Schematic representation of the contribution of SslE to <i>E.coli</i> pathogenesis.
<p>Gut mucus forms two layers, an inner firm mucus layer devoid of bacteria, and an outer layer that is not sterile and is a major habitat for commensal bacteria. <i>E. coli</i> can penetrate this barrier through the SslE-mediated enzymatic degradation of the mucus, targeting epithelial cells. This interaction will eventually lead to IL-8 release and neutrophils recruitment.</p
Biological Sciences, coli access, mucosal barrier, target cells, Pathogenic E, neutrophil recruitment, growth rate postulating, colonization factor favouring E, Host Cells SslE, mucin substrates, mucus favouring bacteria adhesion, il, Host cells, coli Exploits SslE Mucinase Activity, SslE expression, coli penetration, vaccine candidate, coli fitness
DOI identifier: 10.1371/journal.pone.0117486.g007
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