Mediated culture / mediated education

It took tens of thousands of years for writing to emerge after humans spoke their first words. It took thousands more before the printing press and a few hundred again before the telegraph. Today a new medium of communication emerges every time somebody creates a new web application. A Flickr here, a Twitter there, and a new way of relating to others emerges. New types of conversation, argumentation, and collaboration are realized. Using examples from anthropological fieldwork in Papua New Guinea, YouTube, classrooms, and "the future," this presentation will demonstrate the profound yet often unnoticed ways in which media "mediate" our conversations, classrooms, and institutions. We will then apply these insights to an exploration of the implications for how we may need to rethink how we teach, what we teach, and who we think we are teaching

Computer-mediated conferencing

This section addresses issues of Computer-Mediated Conferencing (CMC) as a teaching and learning resource, concentrating upon skills development within that context. The materials are appropriate for different experience levels of learners and provide a range of pathways to the materials and resources as appropriate for any individual learner or learner group

AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease

Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving muscle pathology in PD mice injected intramuscularly with an AAV-TFEB vector. Here we have evaluated the effects of TFEB systemic delivery on muscle pathology and on functional performance, a primary measure of efficacy in a disorder like PD. We treated 1-month-old PD mice with an AAV2.9-MCK-TFEB vector. An animal cohort was analyzed at 3 months for muscle and heart pathology. A second cohort was followed at different timepoints for functional analysis. In muscles from TFEB-treated mice we observed reduced PAS staining and improved ultrastructure, with reduced number and increased translucency of lysosomes, while total glycogen content remained unchanged. We also observed statistically significant improvements in rotarod performance in treated animals compared to AAV2.9-MCK-eGFP-treated mice at 5 and 8 months. Cardiac echography showed significant reduction in left-ventricular diameters. These results show that TFEB overexpression and modulation of autophagy result in improvements of muscle pathology and of functional performance in the PD murine model, with delayed disease progression

Zmiany w komórkach mezofilu liści roślin Lycopersicon esculentum Mill. spowodowane zasoleniem

Five-week-old tomato plants (Lycopersicon esculentum) cv. Perkoz grown in pots containing garden soil in a growth chamber were submitted to 50 or 150 mM NaCl for 1 h, 2 and 5 days. Tomato leaf anatomy generally did not change after short time salinity, except 5-day-treatment with 150 mM NaCl, where changed cell shape (shrunk and deformed) simultaneously with increased volume of intercellular spaces (IS) were observed. Although leaf hydration (H) depleted only 1 h after 150 mM NaCl treatment both salt concentrations generated two coexisting populations of saltaffected mesophyll cells: (i) slightly-affected (Sl-A) which showed incipient plasmolysis or slightly changed shapes, and (ii) severely-affected (Sv-A) which showed severe plasmolysis; serious deformation of cell shape or disorganization including cell degeneration. In Sl-A cells salinity changed location and shape of chloroplasts which were: more rounded, with oversized starch grains (SG) (2d) or more flat (5d). Salt-mediated changes were becoming more distinguished and pronounced with length of 150 mM NaCl treatment. The amount of salt-affected cells was changing during the experiment and depended on the salt concentration. In 50 mM-treated plants salt-affected cells appeared 1 h after treatment (~40%) and raised up to 78% on 2nd day, however the population of Sl-A cells dominated. In 150 mM NaCl-treated plants the percentage of affected cells raised during the experiment from 75% to 99%. Firstly Sl-A cells dominated, but on the 5th day the majority was Sv-A. Salt-affected cells were distributed quite evenly in palisade or spongy mesophyll, except 2 d after treatment with 50 mM NaCl, when their number was higher in the palisade mesophyll. Sv-A cells in the spongy mesophyll were located mostly near the bundle while in the palisade mesophyll more irregularly. Different susceptibility of cells to salt stress might be the consequence of an unequal distribution of osmotic stress and subsequent ionic stress or physiological state of cells

Mediated Homogenization

Homogenization protocols model the quantum mechanical evolution of a system to a fixed state independently from its initial configuration by repeatedly coupling it with a collection of identical ancillas. Here we analyze these protocols within the formalism of "relaxing" channels providing an easy to check sufficient condition for homogenization. In this context we describe mediated homogenization schemes where a network of connected qudits relaxes to a fixed state by only partially interacting with a bath. We also study configurations which allow us to introduce entanglement among the elements of the network. Finally we analyze the effect of having competitive configurations with two different baths and we prove the convergence to dynamical equilibrium for Heisenberg chains.Comment: 6 pages, 6 figure

Mechanisms of Supersymmetry Breaking in the MSSM

Preliminary Remarks. Gauge mediated supersymmetry breaking. Gravity mediated supersymmetry breaking. Anomaly mediated supersymmetry breaking. Gaugino mediated supersymmetry breaking. Braneworld supersymmetry breaking. Conclusions.Comment: New references added, minor misprints corrected, text otherwise unchange

DNA-Mediated Electrochemistry

The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with lesions, single base mismatches, and protein binding. We have exploited this sensitivity for the development of reliable electrochemical assays based on DNA charge transport at self-assembled DNA monolayers. Here, we discuss the characteristic features, applications, and advantages of DNA-mediated electrochemistry

A Comparison Of Adult- And Peer-Mediated Intervention For Autism: A Case Study

This study examined the response of a young child with autism to two play-based intervention conditions: adult-mediated and peer-mediated. The client was five years old, demonstrated moderate-to-severe autism, and exhibited developmental functioning between the 14 to 34 month level. The peer-mediated condition, based on a modified Integrated Play Group approach, utilized a typically developing peer who was three years of age. The study utilized an ABAB alternating treatment design to compare the impact of the adult- and peer-mediated interventions. Results from the current study suggest that the adult-mediated intervention resulted in increased engagement and more sophisticated social-communicative behaviors than the peer-mediated approach for the child with autism. Clinical implications, limitations, and future research directions are discussed

Strain-gradient mediated local conduction in strained bismuth ferrite films

It has been recently shown that the strain gradient is able to separate the light-excited electron-hole pairs in semiconductors, but how it affects the photoelectric properties of the photo-active materials remains an open question. Here, we demonstrate the critical role of the strain gradient in mediating local photoelectric properties in the strained BiFeO3 thin films by systematically characterizing the local conduction with nanometre lateral resolution in both dark and illuminated conditions. Due to the giant strain gradient manifested at the morphotropic phase boundaries, the associated flexo-photovoltaic effect induces on one side an enhanced photoconduction in the R-phase, and on the other side a negative photoconductivity in the morphotropic [Formula: see text]-phase. This work offers insight and implication of the strain gradient on the electronic properties in both optoelectronic and photovoltaic devices