leptin-treated MKR mice with or without hepatic vagotomy.

By Xiaosong Li (135207), Xhiping Wu (355986), Raul Camacho (355987), Gary J. Schwartz (179665) and Derek LeRoith (135221)

Abstract

<p>Selective hepatic branch vagotomy (VGX) partially reversed the ability of two week third intracerebroventricular leptin treatment to improve glucose tolerance in male MKR mice, relative to artificial cerebrospinal fluid (ACSF) vehicle treated controls. SHAM  =  sham surgical treatment. A. Intraperitoneal glucose tolerance (ipGTT, 2 g/kg), * p<0.05, B. Area under the curve (AUC) during ipGTT. All data presented as means ± SEM, N = 6–7/group. Different superscript letters indicate significant differences at p< 0.05. * p<0.05.</p

Topics: Molecular Biology, Chemistry, leptin-treated, mkr, mice, hepatic
Year: 2013
DOI identifier: 10.1371/journal.pone.0017058.g006
OAI identifier: oai:figshare.com:article/468603
Provided by: FigShare
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