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Lower level of aquaporin-4 (AQP4) immunoreactivity in the LBP-treated I/R retina.

By Suk-Yee Li (329321), Di Yang (126672), Chung-Man Yeung (329323), Wing-Yan Yu (357063), Raymond Chuen-Chung Chang (302180), Kwok-Fai So (143423), David Wong (189814) and Amy C. Y. Lo (329326)

Abstract

<p>(A–C) Photomicrographs taken with a 40x objective. (D–F) Photomicrographs taken with a 60x objective. In the non-ischemic control retina, mild AQP4 immunoreactivity was observed in the astrocytic end-feet in ILM and perivascular regions near INL (A & D). However, intense AQP4 immunoreactivity was seen in the astrocytic end-feet in ILM and perivascular regions of the vehicle-treated I/R retina (B & E). However, the AQP4 immunoreactivity in LBP-treated I/R retina was comparable with that in the non-ischemic control retina (C & F). Results were further confirmed by the semi-quantitative analysis (G). <sup>##</sup>p<0.01 vs. non-ischemic control retina, *p<0.05 vs. vehicle-treated I/R retina. Scale bar for A–C, 25 µm. Scale bar for D–F, 15 µm.</p

Topics: Medicine, Neuroscience, aquaporin-4, immunoreactivity, lbp-treated
Year: 2013
DOI identifier: 10.1371/journal.pone.0016380.g005
OAI identifier: oai:figshare.com:article/474645
Provided by: FigShare
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