胶原特性及其制备方法研究进展

本文阐述了胶原、明胶和胶原多肽三者的概念和不同点,介绍了胶原的结构以及Ⅰ型胶原和Ⅱ型胶原的差异,总结了胶原的七种制备方法,并对各种制备方法的优缺点进行分析,为水产动物资源制备胶原提供参考。福建省海洋生物增养殖与高值化利用重点实验室(361013);;福建省海洋生物资源开发利用协同创新中心(361013

胶体晶体生长遵从Ostwald's step rule的证实

从原子、分子的微观作用和运动预言所组成物质的宏观特性是物理力学解决问题的途径。但原子、分子太小,观察它们的运动和相互作用十分困难。胶体粒子比原子大得多,可以使用的测试手段就丰富得多,其微观信息要更容易获取。因此,胶体悬浮粒子体系提供了为研究原子体系的从时间和空间上都高度放大了的模型体系,同样可以有效地实现物理力学由微观结构到宏观行为的研究思路,这里微观单元不再是原子、分子,而是胶体粒子。用胶体粒子代替原子研究物态性质的思路早已被提出,人们发现,由胶体粒子组成的晶体体系与通常固态晶体具有很强的类比性。两者在研究相变问题(如晶体生长)上的等价性已被广泛接受。因此,胶体晶体的结果则可以被推广应用一般..

Preparation and hypoglycemic activity of selenium－enrichedasini corri colla－inulin chewable tables

以阿胶、菊粉、富硒卡拉胶等为原料,依次经过原料的干燥、混匀、制软材、干燥、过筛、压片后制得富硒阿胶-菊粉咀嚼片。本文概述了富硒阿胶-菊粉咀嚼片的制备工艺流程并对优化过程进行描述,研究了其降血糖活性功能。研究结果表明:阿胶、菊粉、富硒卡拉胶、硬脂酸镁的添加量分别为24.5%、73.5%、1%、1%,以95%的乙醇溶液为黏合剂,可制得表面光滑、色泽均匀,独特风味的富硒阿胶咀嚼片。小鼠降血糖实验结果表明,样品组小鼠在灌胃处理30 d后随机血糖有显著降低,与二甲双胍作用相当,因而该产品具有显著降低血糖水平功效。</p

Study on the rheology of xanthan and synergistic interaction with konjac gum and other gum

研究前期筛选获得一株多糖胶质高产菌Xanthomonas axonopodis所产的黄原胶FJAT-10151-DTJZ的品质,为该黄原胶的开发应用提供基础数据及参考。通过分析浓度、剪切速率、p H、加热温度、时间、冻融处理等对FJAT-10151-DTJZ粘度的影响研究其流变性,并研究其与结冷胶、黄原胶、凝胶多糖、瓜尔豆胶、刺槐豆胶、魔芋胶、果胶和壳聚糖8种胶的协效性。实验结果表明,FJAT-10151-DTJZ溶液的粘度随浓度的升高而升高,且为非牛顿流体;当FJAT-10151-DTJZ的浓度为1%时,其粘度为343 m Pa·s;p H、冻融对FJAT-10151-DTJZ的粘度影响不大;FJAT-10151-DTJZ的最佳加热温度为75℃;粘度随加热时间先增大后减小,当加热温度为75℃,加热时间为150 min,1%浓度的FJAT-10151-DTJZ溶液的粘度为808 m Pa·s。FJAT-10151-DTJZ只与魔芋胶有强烈的协同增效作用,与壳聚糖、结冷胶、黄原胶、凝胶多糖、瓜尔豆胶、刺槐豆胶、果胶无协效性。A Xanthomonas axonopodis strain producing xanthan gum had been screened,and researched the quality of xanthan gum FJAT-10151-DTJZ in order to provide basic data and reference for development and application. The rheology properties of FJAT-10151-DTJZ were discussed according to the viscosity variation with different conditions including concentration,shearing,p H,heating temperature,heating time and freezingthawing. The synergistic interactions of FJAT-10151-DTJZ with chitosan,gellan gum,xanthan gum,curdlan,guar gum,locust bean gum and pectin were also investigated. The results showed that polysaccharide gum solution FJAT-10151-DTJZ was non-Newton fluid. It's viscosity rised with its concentration and reached to343 m Pa·s when the concentration was 1%. The p H change and freezing-thawing played negligible effects on its viscosity. Its viscosity was 808 m Pa·s when it was heated at 75 ℃ for 150 min. Besides,FJAT-10151-DTJZ had no synergistic interaction with chitosan,gellan gum,xanthan gum,curdlan,guar gum,locust bean gum and pectin except konjac gum.国家948项目(2014-Z48);; 福建省公益类科研院所专项(2015R1018-2);; 福建省农业科学院科技创新项目(2015CX-7

Study on Dispensing Technology and Equipment Development for Large LCD Manufacture

液晶显示器（LiquidCrystalDisplay，简称LCD）涂胶工艺（Dispensing）是其在生产过程中的关键工艺流程之一。此工艺的主要目的是在液晶显示器面板裸露的电极线路上涂布胶状物质，大幅提高电极的耐腐蚀性，保护线路不受环境水分和灰尘的影响，提升产品良品率。随着液晶显示技术向大面积、窄边框、无边框、曲面、超高清等技术发展，其对涂胶工艺提出了更高的要求和挑战。本文对涂胶工艺的关键参数进行研究，并开发了一套新型接触式涂胶设备，以期提高大面积涂胶工艺质量。本文的主要内容如下： （1）详细分析了液晶显示器的发展趋势，介绍了液晶显示屏的主要结构，总结了常规涂胶工艺的分类与涂胶方式；通过涂...Liquid crystal display dispensing process is the one of the key process in the production. The main purpose of this process is that the LCD panel coated colloidal substances on the bare electrode lines, to improve the corrosion resistance of the electrode greatly and it Protect the circuit from the environment of water and dust to improve product reliability. Liquid crystal display technology of d...学位：工程硕士院系专业：航空航天学院_工程硕士(机械工程)学号：X201018201

UVA Assisted 4-Thiothymidine for Cancer Treatment

This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized. As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine, thus 4-thiothymidine can be readily incorporated into cellular DNA, and with the help of thymidine kinase, much more preferably into cancerous DNA. Unlike thymidine, 4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light. Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment. Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed. The various interactions between 4-thiothymidine with human serum albumin are introduced. Finally, a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given

The Role and Mechaninsm study of IL-20-related Cytokines contribute to Autoimmune Myocarditis in Mice

目的：免疫相关因素与心肌炎引起的心肌纤维化密切相关。前期研究表明，IL-10家族成员在心肌炎慢性期心肌纤维化的形成过程中发挥重要作用。IL-20是最新发现的IL-10家族成员之一，具有调节细胞增殖和分化的作用。但IL-20是否参与心肌炎心肌纤维化过程尚不清楚。本课题通过实验探讨IL-20及其相关因子对小鼠自身免疫性心肌炎（EAM）心肌纤维化的影响及可能的分子调节机制。 方法：利用小鼠心肌肌球蛋白多肽MyHC6l4-629和完全弗氏佐剂充分混合后，于第0天和第7天皮下注射建立小鼠EAM模型；组织切片H&E染色及Masson染色评估心肌组织炎症及纤维化程度；RealtimePCR及Western...Aims: Immune-related cytokines are closely associated with myocardial fibrosis induced by myocarditis. Previous studies had shown IL-10 family members play an important role in the formation of myocardial fibrosis in chronic myocarditis. IL-20 is one of the latest findings of the IL-10 family members which play a role in regulating the proliferation and differentiation of cells. However, it is unc...学位：医学硕士院系专业：医学院_内科学学号：2452012115314

Technology development in nano-sized photocatalyst powder preparation technologies

Nano-sized semiconductor powders for use as photocatalysts have great potential in environmental and energy engineering applications. The photocatalytic activity of photocatalyst is significantly affected by preparation process since the crystalline structure of photocatalyst is dependent on preparation conditions. This paper aims to give an overview of the research progress of nano-sized photocatalyst powder preparation technologies, including solid route, gas phase route, and liquid route. The advantages and disadvantages of different preparation technologies are analyzed and compared. The research direction and prospect of photocatalyst preparation method is analyzed.纳米半导体材料作为光催化剂在环境、能源领域具有广阔的应用前景。光催化剂的制备过程对催化剂的晶体结构有重要的影响,从而影响其光催化活性。本文较系统地综述了国内外对光催化剂纳米粉体制备的研究进展,包括固相法、气相法和湿化学法。对比分析了各种制备技术的优缺点,并对今后的研究方向和应用前景进行了分析。link_to_subscribed_fulltextpublished_or_final_versio

The role of LRP1 in microglia and neuroinflammation

神经炎症以中枢神经系统中小胶质细胞的激活、炎症因子以及趋化因子的大量表达为特征。小胶质细胞作为脑内最主要的免疫和吞噬细胞，在神经损伤以及包括阿尔兹海默症（Alzheimer’sdisease，AD）在内的神经退行性疾病中过度激活，同时起到神经保护或者毒性损伤功能。作为载脂蛋白E（apolipoproteinE，apoE）和β淀粉样蛋白（amyloid-β，Aβ）最主要的受体，低密度脂蛋白受体相关蛋白1（low-densitylipoproteinreceptor-relatedprotein1，LRP1）大量表达在脑内介导Aβ的清除，在AD的病理进程中发挥着重要作用。此外，LRP1可以调节外周...Neuroinflammation is characterized by microglial activation and the increased levels of cytokines and chemokines in the central nervous system (CNS). Microglia, the resident immune and phagocytic cells of the brain, plays both beneficial and toxic roles when over-activated upon nerve injury or in neurodegenerative diseases, including Alzheimer’s disease (AD). The low-density lipoprotein receptor-r...学位：理学博士院系专业：医学院_生理学学号：2452012015397

Study on Self-assembly Behavior and Multiple-stimuli-responsive Property of Azobenzene-based Amphiphilic Copolymers in Solution

环境响应聚合物分子链中含有特殊的响应基团，能够对外界环境的改变做出结构和性质的调整。许多科研团队致力于设计这类聚合物，并以此来丰富其在药物传送与释放方面的应用。偶氮苯由于有独特的光响应性和还原响应性，将其嵌入到聚合物中，通过光照或加入还原性物质便可调控其自组装聚集体的结构与实现药物分子的释放等，使其成为自组装领域的研究热点。本文先合成活性的偶氮苯单体，再将其与其他响应性单体通过RAFT法进行共聚，制备出含偶氮苯基团的多重刺激响应双亲共聚物，研究了共聚物的自组装行为、胶束的荧光及控制释放性能。以下是本文的主要内容： 1.借助重氮化反应与偶合反应，制得羟基偶氮苯HOAZO。将其与酰氯反应，转变为...Stimuli-responsive polymeric systems integrating with special responsive moieties can undergo alteration of their chemical structures and physical properties in response to external stimulus. A great deal of work has been done to design multi-stimuli-responsive polymeric systems to enrich applications in the fields of drug controlled release. Azobenzene, as a special light and reduction dual-stimu...学位：工程硕士院系专业：材料学院_工程硕士(材料工程)学号：2072013115009