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Sphingolipid levels in the livers of DIO mice after treatment with Genz-112638.

By Nelson S. Yew (363847), Hongmei Zhao (250090), Eun-Gyoung Hong (363850), I-Huan Wu (363852), Malgorzata Przybylska (363854), Craig Siegel (363855), James A. Shayman (359510), Cynthia M. Arbeeny (363856), Jason K. Kim (188089), Canwen Jiang (363857) and Seng H. Cheng (142952)

Abstract

<p>C57BL/6 mice were fed a normal diet (Lean) or a HFD (DIO) for 8 weeks. The DIO mice were then treated with Genz-112638 or placebo (water) by twice daily oral gavage (120 mg/kg/day) for 22 weeks, while remaining on the HFD. Sphingolipid levels were determined by high performance liquid chromatography – tandem mass spectrometry (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011239#s4" target="_blank">Materials and Methods</a>). Data shown as mean ± SEM (n = 6–9 mice per group). *<i>P</i><0.05, **<i>P</i><0.01 Genz-112638 DIO vs. Water DIO.</p

Topics: Chemistry, Virology, Computational Biology, levels, livers, dio, mice
Year: 2013
DOI identifier: 10.1371/journal.pone.0011239.g001
OAI identifier: oai:figshare.com:article/514012
Provided by: FigShare
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