The effects of silencing Pik3ip1 on the PI3K/AKT/mTOR pathway.
<p>NRCMs were transfected with the indicated siRNA for 24 h and subsequently serum-starved for 24 h. <b>(A)</b> PI3K activity (p110α) in the siNegative and siPik3ip1-transfected NRCMs. Western blot analyses of samples from siNegative and siPik3ip1-transfected NRCMs were performed after 48 h. (<b>B–E</b>) Representative immunoblot images of phosphorylated protein and total protein (upper), and the ratio of phosphorylated protein/total protein (bottom) for (<b>B</b>) AKT, (<b>C</b>) mTOR, (<b>D</b>) p70s6k, and (<b>E</b>) eEF2. <b>(F)</b> ERK 1/2 (n = 3, * p < 0.05 and ** p < 0.01, t test)</p
Uncategorised, pah, Inhibiting PI 3K Pathway Cardiac hypertrophy, Pik 3ip shares homology, Pik 3ip deficiency, p 110a subunit, phh, PI 3K activity, Pik 3ip Modulates Cardiac Hypertrophy, Pik 3ip attenuated PI 3K, PI 3K kinase B, nrcm, Pik 3ip, akt, PI 3K
DOI identifier: 10.1371/journal.pone.0122251.g003
Sorry, we are unable to provide the full text but you may find it at the