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Glycoproteomics in neurodegenerative diseases
Authors
Aarsland
Aarsland
+168Β more
Aarsland
Abdi
Aebersold
Aebersold
Aggarwal
Alexa
Anderson
Anderson
Anderson
Apweiler
Arakawa
Bahl
Borghi
Braak
Braak
Braak
Bundy
Bunkenborg
Butterfield
Castegna
Casu
Catalina
Chiang
Colangelo
Collins
Cookson
Cummings
D'Ascenzo
Dexter
Dube
Durham
El-Agnaf
Farrer
Finehout
Foltynie
Gendler
Gerber
Ghosh
Goldstein
Gulcicek
Guo
Gygi
Hagglund
Hakansson
Haltiwanger
Hanisch
Hanisch
Hann
Haqqani
Haynes
Hirabayashi
Hirotani
Hogan
Hsu
Hwang
Inatani
Irungu
Jakowec
Jankovic
Jin
Jobst
Johansen
Kaji
Kaji
Kameyama
Kamra
Kaplan
Kinjo
Kitsou
Korolainen
Krokhin
Kubota
Kuno
Kurogochi
Kussmann
Larsen
Lattard
Leverenz
Levin
Levin
Lin
Liu
Liu
Lochnit
Lowe
Lowe
Madera
Madera
Madera
Marder
Martin
Miller
Monzo
Moore
Moran
Morelle
Mormann
Nagata
Nalivaeva
Niethammer
Novogrodsky
Nussbaum
Ohtsubo
Osorio
Pan
Pan
Pan
Pan
Pan
Pisani
Qian
Rademaker
Riederer
Rite
Robertson
Roth
Rutishauser
Saez-Valero
Saez-Valero
Saez-Valero
Saez-Valero
Sasisekharan
Schrag
Sharon
Shi
Shimura
Siddique
Sihlbom
Silveyra
Simonsen
Song
Spiro
Spiro
Spiro
Srivastava
Stephens
Sudo
Sun
Suzuki
Tan
Tanaka
Thomas
Tokuda
Tumani
Varki
Verbeek
Wakabayashi
Wang
Waragai
Wenk
Wiener
Williams-Gray
Wuhrer
Xiong
Yahara
Yamashita
Yang
Yang
Yang
Yoshimi
Yuan
Yuan
Zaia
Zhang
Zhang
Zhang
Zhou
Zougman
Publication date
1 January 2010
Publisher
'Wiley'
Doi
Cite
View
on
PubMed
Abstract
Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry-based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. Β© 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79β125, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64521/1/20221_ftp.pd
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