Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization
Abstract
The first asymmetric total synthesis of (−)-hippodamine has been accomplished via the concise construction of its azaphenalene core, which is featured by the 2,4,6-chiral piperidine synthesis based on one-pot asymmetric azaelectrocyclization in the partially activated substituent system and the subsequent intramolecular Mannich reaction- Text
- Journal contribution
- Biochemistry
- Biotechnology
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- azaelectrocyclization
- hippodamine
- azaphenalene core
- Extended
- Asymmetric
- intramolecular Mannich reaction
- AzaelectrocyclizationThe
- synthesis
- substituent system
- construction
- chiral
- Stereocontrolled Construction
- piperidine
- Total Synthesis
- Azaphenalene Skeleton
- Hippodamine
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This paper was published in FigShare.
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