Medicaid spending burden among beneficiaries with treatment-resistant depression.

AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with major depressive disorder (MDD) beneficiaries without TRD (non-TRD-MDD) and randomly selected patients without MDD (non-MDD). Differences in HRU and per-patient-per-year costs were reported in incidence rate ratios (IRRs) and cost differences (CDs), respectively. RESULTS: TRD beneficiaries had higher HRU than 1:1 matched non-TRD-MDD (e.g., inpatient visits: IRR = 1.41) and non-MDD beneficiaries (N = 14,710 per cohort; e.g., inpatient visits: IRR = 3.42, p \u3c 0.01). TRD beneficiaries incurred greater costs versus non-TRD-MDD (CD = US$4382) and non-MDD beneficiaries (CD = US$8294; p \u3c 0.05). CONCLUSION: TRD is associated with higher HRU and costs versus non-TRD-MDD and non-MDD. TRD poses a significant burden to Medicaid

Development of a trench cutting re-mixing deep wall method model test device

The trench cutting re-mixing deep wall (TRD) is a new type of underground waterproof curtain. Mixing uniformity is the key index affecting the efficiency and quality of this method. However, because of many influencing factors, existing theories cannot be used to express the relationship between various factors and mixing uniformity. By analyzing the cutting and mixing process of the TRD method, the main factors affecting the uniformity of the mixing were obtained. A model test device was designed and manufactured, based on Buckingham's pi theorem. The validity of the model test device was verified through a comparative analysis of model and field test results. The model test device was demonstrated to be able to simulate the mixing process of the TRD method. The results provide guidance for promotion and better application of the TRD method

Characterization and suppression techniques for degree of radiation damping in inversion recovery measurements

Radiation damping (RD) has been shown to affect T1 measurement in inversion recovery experiments. In this work, we demonstrate that the extent of RD depends upon the T1 of the sample. RD difference spectroscopy (RADDSY) is used to characterize the severity of RD, while gradient inversion recovery (GIR) is used for RD suppression in T1 measurements. At 9.4 T, for the radiation damping characteristic time (Trd) of 50 ms, these investigations show non-negligible RD effects for T1 values greater than Trd, with severe distortions for T1 longer than about 150 ms, showing reasonable agreement with the predicted Trd. We also report a discrepancy between published expressions for the characteristic RD time

The Transition Radiation Detector for ALICE at LHC

The Transition Radiation Detector (TRD) for the ALICE experiment at the Large Hadron Collider (LHC) identifies electrons in p+p and in the challenging high multiplicity environment of heavy-ion collisions and provides fast online tracking for the ALICE Level1 trigger. The TRD is designed to have excellent position resolution and pion rejection capability. Presently, six of the 18 TRD supermodules are installed in the ALICE central barrel. In 2008, four supermodules were installed and commissioning of the detector using cosmic ray tracks was successfully performed. We briefly describe the design of the detector and report on the performance and current understanding of the detector based on these data.Comment: 4 pages, 6 figures - To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse

Physics with the ALICE Transition Radiation Detector

The ALICE Transition Radiation Detector (TRD) significantly enlarges the scope of physics observables studied in ALICE, because it allows due to its electron identification capability to measure open heavy-flavour production and quarkonium states, which are essential probes to characterize the Quark-Gluon-Plasma created in nucleus-nucleus collisions at LHC. In addition the TRD enables to enhance rare probes due to its trigger contributions. We report on the first results of the electron identification capability of the ALICE Transition Radiation Detector (TRD) in pp collisions at $\sqrt{s}$ = 7 TeV using a one-dimensional likelihood method on integrated charge measured in each TRD chamber. The analysis of heavy flavour production in pp collisions at $\sqrt{s}$ = 7 TeV with this particle identification method, which extends the $p_{t}$ range of the existing measurement from $p_{t}$ = 4 GeV/c to 10 GeV/c and reduces the systematic uncertainty due to particle identification, is presented. The performance of the application of the TRD electron identification in the context of J/\psi measurements in Pb-Pb collisions is also shown.Comment: 6 pages; 9 figures; conference proceedings: TRDs for the third Millennium 4th Workshop on Advanced Transition Radiation Detectors for Accelerator and Space Application

Triggering with the ALICE TRD

We discuss how a level-1 trigger, about 8 us after a hadron-hadron collision, can be derived from the Transition Radiation Detector (TRD) in A Large Ion Collider Experiment (ALICE) at the LHC. Chamber-wise track segments from fast on-detector reconstruction are read out with position, angle and electron likelihood. In the Global Tracking Unit up to 6 tracklets from a particle traversing the detector layers are matched and used for the reconstruction of transverse momentum and electron identification. Such tracks form the basis for versatile and flexible trigger conditions, e.g. single high-pt hadron, single high-pt electron, di-electron (J/Psi, Upsilon) and at least n close high-pt tracks (jet). The need for low-latency on-line reconstruction poses challenges on the detector operation. The calibration for gain (pad-by-pad) and drift velocity must be applied already in the front-end electronics. Due to changes in pressure and gas composition an on-line monitoring and feedback loop for these parameters is required. First experiences on the performance were gathered from triggering in cosmic and pp runs.Comment: 6 pages, 10 figure

A Monte Carlo code for full simulation of a transition radiation detector

A full simulation of a transition radiation detector (TRD) based on the GEANT, GARFIELD, MAGBOLTZ and HEED codes has been developed. This simulation can be used to study and develop TRD for high energy particle identification using either the cluster counting or the total charge measurement method. In this article it will be also shown an application of this simulation to the discrimination of electrons from hadrons in beams of momentum of few GeV/c or less, assuming typical TRD configuration, namely radiator-detector modules.Comment: 14 pages with 12 figure

Evaluation of a new trauma-related drinking to cope measure: Latent structure and heritability

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur, share latent genetic risk, and are associated with many negative public health outcomes. Via a self-medication framework, trauma-related drinking to cope (TRD), an unexplored phenotype to date, may help explain why these two disorders co-occur, thus serving as an essential target for treatment and prevention efforts. This study sought to create a novel measure of TRD and to investigate its indirect influences on the association between PTSD and AUD, as well as its potential shared molecular genetic risk with PTSD in a genetically-informative study of college students. A sample of 1,896 undergraduate students with a history of trauma and alcohol use provided genotypic data and completed an online assessment battery. The psychometric properties of TRD and how it relates to relevant constructs were examined using descriptive statistics and structural equation modeling. Results of a correlated multiple mediator model indicated that, while accounting for the effects of generalized drinking motives, TRD partially mediated the relation between PTSD and alcohol use problems (β = 0.213, p \u3c .001), consistent with the self-medication hypothesis, and that this relationship was stronger for males (β = 0.804, p \u3c .001) than for females (β = 0.463, p \u3c .001). Results were substantiated using longitudinal data. Genotypic analyses to be presented will include univariate genome wide complex trait analyses (GCTA) to establish SNP-based heritability associated with TRD and PTSD, separately, as well as bivariate GCTA to examine potential overlap in heritability between TRD and PTSD.https://scholarscompass.vcu.edu/gradposters/1047/thumbnail.jp

Performance of the AMS-02 Transition Radiation Detector

For cosmic particle spectroscopy on the International Space Station the AMS experiment will be equipped with a Transition Radiation Detector (TRD) to improve particle identification. The TRD has 20 layers of fleece radiator with Xe/CO2 proportional mode straw tube chambers. They are supported in a conically shaped octagon structure made of CFC-Al-honeycomb. For low power consumption VA analog multiplexers are used as front-end readout. A 20 layer prototype built from final design components has achieved proton rejections from 100 to 2000 at 90% electron efficiency for proton beam energies up to 250 GeV with cluster counting, likelihood and neural net selection algorithms.Comment: 11 pages, 25 figures, espcrc2.sty (elsevier 2-column