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International audienceThe term "equine asthma" has been proposed as a unifying descriptor of inflammatory airway disease (IAD), recurrent airway obstruction (RAO), and summer pasture-associated obstructive airway disease. Whilst the term will increase comprehensibility for both the lay and scientific communities, its biologic relevance must be compared and contrasted to asthma in human medicine, recognizing the limited availability of peer-reviewed equine-derived data, which are largely restricted to clinical signs, measures of airway obstruction and inflammation and response to therapy. Such limitations constrain meaningful comparisons with human asthma phenotypes. Suggested minimum inclusion criteria supporting the term asthma, as well as similarities and differences between IAD, RAO, and multiple human asthma phenotypes are discussed. Furthermore, differences between phenotype and severity are described, and typical features for equine asthma subcategories are proposed. Based on shared features, we conclude that mild/moderate (IAD) and severe (RAO) equine asthma are biologically appropriate models for both allergic and non-allergic human asthma, with RAO (severe equine asthma) also being an appropriate model for late-onset asthma. With the development of new biologic treatments in humans and the application of more targeted therapeutic approaches in the horse, it would appear appropriate to further investigate the allergic (Th-2) and non-allergic (non-Th-2) phenotypes of equine asthma. Further research is required to more fully determine the potential clinical utility of phenotype classification

Bond, Stephanie

Léguillette, Renaud

Richard, Eric

Couëtil, Laurent

Lavoie, Jean-Pierre

Martin, James

Pirie, R. Scott

HAL - Normandie Université

Equine asthma: Integrative biologic relevance of a recently proposed nomenclature

HAL: Hyper Article en Ligne

Woort

Thiadens

Tinkelman

Wasko

Wenzel

Scales

Schmallenbach

Tahon

Ying

Theoharides

Wood

Crossref

The term “equine asthma” has been proposed as a unifying descriptor of Inflammatory Airway Disease (IAD), Recurrent Airway Obstruction (RAO), and Summer Pasture Associated Obstructive Airway Disease. Whilst the term will increase comprehensibility for both the lay and scientific communities, its biological relevance must be compared and contrasted to asthma in human medicine, recognizing the limited availability of peer-reviewed equine-derived data, which are largely restricted to clinical signs, measures of airway obstruction and inflammation and response to therapy. Such limitations constrain meaningful comparisons with human asthma phenotypes. Suggested minimum inclusion criteria supporting the term asthma, as well as similarities and differences between IAD, RAO and multiple human asthma phenotypes are discussed. Furthermore, differences between phenotype and severity are described, and typical features for equine asthma sub-categories are proposed. Based on shared features, we conclude that mild/moderate (IAD) and severe (RAO) equine asthma are biologically appropriate models for both allergic and non-allergic human asthma, with RAO (severe equine asthma) also being an appropriate model for late-onset asthma. With the development of new biologic treatments in humans and the application of more targeted therapeutic approaches in the horse, it would appear appropriate to further investigate the allergic (Th-2) and non-allergic (non-Th-2) phenotypes of equine asthma. Further research is required to more fully determine the potential clinical utility of phenotype classification. <br/

Bond, Stephanie R

Leguillette, Renaud

Richards, Eric

Couetil, Laurent

James, Martin

Pirie, Robert

Edinburgh Research Explorer

"Equine Asthma” – integrative biologic relevance of a recently proposed nomenclature

Archive Ouverte en Sciences de l'Information et de la Communication

https://www.pure.ed.ac.uk/ws/files/75939431/Bond_et_al_2018_Journal_of_Veterinary_Internal_Medicine.pdf

"Equine Asthma” – integrative biologic relevance of a recently proposed nomenclature

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HAL - Normandie Université

HAL: Hyper Article en Ligne

Crossref

Edinburgh Research Explorer

Archive Ouverte en Sciences de l'Information et de la Communication