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Delivery of S14G-HN to brain by intranasal administration.

By Takako Niikura (357548), Elkhansa Sidahmed (357550), Chiho Hirata-Fukae (357552), Paul S. Aisen (182509) and Yasuji Matsuoka (259420)


<p>3xTg-AD mice (13 month-old) were intranasally administrated with S14G-HN (B) or vehicle (A), and sacrificed after 1 hour of administration. Brains were fixed with 4% paraformaldehyde and 30 µm sagittal sections of brains were subjected to immunostaining using anti-HN antibody (P04) and biotin-conjugated secondary antibody followed by visualization with avidin-fluorescein. ACB, Nucleus accumbens; AON, Anterior olfactory nucleus; NBD, Diagnal band nucleus; OT, Olfactory tubercle; SI, Substantia innominata. Bar = 500 µm.</p

Topics: Cell Biology, Neuroscience, s14g-hn, intranasal
Year: 2013
DOI identifier: 10.1371/journal.pone.0016259.g001
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Provided by: FigShare
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