Short eight-steps total synthesis of racemic asteriscunolide C

Abstract

<p>A concise total synthesis of racemic asteriscunolide C in eight steps has been described starting from neopentane diol involving an efficient Yamaguchi esterification using an aldehyde-acid, intramolecular Horner–Wittig–Emmons olefination, and a late stage ring-closing metathesis to construct the strained 11-membered ring with one <i>Z</i>- and two <i>E</i>-double bonds.</p