Short eight-steps total synthesis of racemic asteriscunolide C
Abstract
<p>A concise total synthesis of racemic asteriscunolide C in eight steps has been described starting from neopentane diol involving an efficient Yamaguchi esterification using an aldehyde-acid, intramolecular Horner–Wittig–Emmons olefination, and a late stage ring-closing metathesis to construct the strained 11-membered ring with one <i>Z</i>- and two <i>E</i>-double bonds.</p- Text
- Journal contribution
- Biophysics
- Biochemistry
- Microbiology
- Cell Biology
- Genetics
- Molecular Biology
- Neuroscience
- Physiology
- Pharmacology
- Biotechnology
- Evolutionary Biology
- Immunology
- Plant Biology
- Chemical Sciences not elsewhere classified
- Physical Sciences not elsewhere classified
- Asteriscunolides
- Horner–Wittig–Emmons
- macrolide
- racemic synthesis
- ring-closing metathesis