Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man

Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine catabolites and whether (ii) formation of purines in response to vascular clamping (Pringle maneuver) can be attenuated by prior IPC. Methods: 75 patients were randomly assigned to three groups: group I underwent hepatectomy without vascular clamping; group II was subjected to the Pringle maneuver during resection, and group III was preconditioned (10 min ischemia and 10 min reperfusion) prior to the Pringle maneuver for resection. Central, portal venous and arterial plasma concentrations of adenosine, inosine, hypoxanthine and xanthine were determined by high-performance liquid chromatography. Results: Duration of the Pringle maneuver did not differ between patients with or without IPC. Surgery without vascular clamping had only a minor effect on plasma purine transiently increased. After the Pringle maneuver alone, purine plasma concentrations were most increased. This strong rise in plasma purines caused by the Pringle maneuver, however, was significantly attenuated by IPC. When portal venous minus arterial concentration difference was calculated for inosine or hypoxanthine, the respective differences became positive in patients subjected to the Pringle maneuver and were completely prevented by preconditioning. Conclusion: These data demonstrate that (i) IPC increases formation of adenosine, and that (ii) the unwanted degradation of adenine nucleotides to purines caused by the Pringle maneuver can be attenuated by IPC. Because IPC also induces a decrease of portal venous minus arterial purine plasma concentration differences, IPC might possibly decrease disturbances in the energy metabolism in the intestine as well. Copyright (C) 2005 S. Karger AG, Basel

Rendezvous targeting for space missions

A brief outline of a targeting program for use in the space shuttle mission is presented. This general purpose program can accept a large variety of constraints and can be applied to each maneuver sequence contained in the rendezvous sequence. It consists of a main program which automatically and sequentially calls a general maneuver subroutine to compute each maneuver segment contained in the maneuver sequence

GOES-I/M ascent maneuvers from transfer orbit to station

The Geostationary Operational Environmental Satellite (GOES)-I/M station acquisition sequence consists nominally of three in-plane/out-of-plane maneuvers at apogee on the line of relative nodes and a small in-plane maneuver at perigee. Existing software to determine maneuver attitude, ignition time, and burn duration required modification to optimize the out-of-plane parts and admit the noninertial, three-axis stabilized attitude. The Modified Multiple Impulse Station Acquisition Maneuver Planning Program (SENARIO2) was developed from its predecessor, SCENARIO, to optimize the out-of-plane components of the impulsive delta-V vectors. Additional new features include commputation of short term J sub 2 perturbations and output of all premaneuver and postmaneuver orbit elements, coarse maneuver attitudes, propellant usage, spacecraft antenna aspect angles, and ground station coverage. The output data are intended to be used in the launch window computation and by the maneuver targeting computation (General Maneuver (GMAN) Program) software. The maneuver targeting computation in GMAN was modified to admit the GOES-I/M maneuver attitude. Appropriate combinations of ignition time, burn duration, and attitude enable any reasonable target orbit to be achieved

ASCA Slew Survey

We are systematically analyzing ASCA GIS data taken during the satellite attitude maneuver operation. Our motivation is to search for serendipitous hard X-ray sources and make the ASCA Slew Survey catalog. During its operational life from 1993 February to 2000 July, ASCA carried out more than 2,500 maneuver operations, and total exposure time during the maneuver was ~415 ksec after data screening. Preliminary results are briefly reported.Comment: Proceedings for "X-ray surveys in the light of new observations", Santander (Spain), 2002 September. 1 pag

Development of a flight test maneuver autopilot for an F-15 aircraft

An autopilot can be used to provide precise control to meet the demanding requirements of flight research maneuvers with high-performance aircraft. This paper presents the development of control laws for a flight test maneuver autopilot for an F-15 aircraft. A linear quadratic regulator approach is used to develop the control laws within the context of flight test maneuver requirements by treating the maneuver as a finite time tracking problem with regulation of state rates. Results are presented to show the effectiveness of the controller in insuring acceptable aircraft performance during a maneuver

Analytical investigation of the dynamics of tethered constellations in Earth orbit, phase 2

This Quarterly Report deals with the deployment maneuver of a single-axis, vertical constellation with three masses. A new, easy to handle, computer code that simulates the two-dimensional dynamics of the constellation has been implemented. This computer code is used for designing control laws for the deployment maneuver that minimizes the acceleration level of the low-g platform during the maneuver

Midcourse maneuver operations program

Midcourse Maneuver Operations Program /MMOP/ computes the required velocity change to correct a spacecraft trajectory. The program establishes the existence of maneuvers which satisfy spacecraft constraints, explores alternate trajectories in the event that some out-of-tolerance condition forces a change in plans, and codes the maneuvers into commands

Guidance and maneuver analyzer Patent

Guidance analyzer having suspended spacecraft simulating sphere for astronavigatio