Development of fabrication facility for braid composite: structures.

This report gives the progress of work of the AR & DB sponsored project during the period April 1936 to December 1987. Preliminary design of the braiding facility was carried out and a layout of the facility was carried. Specifications of the microcomputer based electronic controller required for the braiding facility were drafted and enquiries were sent for the procurement of an experimental braiding unit, precision slide and the electronic controller of the braiding facility

Structural stability research council: proceedings 1979

One of the purposes of the Council is to maintain a forum where problems related to the design and behavior of columns and other compression elements in metal structures can be presented for evaluation and discussion. The Annual Technical Session provides an opportunity to carry out this function. The 1979 Annual Technical Session was held on April 24 and 25 at The William Penn Hotel in Pittsburgh, Pennsylvania. Eighty-five persons attended the Session and twenty-seven papers were delivered. A panel discussion on Stability of Space Frame Structures was held in the evening of April 24, 1979. The panelists were R. S. Loomis, D. T. Wright, and E. P. Becker. The moderator was J. L. Durkee. In conjunction with the Technical Session, an Annual Business Meeting was held for the purpose of electing new officers and members, and discuss financial and other business matters. Summaries of the technical papers, the panel discussion and minutes of the business meeting are recorded in the following pages. The attendance list is also included

Structural stability research council: proceedings 1980

One of the purposes of the Council is to maintain a forum where structural stability aspects of the behavior of frames, columns and other compression-type elements in metal and compression structures can be presented for evaluation and discussion. The Annual Technical Session provides an opportunity to carry out this function. Summaries of the technical papers, the panel discussion and minutes of the business meeting are recorded in the following pages. The attendance list is also included

Structural stability research council: proceedings 1976

One of the purposes of the Council is to maintain a forum where problems related to the design and behavior of columns and other compression elements in metal structures can be presented for evaluation and discussion. The Annual Technical Session provides an opportunity to carry out this function. The 1976 Annual Technical Session was held on March 2 and 3 at the SheratonBiltmore Hotel in Atlanta, Georgia. Fifty-five persons attended the session and nineteen papers were delivered. A panel discussion on New Ideas on Stability of Multistory Buildings was held in the evening of March 2, 1976. the panelists were D. Ruby, J. Springfield and W. J. LeMessurier. The moderator was J. S. B. Iffland. In conjunction with the Technical Session, an Annual Business Meeting was held for the purpose of electing new members, and to discuss financial and other business matters. Summaries of the technical papers, the panel discussion and minutes of the business meeting are recorded in the following pages. The attendance list is also included

Structural Stability Research Council: Proceedings 1982

One of the purposes of the the of Council is to maintain a forum where the the of Council is to maintain a forum where the structural stability aspects of metal andcomposite metal and concrete structures and and their components can be presented for evaluation, and pertinent structural research problems proposed for investigation. The Annual Technical Session provides an opportunity to carry out this function

Structural variation in generated health reports

We present a natural language generator that produces a range of medical reports on the clinical histories of cancer patients, and discuss the problem of conceptual restatement in generating various textual views of the same conceptual content. We focus on two features of our system: the demand for 'loose paraphrases' between the various reports on a given patient, with a high degree of semantic overlap but some necessary amount of distinctive content; and the requirement for paraphrasing at primarily the discourse level

Structural and molecular characteristics of axons in the long head of the biceps tendon

The innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since pathologies of the LHBT are a major source of shoulder pain. Thus, the study aimed to characterize structurally and molecularly nervous elements of the LHBT. The proximal part of 11 LHBTs was harvested intraoperatively. There were 8 female and 3 male specimens. Age ranged from 66 to 86 years. For structural analyses, nervous elements were viewed in the transmission electron microscope. For molecular characterization, we used general neuronal markers including antibodies against neurofilament and protein gene product 9.5 (PGP9.5) as well as specific neuronal markers including antibodies against myelin basic protein (MBP), calcitonin gene-related product (CGRP), substance P (SP), tyrosine hydroxylase (TH), and growth-associated protein 43 (GAP43). Anti-neurofilament and anti-PGP9.5 visualized the overall innervation. Anti-MBP visualized myelination, anti-CGRP and anti-SP nociceptive fibers, anti-TH sympathetic nerve fibers, and anti-GAP43 nerve fibers during development and regeneration. Immunolabeled sections were analyzed in the confocal laser scanning microscope. We show that the LHBT contains unmyelinated as well as myelinated nerve fibers which group in nerve fascicles and follow blood vessels. Manny myelinated and unmyelinated axons exhibit molecular features of nociceptive nerve fibers. Another subpopulation of unmyelinated axons exhibits molecular characteristics of sympathetic nerve fibers. Unmyelinated sympathetic fibers and unmyelinated nociceptive fibers express proteins that are found during development and regeneration. Present findings support the hypothesis that ingrowth of nociceptive fibers are the source of chronic tendon pain

Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER

Protein import into the endoplasmic reticulum (ER) is the first step in the biogenesis of around 10,000 different soluble and membrane proteins in humans. It involves the co- or post translational targeting of precursor polypeptides to the ER, and their subsequent membrane insertion or translocation. So far, three pathways for the ER targeting of precursor polypeptides and four pathways for the ER targeting of mRNAs have been described. Typically, these pathways deliver their substrates to the Sec61 polypeptide-conducting channel in the ER membrane. Next, the pre cursor polypeptides are inserted into the ER membrane or translocated into the ER lumen, which may involve auxiliary translocation components, such as the TRAP and Sec62/Sec63 complexes, or auxiliary membrane protein insertases, such as EMC and the TMCO1 complex. Recently, the PEX19/PEX3-dependent pathway, which has a well-known function in targeting and inserting vari ous peroxisomal membrane proteins into pre-existent peroxisomal membranes, was also found to act in the targeting and, putatively, insertion of monotopic hairpin proteins into the ER. These either remain in the ER as resident ER membrane proteins, or are pinched off from the ER as components of new lipid droplets. Therefore, the question arose as to whether this pathway may play a more general role in ER protein targeting, i.e., whether it represents a fourth pathway for the ER targeting of precursor polypeptides. Thus, we addressed the client spectrum of the PEX19/PEX3-dependent pathway in both PEX3-depleted HeLa cells and PEX3-deficient Zellweger patient fibroblasts by an established approach which involved the label-free quantitative mass spectrometry of the total proteome of depleted or deficient cells, as well as differential protein abundance analysis. The negatively affected proteins included twelve peroxisomal proteins and two hairpin proteins of the ER, thus confirming two previously identified classes of putative PEX19/PEX3 clients in human cells. Interestingly, fourteen collagen-related proteins with signal peptides or N-terminal transmembrane helices belonging to the secretory pathway were also negatively affected by PEX3 deficiency, which may suggest compromised collagen biogenesis as a hitherto-unknown contributor to organ failures in the respective Zellweger patients