Nowcasting Thunderstorms for Munich Airport

The successful demonstration and assessment of the DLR thunderstorm nowcasting algorithms at Munich Airport during two campaigns in the summers of 2010 and 2011 are described. The algorithms Cb-TRAM and Rad-TRAM, that detect, monitor, and forecast up to one hour (nowcast) thunderstorm cells from satellite and radar data, run in real time and provided new thunderstorm products for users at the airport. The products were presented on displays the users were already familiar with as well as on webpages designed by DLR. On the webpages, also additional information like measurements with DLR’s polarimetric radar and model forecasts was shown. Moreover, thunderstorm warnings were is-sued and sent via email to the users whenever a thunderstorm was detected in the terminal manoeu-vring area of the airport of Munich. The nowcasting skills of Rad-TRAM and Cb-TRAM are encouraging, especially for lead times up to 30 minutes, and the user feedback on the DLR thunderstorm products was very positive. The Rad-TRAM and Cb-TRAM products provide a good overview on the situation and its future development, and the thunderstorm warnings were very helpful for the collaborative decision making at the airport. However, some suggestions for improvements were made like the demand for nowcasts beyond one hour. This will be considered within the integrated weather forecast system, WxFUSION, which has been further developed during the campaigns

Sex Trafficking and the Attribution of Blame: A Comparison between Vietnamese and American Perception of Sex-trafficked Individuals

Sex trafficking is one of the most persistent issues in Asian countries and specifically in Vietnam. Hundreds of Vietnamese are trafficked daily across the world, but mainly in Taiwan, Malaysia, South Korea, Laos, China, and Thailand. Sexually trafficked individuals are reported to have symptoms of depression, post-traumatic stress disorder, suicidal tendencies, and physical violence. Despite the increasing number of victims, there is a lack of empirical research on issues relating to the impact of human trafficking on Vietnamese people and especially the public attitude about the problem. The current study examined the public’s general knowledge of trafficking myths, their willingness to believe in the trafficking situation, and their tendency to place blame on the victim, in relation to the sex of the participants and the sex of the victims. Vietnamese citizens across the country (N= 922) responded to a vignette portraying a sex trafficking situation and completed the Human Trafficking Myth survey. Results indicated that the sex of the participants and the sex of the victims significantly correlated with the participants’ perception of the human trafficking myths, trafficking story and victim’s responsibility. Acknowledging the paucity of cross-culture empirical research, the current study also compared the Vietnamese sample with the American sample that completed similar scales. The results of study 1 and 2 have the potential to serve the needs of anti-trafficking campaigns in Vietnam and support the collaboration of different countries in their effort of combating human trafficking

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment

Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent that blocks tumor cell proliferation. Currently, there are no therapies aimed at reducing tumor cell invasion. Ion channels are candidate molecular targets involved in glioma cell migration and infiltration into the brain parenchyma. In this paper we demonstrate that: i) blockade of the calcium-activated potassium channel KCa3.1 with TRAM-34 has co-adjuvant effects with TMZ, reducing GL261 glioma cell migration, invasion and colony forming activity, increasing apoptosis, and forcing cells to pass the G2/M cell cycle phase, likely through cdc2 de-phosphorylation; ii) KCa3.1 silencing potentiates the inhibitory effect of TMZ on glioma cell viability; iii) the combination of TMZ/TRAM-34 attenuates the toxic effects of glioma conditioned medium on neuronal cultures, through a microglia dependent mechanism since the effect is abolished by clodronate-induced microglia killing; iv) TMZ/TRAM-34 co-treatment increases the number of apoptotic tumor cells, and the mean survival time in a syngeneic mouse glioma model (C57BL6 mice implanted with GL261 cells); v) TMZ/TRAM-34 co-treatment reduces cell viability of GBM cells and cancer stem cells (CSC) freshly isolated from patients.Taken together, these data suggest a new therapeutic approach for malignant glioma, targeting both glioma cell proliferating and migration, and demonstrate that TMZ/TRAM-34 co-treatment affects both glioma cells and infiltrating microglia, resulting in an overall reduction of tumor cell progression

Optimal polarisation equations in FLRW universes

This paper presents the linearised Boltzmann equation for photons for scalar, vector and tensor perturbations in flat, open and closed FLRW cosmologies. We show that E- and B-mode polarisation for all types can be computed using only a single hierarchy. This was previously shown explicitly for tensor modes in flat cosmologies but not for vectors, and not for non-flat cosmologies.Comment: 27 pages, prepared for submission to JCAP. Matches published versio

Book review: The Tram Conductor’s Blue Cap

This article reviews the book “The Tram Conductor’s Blue Cap”, by Michael Harlow

A systematic review comparing the functional changes and complications of DIEP and TRAM flaps in patients receiving breast reconstruction

Aim: Treatment for breast cancer may involve unilateral or bilateral mastectomy, with subsequent breast reconstruction surgery. Using autologous tissue flaps during reconstructive surgery is increasingly popular. The aim of this systematic review was to determine if the DIEP flap is more effective than the TRAM flap for breast reconstruction in females after a mastectomy in terms of donor site morbidity, recipient site morbidity, and functional outcome. Methods: Studies were identified using the databases Medline and Embase and applying predefined search criteria. The limits applied were; peer-reviewed, published between January 1980 to May 2013, human trials, English language. Study inclusion followed a review of the title, abstract, and full text by two independent researchers. Results: Two trends were identified. 1) DIEP flap surgery reduces the risk of abdominal weakness without increasing the risk of flap complications if performed by a surgeon well trained in microsurgery; 2) TRAM flap surgery remains a good alternative due to its evolution towards muscle-sparing techniques. Conclusion: This appears to be the first systematic review in this area of research. The evidence demonstrates that DIEP flap reduces postoperative abdominal morbidity, with no increased flap complication compared to the TRAM flap if performed by a surgeon well trained in microsurgery