双膦酸盐类药物用于肿瘤辅助治疗的临床研究进展

双膦酸盐是用于骨骼疾病及钙代谢性疾病治疗的一类药物,主要用于治疗骨质疏松症、佩吉特病、高钙血症等。同时临床研究显示双膦酸盐还可用于多发性骨髓瘤、乳腺癌、肾癌、前列腺癌等疾病的辅助治疗,改善患者的临床结局,尤其是唑来膦酸盐的抗肿瘤效果更具优势,被广泛应用于多种恶性肿瘤的临床研究。本文就双膦酸盐在肿瘤辅助治疗中的临床研究进展进行综述。国家自然科学基金面上项目(31670939

危重症伴胃潴留患者肠内营养支持的药学监护

目的探讨临床药师在危重症患者营养支持中的作用。方法临床药师参与1例在实施肠内营养支持过程中出现胃潴留的危重症患者的治疗,建议医师根据病情变化及时调整营养支持方案。结果临床药师为患者提供个体化药学服务,提高了临床治疗效果,改善胃潴留的情况。结论临床药师在为患者提供个体化营养支持方面具有自身的优势,能在临床治疗中发挥重要作用。中华医学会课题(2016B-YX025);;重庆市高等教育教学改革研究项目(163198);;院所教育科学研究项目(50212-2434、2636

柴胡注射液的临床应用研究概况

通过中国医院知识仓库(简称CHkd)期刊全文数据库检索有关柴胡注射液的临床研究有关文献,对中药柴胡注射液的临床研究作一归纳,以期对临床用药提供参考

男性更年期综合征中医药研究述评

对中医药治疗男性更年期综合征从基础和临床研究进行了回顾和分析。表明中医药治疗本病具有良好的临床疗效和优势;指出当前研究尚存在的问题;提出今后研究的重点

An Investigation of Factors Influencing Clinical Decision-making Skills of Nurses

临床决策是护理临床实践过程中的重要组成部分。作为护士所应具备的一种 基本能力，提高临床决策能力能够帮助护士提高照护质量，并影响护理干预结果。 了解临床决策能力的影响因素，能够为有效提高护士的临床决策能力水平提供依 据。因此，有必要深入探讨影响护士临床决策能力的因素。 目的：（1）描述护士的临床决策能力情况；（2）探讨护士临床决策能力的影响因 素。 方法：采取便利抽样，抽取厦门大学附属中山医院和厦门大学附属第一医院的临 床护士共216名。采用问卷调查法，由护士填写一般资料调查表、护士实践决策 能力测评量表、护士工作压力源量表、工作效能条件量表。 结果：（1）临床决策能力的测量包...Clinical decision-making (CDM) is one of the most necessary parts of professional nursing practice. CDM skills as a generic competence can help to enhance the quality of nursing care and influence patients’ outcomes. Hence, knowing the influential factors can help to improve the current level of nurses’ CDM skills. Therefore, it is necessary to explore the factors influencing nurses’ clinical dec...学位：医学硕士院系专业：医学院_护理学学号：2452012115311

Evaluation of medication treatment for Alzheimer's disease on clinical evidence

<p><strong>Objective</strong> To formulate the best treatment plan for Alzheimer's disease patients by evaluating the therapeutic efficacy and side effect of various evidence-based programs. <strong>Methods</strong> Alzheimer's disease, donepezil, rivastigmine, galantamine, memantine, rosiglitazone, etc. were defined as retrieval words. PubMed, Cochrane Library, Wanfang Data and China National Knowledge Infrastructure (CNKI) databases were used with applying of manual searching. Systematic reviews, randomized controlled trials (RCT), controlled clinical trials and case-observation studies were collected and evaluated by Jadad Scale. <strong>Results</strong> After screening, 33 selected resources included 14 systematic reviews, 14 randomized controlled trials, 4 controlled clinical trials and 1 case-observation study. According to Jadad Scale, total 28 articles were evaluated to be high quality (12 with score 4, 10 score 5, 6 score 7), and 5 were low quality with score 3. It was summarized as follows: 1) Alzheimer's disease is a progressive neurodegenerative disease for which no cure exists. To date, only symptomatic treatments with cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and an N-methyl-D-aspartate (NMDA) receptor noncompetitive antagonist (memantine), are effective and well tolerated to counterbalance the neurotransmitter disturbance, but cannot limit or impact on disease progression. 2) Disease modifying drug is an potential agent, with persistent effect on slowing the progression of structural damage, and can be detected even after withdrawing the treatment. Many types of disease modifying drugs are undergoing clinical trials. <strong>Conclusions</strong> Using evidence-based medicine methods can provide best clinical evidence on Alzheimer's disease treatment.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.03.009</p

A Prospective Randomized Study of Adjuvant Chemotherapy in Resected Stage IIIA-N2 Non-small Cell Lung Cancer

Background and objective Lung cancer is one of the leading cause of cancer-related death around the world. Surgery is the primary treatment for patients with stage I, II, or IIIA non-small cell lung cancer (NSCLC). However, longterm survival of NSCLC patients after surgery alone is largely unsatisfactory. We undertook to determine whether adjuvant vinorelbine/paclitaxel plus carboplatin prolong overall survival among patients with completely resected stage IIIA-N2 nonsmall cell lung cancer. Methods We randomly assigned patients with completely resected stage IIIA-N2 non-small cell lung cancer to vinorelbine/paclitaxel plus carboplatin or to observation. Results A total of 150 patients (1999-2003) underwent randomization to vinorelbine/paclitaxel plus carboplatin (79 patients) or observation. In both groups, the median age was 57 years, 73 percent were male, and 28 percents had squamous carcinoma. Chemotherapy caused neutropenia in 82 percents of patients (including grade 3 and 4 neutropenia in 42 percent) and there was no treatment-related death observed in this trial. After median follow-up of 39 months (range 1-110), overall survival was significantly prolonged in the chemotherapy group as compared with the observation group (33 months versus 24 months, χ2=4.363, P=0.037), as was disease-free survival (32 months versus 20 months, χ2=5.413, P=0.020). Five-year overall survival rates were 31.1 percent and 19.1 percent, respectively. Conclusion Adjuvant vinorelbine/paclitaxel plus carboplatin have an acceptable level of toxicity and prolongs disease-free and overall survival among patients with completely resected stage IIIA-N2 non-small cell lung cancer

Design and Implementation of Clinical Pathway Information System Based on Caché

临床路径是医院重要工作的一部分。国家卫生行政部门已经于2009年正式 提出该项工作，主要是完成某一单病种的诊断、治疗、康复和护理所制定的一个 诊疗标准化模式。临床路径实施初期阶段，医院使用手工方法进行管理，无法固 定单个病种治疗过程，且经常调整治疗方案，根本无法达到卫生行政部门的要求， 与实行临床路径的初衷相违背。为了规范临床路径管理工作，构建一套临床路径 信息管理系统显得尤为迫切和重要。 本文讨论了临床路径信息系统的概念与背景，分析了临床路径的业务流程， 并简述了该系统与其它业务系统的关联。需求分析完成后，又完成了该系统的架 构、功能要求及Caché数据库的设计工作。根据需求...Clinical pathway is an important part of the hospital daily routine. The State Health Department has formally proposed this work in 2009,with focus on establishment of a standardized model on clinical diagnosis, treatment, rehabilitation and care. During the early stage of the implementation, manual methods are applied, which cause big variation of the treatment of a single disease. Moreover, ...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201323012

Clinical Research on “Gui” Acupuncture Method for Chronic Non-specific Low Back Pain

目的：比较“龟刺”与常规针刺方法治疗慢性非特异性腰痛的疗效差异，为临床上治疗本病提供新的治疗思路和方法。 方法：本研究采用随机分组单盲对照法对所选病例进行前瞻性研究，受试者来源于厦门大学附属中山医院演武分院六楼针灸科门诊，收集符合纳入标准的60例慢性非特异性腰痛患者，随机分为治疗组与对照组，每组30例。治疗组按照周然宓教授所创“龟刺”法的选穴与操作标准，对照组按照石学敏主编《针灸学》中治疗腰痛的选穴与操作标准分别进行治疗。两组均以治疗10次为一个疗程，隔两天治疗1次，每周治疗2次，共治疗1个疗程，为期5周。采用视觉模拟评分法（VAS）以及Oswestry功能障碍指数（ODI）对患者治疗前后的...Objective: To compare the difference between the “Gui” acupuncture method and routine acupuncture method in the clinical efficacy on chronic nonspecific low back pain. In order to carrying forward Professor Zhou’s academic thoughts and provide a way of thinking for the clinical treatment of this disease. Methods: A prospective study of the selected cases were performed by using a randomized, sing...学位：医学硕士院系专业：医学院_针灸推拿学学号：2452013115355

Efficacy observation of danshen injection iontophoresis treatment for vitreous hemorrhage

AIM: To probe into the clinical value of danshen injection iontophoresis in treatment of vitreous hemorrhage. <p>METHODS: Eighty-eight vitreous hemorrhage patients(88 eyes)were selected from June 2012 to June 2013 in our hospital. The patients were divided into observation group and control group randomly, with 44 cases(44 eyes)in each group. The patients in control group were treated with xueshuantong clinical drug treatment. The patients in observation group were treated with danshen injection iontophoresis clinical drug treatment. The clinical treatment and visual recovery situations of the patients in two groups were compared and analyzed. <p>RESULTS: The cure rate and total effective rate of observation group were 75% and 95%. The cure rate and total effective rate of control group were 59% and 77%. There were statistically significant differences(<i>P</i><0.05). Compared with control group, the rate of patients in observation group with visual acuity between 0.6 to 0.9 was improved significantly, rate of visual acuity less 0.2 was reduced significantly, and the whole blood viscosity, plasma viscosity, hematocrit and fibrinogen were improved significantly, there were statistical significance(<i>P</i><0.05).<p>CONCLUSION: Danshen injection iontophoresis therapy has positive role in improving clinical outcomes and promoting visual function for patients with vitreous hemorrhage