Agüero-Torres

Andersen

Brandt

Brookmeyer

Buchner

Cummings

Doody

Ferri

Folstein

Gambassi

General Register Office for Scotland

Helmer

Hicks

Hötte

Inouye

ISD Scotland

Kaplan

Knopman

Landi

Larson

Lawton

Lezak

Luchsinger

Martyn

McGurn

McKhann

Mental Welfare Commission for Scotland

Mielke

Miller

Morgan

Musicco

Nelson

Newcomer

Rait

Reisberg

Richards

Robbins

Scarmeas

Schneider

Sinforiani

Solfrizzi

SPSS Inc

Starr

Stern

Thomas

Tsai

Van Dijk

Wang

Whalley

Whitmer

Wolfson

English

Tom C. Russ

G. David Batty

John M. Starr

Crossref

International Journal of Geriatric Psychiatry

Cognitive and behavioural predictors of survival in Alzheimer disease: results from a sample of treated patients in a tertiary-referral memory clinic

OBJECTIVE: This study examined the influence of cognitive and non-cognitive factors at the time of diagnosis on the survival of patients with treated probable Alzheimer Disease (AD).METHODS: Consecutive patients seen at a regional, tertiary-referral clinic completed a battery of cognitive tests and assessments of activities of daily living and neuropsychiatric symptoms. These clinic data were linked with death certificate data for all individuals and survival from diagnosis was calculated. Cox regression models were constructed using the baseline covariates.RESULTS: The sample comprised 653 patients (459 women), mean age 77.1 years (SD 7.6, range 48-94 years), diagnosed with probable AD and treated with a cholinesterase inhibitor. In the survival analysis, age was a consistently significant predictor of survival with a gender-adjusted hazard ratio of 1.35 (95% CI 1.23, 1.48) for one standard deviation increase in age. Men were at greater risk of death than women (age-adjusted HR 1.44, 95% CI 1.19, 1.73). In a model adjusted for all study variables, Paired-Associate Learning (Cambridge Automated Neuropsychological Test Assessment Battery) and the psychotic factor of the Neuropsychiatric Inventory were significant predictors of survival.CONCLUSIONS: At diagnosis, in addition to the anticipated impact of age and gender, the presence of psychotic symptoms and poor performance on paired-associate learning are also indicators of poor prognosis.</p

Russ, Tom C

Batty, G David

Starr, John M

Edinburgh Research Explorer

1 previously described in Starr

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Cognitive and behavioural predictors of survival in Alzheimer disease:results from a sample of treated patients in a tertiary-referral memory clinic

Cognitive and behavioural predictors of survival in Alzheimer disease:results from a sample of treated patients in a tertiary-referral memory clinic

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