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Cobalt-Catalyzed Enantioselective Intramolecular Hydroacylation of Ketones and Olefins

By Junfeng Yang (1590952) and Naohiko Yoshikai (1479319)


Cobalt–chiral diphoshine catalytic systems promote intramolecular hydroacylation reactions of 2-acylbenzaldehydes and 2-alkenylbenzaldehydes to afford phthalide and indanone derivatives, respectively, in moderate to good yields with high enantioselectivities. The ketone hydroacylation did not exhibit a significant H/D kinetic isotope effect (KIE) with respect to the aldehyde C–H bond, indicating that C–H activation would not be involved in the rate-limiting step

Topics: Biochemistry, Biotechnology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, exhibit, Enantioselective, alkenylbenzaldehyde, phthalide, indanone derivatives, acylbenzaldehyde, aldehyde, enantioselectivitie, activation, ketone hydroacylation, Ketone, Hydroacylation, OlefinsCobalt, isotope effect, intramolecular hydroacylation reactions, yield, Intramolecular, bond, KIE, diphoshine
Year: 2014
DOI identifier: 10.1021/ja509919x.s001
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Provided by: FigShare
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