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Scheme of activation of the therapeutic molecule in cells infected with HCV.

By Xiaoyu Wen (357980), Takayuki Abe (170440), Hiroshi Kukihara (357981), Shuhei Taguwa (357982), Yoshio Mori (357983), Hideki Tani (357985), Nobuyuki Kato (235685), Tetsuro Suzuki (180340), Masashi Tatsumi (357988), Kohji Moriishi (299985) and Yoshiharu Matsuura (357989)


<p>The chimeric molecules are cleaved by HCV NS3/4A protease and the released fragments inhibit propagation of HCV through induction of IFN after translocation into the nucleus (cIRF7) or disruption of the replication complex (cVAP-C), whereas the molecule is stably anchored in the ER within uninfected cells.</p

Topics: Chemistry, Infectious Diseases, Virology, activation, therapeutic, cells, infected
Year: 2013
DOI identifier: 10.1371/journal.pone.0015967.g003
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Provided by: FigShare
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