Incidence of Cefixime Resistance in Patients with Chronic Kidney Disease at Harapan Keluarga Hospital

Antibiotic resistance is an increasing global health challenge, especially in patients with advanced chronic kidney disease (CKD). This study aims to investigate cefixime resistance in patients with stage 4-5 CKD at Harapan Keluarga Hospital with a retrospective cohort design using medical record data. Chi-squared test analysis showed a significant association between cefixime resistance and advanced CKD (χ² = 34.714, p = 0.003). The results showed a higher prevalence of cefixime resistance in male patients (60%), antibiotic use of more than 14 days (65%), and hospitalization of more than five days (80%). The mechanism of resistance involves beta-lactamase production and changes in the gut microbiota due to dysbiosis. Factors such as irrational antibiotic use, length of hospital stay, and catheter use contributed to higher resistance. This study highlights the need for evidence-based antibiotic stewardship strategies to reduce resistance, especially in vulnerable populations such as patients with advanced CKD. Scientific implications include the development of more effective infection management strategies, close monitoring of antibiotic use, dose adjustment according to CKD severity, and education of health care workers to increase awareness of antibiotic resistance. This study contributes to efforts to prevent antibiotic resistance in the advanced CKD population

Biblometric Analysis of the Effect of Type II Diabetes Mellitus on Immunity

Type 2 diabetes mellitus is the inability of the body's cells to respond to insulin or so-called insulin resistance which causes hyperglycemia. The body's immune system is a complex system that functions to protect the body from various diseases and infections. This research was conducted with the aim of applying bibliometric methods using quantitative analysis to trace the development of research related to type 2 Diabetes Mellitus. This study uses a biblometric analysis method that can help researchers in studying the content of bibliography, citation analysis of each article taken from the lens database. The results of data with the keywords DM type 2, immune, and complication are not too much, only about 475 data were obtained, and after being identified and cleaned using vosviewer, data was obtained in the form of several clusters such as images

Analysis of Pteridophyta Plants Vegetation in Amporiwo Forest Area, Poso District

Another role of ferns is as a source of plasma nutfah and also has the potential as a source of food and medicine. Analysis of pteridophyta plant vegetation aims to describe the types of Pteridophyta plants in the Amporiwo forest area. The type of research used in this study is a qualitative approach. The population and samples in this study were all types of ferns found in the Amporiwo forest area. Data analysis used a google lens camera and a reference book on Identification of Ferns (Pteridophyta). The results of the study showed that there were types of ferns (pteridophyta) with details of 5 orders, 9 families and 17 species, namely Pyrrosia lanceolata, Phymatosorus scolopendria. Pyrrosia piloselloides, Diplazium esculentu., Drynaria quercifolia, Christella leveille, Thelypteris pectiniformis, Asplenium nidus L., Nephrolepis biserrata, Pteridium esculentum, Dicranopteris linearis, Stenochlaena palustris, Dyplazium sorgonens, Ligodium palmatum, Lycopodiella cernua, Hipoderris brownie, Asplenium Polyodon. The conclusion is that the types of Pteridophyta plants in the Amporiwo forest area were found to be 5 orders, 9 families, and 17 species

The Effect of Giving Ethanol Extract of Palm Fruit (Arenga pinnata Merr.) on Morphology and Liver Function of White Rats (Rattus norvegicus L.) Induced by Carbon Tetrachloroide

Carbon tetrachloride is well known as hepatotoxic, including toxic substances commonly used to induce liver damage. Sugar palm (Arenga Pinnata Merr.) is a type of palm plant that is used as a source of antioxidants, one of which is part of the fruit. The aim of this research is to determine the effect of administering ethanol extract of palm fruit (Arenga pinnata Merr.) on the morphology and liver function of rats (Rattus norvegicus L.) which is induced by carbon tetrachloride. This research method used a completely randomized design consisting of 20 mice grouped into 5 groups, namely negative control, positive control, P1 (ethanol extract of palm fruit 90 mg/kg BW), P2 (180 mg/kg BW), P3 (360 mg /kg BW) with each group having four repetitions. Data analysis was carried out using the One Way ANOVA test and continued with the Duncan test. The results of this study show that carbon tetrachloride at a dose of 1 mL/kg BW can damage the morphological appearance of rat liver and increase SGOT and SGPT levels. Giving ethanol extract of palm fruit to the P3 group at a dose of 360 mg/kg BW was the most effective dose to improve liver morphology and reduce SGOT and SGPT levels in white rats induced by carbon tetrachloride

Effect Differences Depth on Chlorophyll Content (Kappaphycus alvarezii) Seaweed Tissue Culture Cultivated in The Waters of Gerupuk Bay

Seaweed developed through tissue culture techniques has several advantages, such as high carrageenan content, rapid growth, and resistance to disease. In seaweed cultivation, growth is influenced by photosynthetic pigments such as chlorophyll. Chlorophyll plays an important role in converting sunlight into chemical energy needed for growth. This study aims to analyze the chlorophyll content in Kappaphycus alvarezii cultivated at different depths in Gerupuk Bay waters. This study used an experimental method with a completely randomized design (CRD) consisting of 4 treatments and 3 replications, namely depths of 0 cm (P1), 5 cm (P2), 10 cm (P3), and 15 cm (P4). Results of this study indicate that planting at different depths can increase the absolute weight of K. alvarezii tissue culture ranging from 283 g to 356 g, specific growth rate between 5.72%/day to 5.91%/day, seaweed production ranging from 661 g/m2 to 832 g/m2, chlorophyll content between 5.60 mg/L to 21.89 mg/L, and phycoerythrin content between 0.027 mg/L to 0.19 mg/L. The conclusion is that the cultivation of K. alvarezii tissue culture with floating rafts at different depths can affect growth and yield. Cultivation of K. alvarezii seaweed at a depth of 0 cm using the floating raft method gave the best results, namely increasing absolute weight up to 356 g, specific growth rate up to 5.91%/day, and production up to 832 g/m2, supported by chlorophyll content of 21.89 mg/L and phycoerythrin content of 0.195 mg/L. For optimal production results, it is recommended to use a depth of 0 cm in floating raft seaweed cultivation

Validitas Media Interaktif Berbasis Model PBL Menggunakan Aplikasi Geogebra Untuk Meningkatkan Kemampuan Literasi Numerasi

Penelitian ini bertujuan mengembangkan media interaktif berbasis model pembelajaran PBL (Problem Based Learning) menggunakan aplikasi Geogebra pada materi bangun datar untuk meningkatkan kemampuan literasi numerasi siswa kelas V sekolah dasar yang valid. Penelitian ini adalah penelitian dan pengembangan dengan model ADDIE (Analyze, Design, Development, Implementation dan Evaluation). Subjek dalam penelitian ini adalah siswa kelas V UPT SPF SDN 101990 Bangun Purba. Analisis data dilakukan dengan deskriptif kuantitatif fan kualitatif mengenai kevalidan media interaktif yang diperoleh dari lembar validasi oleh para ahli. Hasil penelitian menunjukkan bahwa media interaktif berbasis model PBL menggunakan aplikasi Geogebra untuk meningkatkan kemampuan literasi numerasi yang dikembangkan adalah media interaktif yang valid dengan skor validasi yakni (1) ahli bahasa sebesar 84% dengan kriteria valid, (2) ahli materi sebesar 82% dengan kriteria valid dan (3) ahli media sebesar 83% dengan kriteria valid. Dengan demikian, dapat dikatakan bahwa media interaktif berbasis model PBL menggunakan aplikasi Geogebra valid untuk meningkatkan kemampuan literasi numerasi berdasarkan hasil skor validasi yang diberikan oleh para ahli

Analisis Efektivitas Pemanfaatan Laboratorium Kimia di Sekolah Menengah Atas Negeri di Kabupaten Lombok Timur

This study aims to determine the effectiveness of using chemical laboratory functions and tools in Public Senior High Schools throughout East Lombok Regency. The approach in this study uses a descriptive quantitative approach. The population of this study consisted of all high schools in East Lombok Regency. The sample for this study comprised six schools: SMAN 2 Selong, SMAN 3 Selong, SMAN 1 Terara, SMAN 1 Pringgabaya, SMAN 1 Sembalun, and SMAN 1 Labuhan Haji, which were selected using purposive sampling.  Data collection used questionnaires and interviews; the questionnaire used was closed with a Likert scale. For the interpretation of problem data using the criteria of 5 categories (not effective, less effective, moderately effective, effective, very effective) which are determined by simple percentages and tables. Based on data analysis it is known that; 1) the effectiveness of the use of chemical laboratory functions in State Senior High Schools throughout East Lombok Regency has been effective (74.82%). 2) The effectiveness of the use of chemical laboratory equipment in State Senior High Schools throughout the East Lombok Regency has been effective (80.33%).Penelitian ini bertujuan untuk mengetahui efektivitas pemanfaatan fungsi dan alat laboratorium kimia di Sekolah Menengah Atas Negeri se-Kabupaten Lombok Timur. Pendekatan dalam penelitian ini menggunakan pendekatan kuantitatif deskriptif. Populasi penelitian ini adalah seluruh SMA se-Kabupaten Lombok Timur, kemudian sampel penelitian ini sebanyak enam sekolah yaitu SMAN 2 Selong, SMAN 3 Selong, SMAN 1 Terara, SMAN 1 Pringgabaya, SMAN 1 Sembalun dan SMAN 1 Labuhan Haji yang diambil secara purposive sampling. Pengumpulan data menggunakan angket dan wawancara, angket yang digunakan adalah tertutup dengan skala likert. Untuk penafsiran data masalah menggunakan kriteria sebanyak 5 kategori (tidak efektif, kurang efektif, cukup efektif, efektif, sangat efektif) yang ditentukan dengan presentase sederhana dan tabel. Berdasarkan analisis data diketahui bahwa; 1) efektivitas pemanfaatan fungsi laboratorium kimia di Sekolah Menengah Atas Negeri se-Kabupaten Lombok Timur sudah efektif (74,82%). 2) Efektivitas pemanfaatan peralatan laboratorium kimia di Sekolah Menengah Atas Negeri se-Kabupaten Lombok Timur sudah efektif (80,33%)

Analisis Sistem Antrean Layanan Teller

A bank is a financial institution that plays an important role in fulfilling and providing various financial services to customers. The increase in the number of customers and service time leads to queuing, especially at the teller section, thereby affecting waiting times. This article discusses customer queues at the teller service of Bank R in West Nusa Tenggara Province (NTB). Queues arise when service demand exceeds available capacity, causing customers to wait due to limited teller services. This study aims to analyze the optimization of the queuing system at teller services using the Multi-Channel Single-Phase queuing model. This model features multiple entry lines into the service system but only one service facility. The results show that the service intensity level () from Monday to Friday is , , , , and , respectively. Since , the steady-state condition is met. Thus, the queuing system performance can be considered optimal.Artikel ini membahas antrean nasabah pada layanan teller Bank R di Provinsi NTB (Nusa Tenggara Barat). Antrean muncul karena adanya kebutuhan layanan melebihi kapasitas yang tersedia sehingga nasabah harus menunggu akibat keterbatasan pelayanan di bagian teller. Pada penelitian ini, analisis optimalisasi sistem antrean pada layanan teller menggunakan model antrean Multi Channel Single Phase menjadi tujuannya. Model antrean ini memiliki beberapa jalur masuk ke sistem pelayanan namun hanya satu fasilitas pelayanan. Hasil penelitian menunjukkan bahwa tingkat intensitas pelayanan (rho) pada hari Senin hingga Jumat berturut-turut adalah 0.97, 0.98, 0.97, 0.70, dan 0.92. Karena rho<1, kondisi steady state terpenuhi. Dengan demikian, kinerja sistem antrean dapat dianggap optimal

Optimization of Volume and Mass of Eggshell in Removal of Linear Alkylbenzene Sulfonate Levels in Laundry Waste

Linear alkylbenzene sulfonate (LAS) is one of the most common anionic surfactants in synthetic detergent formulation. Being a component of domestic waste, LAS can potentially cause environmental damage. Detergent wastewater that contains LAS needs to be properly treated before being released into the environment. This study aims to treat the laundry waste by using thermally activated chicken eggshell adsorbent. The steps carried out in this study were the preparation of adsorbents, quality test of adsorbents produced, testing of adsorbent on used laundry waste based on reducing concentration of LAS and testing of the Langmuir adsorption equation and the Freundlich adsorption equation.  Adsorption process of LAS observed variations in adsorbent mass are 4g, 8g, 12 g, and 16 g, and variations in the sample volume used in this experiment are 50 ml, 100 ml, 150 ml, and 200 ml. Stirring time is 60 minutes. The filtrate was analyzed to determine the concentration of LAS.  The obtained results indicate that the optimum mass of adsorbent is 12 grams with a sample volume of 50 ml. This adsorption condition resulted in Linear Alkylbenzene Sulfonate levels of 3,376 ppm, which can reduce LAS levels by  69.86%, with an adsorption capacity of 0.2997 mg/g. Based on the result of this study, LAS adsorption follows the Langmuir isotherm equation, with a coefficient of determination (R2) greater than that of the Freundlich isotherm, which is 0.9977.  This equation indicates that the adsorption process that occurs is chemisorption. The use of thermally activated chicken eggshell as an adsorbent can be an alternative, environmentally friendly waste processing technique

Development of Scratch-Based Srikandi Media for Indonesian Cultural Heritage in Elementary School: A Preliminary Study

This research aims to develop Scratch-based learning media called SRIKANDI on IPAS material for grade IV elementary school, especially Chapter 6, "Indonesia Cultural Heritage". This media is designed to increase student motivation, engagement and understanding of the material through an interactive technology approach. The research used the Research and Development (R&D) method with a model of ADDIE (Analysis, Design, Development, Implementation, Evaluation). This research is limited only to the analysis stage. The data collection techniques are questionnaires, observations, interviews and relevant literature studies. The population in this study is SD 4 Gulang. The participants in this study were 21 fourth-grade students and teachers. Data were analyzed using descriptive analysis. The results of this study showed that the learning media used are still limited to handbooks and worksheets, and the use of interactive multimedia is only limited to PowerPoint. Hence, it is necessary to develop interactive multimedia on IPAS material, especially Indonesia’s Cultural Heritage material, that suits the needs of students to achieve learning objectives. Based on this, it can be concluded that interactive multimedia with a contextual approach needs to be developed in IPAS subjects. Based on this, it can be concluded that interactive multimedia with a contextual approach needs to be developed in IPAS subjects