DNA cleavage activities of two dinuclear copper coordination polymers

Abstract

<div><p>The DNA cleavage activities of two coordination polymers of Robson-type macrocycles, {[Cu₄L¹(4,4′-bipy)₂](ClO₄)₄·H₂O}_∞ (<b>1</b>) and {[Cu₄L²(4,4′-bipy)₄](ClO₄)₄·2CH₃CN·2H₂O}_∞ (<b>2</b>) (where H₂L¹ and H₂L² are the [2 + 2] condensation products of 1,3-diaminopropane with 2,6-diformyl-4-methylphenol and 2,6-diformyl-4-fluorophenol, respectively), have been studied. The interactions of the complexes with calf thymus-DNA were investigated by UV–vis spectroscopy, CD spectroscopy, and gel electrophoresis. The binding constants of <b>1</b> and <b>2</b> are 7.2 × 10⁴ and 2.1 × 10⁵ M⁻¹, respectively. The complexes exhibit DNA cleavage activity, with the cleavage process involving oxidative cleavage of DNA.</p></div