Preparation and antioxidant activity of synthesized vanadyl （Ⅳ） trehalose and vanadyl （Ⅳ） carboxymethyl trehalose

对合成的钒氧海藻糖和钒氧羧甲基海藻糖的结构进行红外光谱分析,并利用ICP-MS测定钒的含量分别为2.9%和3.2%。同时对钒氧海藻糖和钒氧羧甲基海藻糖清除羟基自由基与DPPH自由基的能力进行研究,结果表明,钒氧海藻糖和钒氧羧甲基海藻糖清除DPPH·的能力和清除·OH的能力均比配体的清除能力有显著提高。此外,对钒氧海藻糖和钒氧羧甲基海藻糖清除羟基自由基和DPPH自由基的机理进行了讨论

UVA Assisted 4-Thiothymidine for Cancer Treatment

This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized. As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine, thus 4-thiothymidine can be readily incorporated into cellular DNA, and with the help of thymidine kinase, much more preferably into cancerous DNA. Unlike thymidine, 4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light. Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment. Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed. The various interactions between 4-thiothymidine with human serum albumin are introduced. Finally, a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given

甜罗勒提取物的抗氧化作用以及心血管疾病治疗研究

目的探讨甜罗勒提取物的抗氧化作用活性和临床心血管疾病治疗方向。方法通过甜罗勒乙醇提取物对dPPH和AbTS自由基清除能力的测定研究其抗氧化活性根据其抗氧化活性检测其治疗心血管疾病的有效性和临床应用方案。结果平行测定三次,结果表明甜罗勒70%乙醇提取物具有很好的清除dPPH自由基的作用,IC50为0.047 Mg/M l,有很好的清除AbTS自由基的作用,IC50为0.043 Mg/M l。结论甜罗勒提取物具有良好的抗氧化作用和心血管疾病治疗的研究价值

Information and Communication Technologies and Informal Scholarly Communication: A Review of the Social Oriented Research

This article reviews and analyzes findings from research on computer mediated informal scholarly communication. Ten empirical research papers, which show the effects and influences of information & communication technologies (ICTs), or the effects of social contexts on ICTs use in informal scholarly communication, were analyzed and compared. Types of ICTs covered in those studies include e-mails, collaboratories, and electronic forums. The review shows that most of the empirical studies examined the ICTs use effects or consequences. Only a few studies examined the social shaping of ICTs and ICT uses in informal scholarly communication. Based on comparisons of the empirical findings this article summarizes the ICT use effects/consequences as identified in the studies into seven categories and discusses their implications

Influence of gross saponins from tribulus terrestris L on SOD activity and MDA content for chronic high intraocular pressure in rabbit

AIM:To observe influence of gross saponins from tribulus terrestris L(GSTT)on SOD activity and MDA content for chronic high intraocular pressure in rabbit, and discusses the retina oxidative damage inhibition on chronic high intraocular pressure model of rabbit. METHODS:Totally 24 healthy New Zealand rabbits were randomly divided into 4 groups: normal control group(A group); high intraocular pressure model blank group(B group); high intraocular pressure model with GSTT treated group(C group); high intraocular pressure model with Erigeron brevicapas hand mass(EBHM)treated group(D group). High intraocular pressure model was induced by 20g/L methylcellulose injection into the anterior chamber in B group, C group and D group. D group was injected 5 mg/kg GSTT and C group was injected 4.5mg/kg EBHM and measured intraocular pressure with Schiotz tonometer every day for 4 weeks. The retina tissue superoxide dismutase(SOD)and maleic dialdehyde(MDA)content were detected 28 days later. RESULTS: After glaucoma model of rabbit eyes were established, the intraocular pressure during observation period was maintained in 32-39mmHg; High intraocular pressure model blank group and normal control group, EBHM treatment group, GSTT treatment group were compared, the differences of retina MDA, SOD content had statistical significance(P<0.05); numerical difference between EBHM treatment group and GSTT group was not statistically significant(P>0.05); EBHM treatment group, GSTT treatment group and normal control group were compared, the content of MDA in the retina was still slightly higher(P<0.05), the content of SOD slightly lower(P<0.05) CONCLUSION: GSTT can effectively improve the retina SOD activity of chronic high intraocular pressure in rabbit and reduce the content of MDA, which has a protective effect of persistent high intraocular retinal oxidative stress

FICM干预对急性运动大鼠抗氧化能力的影响

目的:探讨远红外陶瓷微珠对大鼠一次性力竭运动后血清SOD、GSH-Px、MDA含量的影响。方法:将88只雄性SD大鼠分为安静对照组(A组)、模型组(B组)、模型+热水组(C组)、(模型+陶瓷微珠组D组)。B、C、D组大鼠利用下坡跑跑台一次性运动至力竭。各组大鼠分别于安静时与运动后即刻、24h、48h、72h取心脏血,分离血清测定SOD、GSH-Px、MDA含量。结果:D组运动后各时相血清SOD、GSH-Px含量均高于B组与C组同时相(P <0. 05),D组运动后各时相血清MDA含量均低于B组与C组同时相(P <0. 05)。结论:陶瓷微珠干预手段具有抑制急性运动后机体氧自由基生成,减少过氧化损伤的作用。福建省科技厅省自然科学基金项目(2016J01404);;莆田学院育苗基金项目(2017014);莆田学院国家基金预研项目(2016076);;国家体育总局科技服务项目(2017HT008