Synthesis and antifungal activity evaluation of new heterocycle containing amide derivatives

Abstract

<div><p>A series of heterocycle containing amide derivatives (<b>1</b>–<b>28</b>) were synthesised by the combination of acyl chlorides (<b>1a</b>, <b>2a</b>) and heterocyclic/homocyclic ring containing amines, and their <i>in vitro</i> antifungal activity was evaluated against five plant pathogenic fungi, namely <i>Gibberella zeae</i>, <i>Helminthosporium maydis</i>, <i>Rhizoctonia solani</i>, <i>Botrytis cinerea</i> and <i>Sclerotinia sclerotiorum</i>. Results of antifungal activity analysis indicated that some of the products showed good to excellent antifungal activity, as compound <b>2</b> showed excellent activity against <i>G. zeae</i> and <i>R. solani</i> and potent activity against <i>H. maydi, B. cinerea</i> and <i>S. sclerotiorum</i>, and compounds <b>1</b>, <b>8</b> and <b>10</b> also displayed excellent antifungal potential against <i>H. maydi</i>, <i>B. cinerea</i> and <i>S. sclerotiorum</i> and good activity against <i>R. solani</i> when compared with the standard carbendazim.</p></div