Pulmonary fibrosis is a complex and heterogeneous disease; a more detailed and integrated understanding of the cellular and molecular mechanisms influencing its pathogenesis will aid the design of new therapies

Asangani

Atabai

Bauman

Bechtel

Belperio

Bettelli

Blackburn

Border

Bringardner

Brodlie

Burdick

Burgess

Cassel

Chan

Chen

Chiaramonte

Chilosi

Coward

Crystal

Decraene

Demedts

Denham

Dostert

Duffield

Fort

Fubini

Fulkerson

Gasse

Genovese

Hancock

Hariyawasam

Hasegawa

Hecker

Huang

Huaux

Ingram

Iredale

Jiang

Keane

Kelly

Kinder

Kisseleva

Kolb

Kolodsick

Kostadinova

Kumar

Königshoff

Lama

Langrish

Lanone

Lappalainen

Lovgren

Lupardus

Madala

Meng

Milam

Miyazaki

Moore

Murray

Nagase

Naik

Nana-Sinkam

Ortiz

Pandit

Park

Pesce

Peters-Golden

Phillips

Piguet

Prasse

Raghu

English

PubMed

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has frequently focused on the mechanisms that regulate the proliferation, activation, and differentiation of collagen-secreting myofibroblasts, recent studies have identified new pathogenic mechanisms that are critically involved in the initiation and progression of fibrosis in a variety of settings. A more detailed and integrated understanding of the cellular and molecular mechanisms of pulmonary fibrosis could help pave the way for effective therapeutics for this devastating and complex disease.</jats:p

Thomas A. Wynn

Crossref

The Journal of Experimental Medicine

Integrating mechanisms of pulmonary fibrosis

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3136685

Integrating mechanisms of pulmonary fibrosis

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